Sentences with phrase «of skeletal muscle stem cells»

Title: Regulation of skeletal muscle stem cell behaviour by Pax3 and Pax7 Authors: Lagha M, Sato T, Bajard L, Daubas P, Esner M, Montarras D, Relaix F, Buckingham M Date: 2008 Publication Details: Cold Spring Harbor Symposium on Quantitative Biology 2008.

Not exact matches

One of the molecular mysteries hindering development of regenerative therapy for muscles is uncovering the precise genetic and molecular processes that cause skeletal muscle stem cells (called myoblasts) to fuse and form the striated muscle fibers that allow movement.

Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.

Researchers have isolated stem cells from only some of the body's organs and tissues, including the blood, brain, skeletal muscle, heart muscle and most recently from skin.

The hamburger was grown in Post's lab using bovine skeletal muscle stem cells, collected from a piece of fresh beef.

«This is a clean demonstration that the physiological and metabolic benefits of exercise radiate to skeletal muscle satellite cells, the adult stem cells responsible for repair after injury, even in senescent animals,» said Thoru Pederson, Ph..

As stem cells continue their gradual transition from the lab to the clinic, a research group at the University of Wisconsin — Madison has discovered a new way to make large concentrations of skeletal muscle cells and muscle progenitors from human stem cells.

We investigated the role of Srf in two cellular compartments of mouse skeletal muscle (myofibers and adult muscle stem cells) upon different perturbation of muscle homeostasis (hypertrophy, atrophy, regeneration).

These endogenous muscle stem cells promote regeneration of skeletal muscles after injury and that participate in adaptation to exercise.

Characterized other proteins and pathways that modulate proliferation and differentiation of myogenic stem cells, hypertrophic growth of the heart, mitochondrial biogenesis and fiber type — specific gene expression in skeletal muscles.

Abstract We discovered that a subset of satellite cells in skeletal muscle are self - renewing stem cells that give rise to myogenic progenitors through asymmetric apical - basal cell divisions.

Using mouse skeletal muscle stem cells as a model, we show that accumulating transcripts specifying the myogenic program are not translated in quiescent satellite cells, but are repressed by the action of microRNAs and RNA binding proteins.

p38 MAPK signaling underlies a cell - autonomous loss of stem cell self - renewal in skeletal muscle of aged mice.

Research is specially centered on stem cells of skeletal muscle (i.e., satellite cells).

Title: A Subpopulation of Adult Skeletal Muscle Stem Cells Retains All Template DNA Strands after Cell Division Authors: Rocheteau P, Gayraud - Morel B, Siegl - Cachedenier I, Blasco MA, Tajbakhsh S Date: January 2012 Publication Details: Cell.

Currently, back at the University of warsaw, she heads the Department of Cytology which investigates the potential of various stem cells to differentiate into myoblasts and to participate in the regeneration of skeletal muscle.

The decline in skeletal muscle function associated with human ageing can be ascribed to an increasing number of mutations in satellite cells — the resident stem cells of skeletal muscle.

The authors highlight the successful application of both induced pluripotent stem cells and embryonic stem cells for this first example of the in vitro formation of functional and mature skeletal muscle tissue, thereby also establishing the potential for patient - specificity in disease modeling, drug development, and possible muscle repair.

With their guidance, Williams transformed stem cells into skeletal muscle cells to help create a model of amyotrophic lateral sclerosis (ALS).

Review of «Engineering human pluripotent stem cells into a functional skeletal muscle tissue» from Nature Communications by Stuart P. Atkinson

Satellite cells (SCs) are a heterogeneous population of stem and progenitor cells that have been demonstrated to play a pivotal role in skeletal muscle (SkM) regeneration.

The recent recognition that de novo lipogenesis might have relevance for lipid homeostasis in skeletal muscle stems from the realization that Sterol regulatory element binding protein - 1c (SREBP - 1c), a member of the family of transcription factors that regulate the expression of genes involved in lipid storage in liver and adipose tissue, is also present in skeletal muscle at a level close to that observed in the liver, 41,42... [M] ost fascinating are the very recent demonstrations that glucose alone (in the absence of insulin) can stimulate de novo lipogenesis in skeletal muscle cells....