His primary interest is in understanding the processes
of skeletal muscle regeneration and fibrosis, the impact of physical stress on the immune system and the preventive aspect of physical activity and exercise.
Not exact matches
DMD patients experience ongoing cycles
of muscle destruction and
regeneration that promote inflammation, fibrosis (scarring), and the loss
of skeletal and cardiac
muscle function.
Results
of a study conducted by researchers at the University
of Pittsburgh School
of Medicine and the McGowan Institute for Regenerative Medicine showed significant improvement in strength and range
of motion, as well as evidence for
skeletal muscle regeneration, in 13 patients who were surgically implanted with bioscaffolds derived from pig tissue to treat
muscle injuries.
We investigated the role
of Srf in two cellular compartments
of mouse
skeletal muscle (myofibers and adult
muscle stem cells) upon different perturbation
of muscle homeostasis (hypertrophy, atrophy,
regeneration).
These endogenous
muscle stem cells promote
regeneration of skeletal muscles after injury and that participate in adaptation to exercise.
However, Setd7 expression increased with the progression
of myogenesis in vitro indicating the potential importance
of this event for
skeletal muscle development and
regeneration in vivo.
AMPKalpha1 regulates macrophage skewing at the time
of resolution
of inflammation during
skeletal muscle regeneration
Montarras D, Morgan J, Collins C, et al., Direct Isolation
of Satellite Cells for
Skeletal Muscle Regeneration.
Currently, back at the University
of warsaw, she heads the Department
of Cytology which investigates the potential
of various stem cells to differentiate into myoblasts and to participate in the
regeneration of skeletal muscle.
Ju YM, Atala A, Yoo JJ, et al., In situ
regeneration of skeletal muscle tissue through host cell recruitment.
A new study from the Harvard John A. Paulson School
of Engineering and Applied Sciences (SEAS) and the Wyss Institute for Biologically Inspired Engineering at Harvard University suggests that mechanically - driven therapies that promote
skeletal muscle regeneration through direct physical stimulation could one day replace or enhance drug and cell - based regenerative treatments.
Satellite cells (SCs) are a heterogeneous population
of stem and progenitor cells that have been demonstrated to play a pivotal role in
skeletal muscle (SkM)
regeneration.
The clinical study from OSUWMC proved that PrimaVie promoted
skeletal muscle adaptation through upregulation
of ECM - related genes that control
muscle mechanotransduction properties, elasticity, repair, and
regeneration.