Sentences with phrase «of skeletal diseases»

New knowledge gained from these studies is prerequisite to uncovering the causes of skeletal diseases and to propose new treatment strategies.

Research must thus be pursued to find novel strategies to prevent and treat effectively all types of skeletal diseases.

Maximizing the growth rate in young, growing puppies does not correlate to maximal adult size; however, it does increase the risk of skeletal disease.

Another major factor in the development of skeletal disease in young growing dogs is too much calcium intake.

Too much calcium and phosphorous shows higher rates of skeletal disease.

It has also been shown that excessive dietary calcium in large breed puppies is linked to the increase of skeletal disease In light of this, we follow the recommended criteria of: LOW CALORIES, LIMITED CALCIUM and LOW FATS.

Not exact matches

You face a higher risk of muscular skeletal disorders, obesity, diabetes, cancer, heart disease and more, even if you work out regularly.

Post-race, the blood of a marathoner can paint a picture of diseased organs and biochemical decay thanks to compounds tossed off by the skeletal muscle, heart, and liver, such as troponin, a cardiac enzyme whose elevation signals trauma to the heart.

His bill would limit its application to epilepsy, intractable skeletal muscular spasticity, traumatic brain injury, glaucoma, cachexia, wasting syndrome, Dravet syndrome, HIV / AIDS, Cancer, ALS, multiple sclerosis, muscular dystrophy, Crohn's disease, and terminal illnesses if a patient has a prognosis of less than 12 months to live.

Patients with early - stage and advanced OA, RA or other inflammatory joint disease were recruited for the study alongside a control group of those with good skeletal health, with plasma and synovial fluid samples from both groups being analysed using mass spectrometry.

Muscular dystrophies are a group of more than 30 genetic diseases characterized by progressive weakness and degeneration of the skeletal muscles that control movement.

Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.

The so - called Columbian theory of syphilis's spread was based on finding skeletal remains bearing the signature of the disease — thickened leg and arm bones and skull scars — in a suggestive pattern.

Researchers who previously showed that a gene therapy treatment could save the lives of dogs with a deadly disease called myotubular myopathy — a type of muscular dystrophy that affects the skeletal muscles — have found that the therapy is long - lasting.

The most severe form of the disease is fatal, and even the milder form can cause mild retardation and skeletal problems.

Mutation around the region of the human SOX9 gene, which encodes the Sox9 protein, causes campomelic dysplasia, a congenital disease that is accompanied by skeletal abnormalities and other conditions.

In that disease, fibrodysplasia ossificans progressiva (FOP), a mutation triggers bone growth in muscles, alters skeletal bone formation, and limits motion, breathing, and swallowing, among a host of progressive symptoms.

Sarcopenia is a disease associated with the aging process, resulting in loss of skeletal muscle mass and muscle strength and / or function in the elderly.

Ischemia / reperfusion injury underlies health issues such as heart attack, stroke, and numerous other ailments including diseases of the kidney, liver, skeletal muscles, and more.

Prof. Maria Luisa Brandi MD, Professor of Endocrinology and Metabolic Diseases at the University of Florence, Italy, lead author and Chair of the IOF Working Group on Skeletal Rare Diseases stated, «Due to the rarity of these diseases diagnosis is a challenge, and most patients — who are often children — currently have few choices when it comes to therapy.

To date, the diagnosis of rare skeletal diseases is based primarily on clinical phenotype and radiographic analysis.

Still the study is «an important first step to show that manipulating AMPK - nNOS signaling at least has the potential to help muscle function in muscular dystrophy,» says Michele whose lab at the University of Michigan Cardiovascular Research Center focuses on inherited forms of skeletal and cardiac diseases.

After careful extraction of genetic material from victims» teeth, a team of researchers has sequenced 99 percent of the Plague's genome — the first whole - genome reconstruction of a disease from skeletal remains.

Among priorities in 2011, the government intends to make headway against two diseases that hit China hard: hepatitis B and skeletal fluorosis, which is caused by inhalation of fluorine given off by home coal stoves.

Skeletal dysplasia is a group of rare diseases that afflict skeletal growth through abnormalities in bone and caSkeletal dysplasia is a group of rare diseases that afflict skeletal growth through abnormalities in bone and caskeletal growth through abnormalities in bone and cartilage.

A disease of bone marrow failure, the condition can cause skeletal deformities and increases cancer and anemia susceptibility.

Human skeletal biologist Simon Mays from the University of Southampton, UK, was unable to deduce the cause of death from the skeleton and he speculates that Stonehenge Man died of an infectious disease that killed too quickly to leave a trace on bones.

We suggest these observations will have therapeutic implications for skeletal myopathies and systemic diseases such as diabetes and obesity and for the aged population, in which reduced endurance impacts mortality and activities of daily living (57); as well as societal implications in terms of altering athletic performance.

They usually die of heart failure or lung disease, so delivering dystrophin to the skeletal muscles — even if that were possible — would not help much.

A major aspect of our work centers around transcriptional and epigenetic control of plasticity in cardiomyocytes, smooth muscle, and skeletal muscle in physiology and disease.

In his graduate research, Linsley discovered the gene Stac3 is a component of the excitation - contraction machinery in skeletal muscle and the mechanism by which mutations in that gene cause Native American Myopathy, a rare but devastating congenital disease.

Skeletal Biology Development and Disease Study Section, Center for Scientific Review, National Institutes of Health, 2016 - 2020

It is characterized by the wasting of skeletal muscles and caused by progressive degeneration of nerve cells in the spinal cord; the disease leads to increasing muscular weakness, atrophy and premature death due to respiratory problems.

Our laboratory focuses on understanding gene regulation in the cardiovascular system, skeletal muscle, and other metabolic tissues, with the ultimate goal of finding novel therapeutic strategies to prevent and treat cardio - metabolic and - myopathic diseases.

Skeletal fragility affects 40 - to - 50 percent of adults with PKU and 33 percent of children with the disease.

Defined basic principles of how skeletal and cardiac muscle cells adapt to changing physiological demands associated with exercise or disease states.

He added that this finding also means that muscular dystrophy (MD) researchers who are attempting to develop genetic therapies must target defective smooth muscle as well as the malfunctioning skeletal muscle most often associated with the crippling effects of the disease.

It aims at understanding how mechanisms involved in the control of skeletal muscle Ca2 + + homeostasis and excitation - contraction (EC) coupling operate under normal and disease conditions.

AFM - Téléthon (2015 - 2017): Physiopathology of voltage - activated Ca2 + influx in normal and diseased skeletal muscle (coordinator).

Spinal muscular atrophy (SMA) is a genetic, motor neuron disease characterized by the wasting of skeletal muscles.

Better understanding of mechanisms underlying skeleton development, adult maintenance, and diseases has led in recent years to new and improved treatments for osteoporosis and a few other conditions, but today most skeletal diseases remain untreatable or incompletely treatable.

Skeletal diseases can drastically impact the quality of life of affected individuals.

Research Interests: Molecular control of cell fate from stemness to differentiated skeletal and neuronal cell types; SOX transcription factors; skeletal malformation and degeneration diseases; intellectual disability and autism spectrum disorders; mouse genetic models; human pluripotent stem cell differentiation models in vitro

Thus, successful accomplishment of the project will allow the fellow to launch a promising research career in stem cell and molecular genetics relevant to inherited and acquired human skeletal diseases.

New SOXC projects in the laboratory are addressing the roles of SOXCs in other skeletal cell types in development, in adult skeleton maintenance, and in human diseases.

Like Lou Gehrig's disease, SMA is a neuromuscular illness that attacks nerve cells of the spinal cord and causes skeletal muscles to waste away.

Plenary Lecture: Adaptations of the Heart: Traditional and Non-Traditional Research Approaches Leslie Leinwand, Ph.D. of the Department of Molecular, Cellular and Developmental Biology at the University of Colorado, Boulder will discuss cardiac and skeletal muscle development and function, gene therapy and cardiac genetic disease.

This expertise includes diagnosis as well as surgical and nonsurgical treatment for a wide range of problems such as skeletal deformities, musculoskeletal diseases, and traumatic injuries.

Dr. Lee is the Robert and Janice McNair Endowed Chair, Professor, and Chairman of the Department of Molecular and Human Genetics, Director of the Center for Skeletal Medicine and Biology at Baylor College of Medicine, and co-Director of the Texas Medical Center Bone Disease Program of Texas.

The authors highlight the successful application of both induced pluripotent stem cells and embryonic stem cells for this first example of the in vitro formation of functional and mature skeletal muscle tissue, thereby also establishing the potential for patient - specificity in disease modeling, drug development, and possible muscle repair.