Sentences with phrase «of small clinical trials»

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

A variety of small clinical trials have also suggested that omega - 3s (at doses ranging from one to four grams) may alleviate the symptoms of depression, schizophrenia, and bipolar disorder, as well as improve patients» response to conventional medicines.

On September 11, the company announced the completion of a small clinical trial of its adhesive: The sealant immediately stopped blood flow after an artery - clearing operation in about 85 percent of 22 participants.

Some multiple sclerosis patients may benefit if their immune system is selectively suppressed, according to the results of a small clinical trial performed at Harvard University.

Not exact matches

Some small studies have suggested that synbiotics could provide benefits to a range of other conditions influenced by the gut microbiome as well, including obesity, diabetes, and non-alcoholic fatty liver disease, but larger - scale clinical trials focusing on each of those conditions are needed.

And it doesn't really do what it's supposed to: When Sprout conducted clinical trials, women only reported a small increase in the number of times they had satisfying sex — around one additional time per month.

As an exec at Shire (shpg), which with $ 6 billion in revenue is one of the smaller Big Pharmas, he spent months persuading leaders and commercial and supply - chain people to launch a clinical trial for the ADHD drug Vyvanse to treat binge eating.

To achieve this goal, several approaches are envisaged: identifying small populations with severe disease where a medicine's benefit - risk balance could be favorable; making more use of real - world data where appropriate to support clinical trial data; and involving health technology assessment bodies early in development to increase the chance that medicines will be recommended for payment and ultimately covered by national healthcare systems.

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

In the randomized clinical trial, 230 adults with fibromyalgia received one of three treatments, each of which was presented for eight weekly sessions to small groups of patients.

Success with these models led to a small phase I clinical trial in which an individual's good bacteria with antimicrobial activity was grown, formulated in a skin cream and applied once to the forearm of the eczema patient infected by S. aureus.

The first controlled, but controversial and small, clinical trial of giving young blood to people with dementia has reported that the procedure appears safe.

The small trial was not randomized, double - blinded or placebo - controlled — the combination of which is considered the gold standard in clinical research.

Researchers only discovered this process in the late 1990s, but they've already begun dozens of clinical trials to gauge whether infusing patients with these small RNAs works against a range of diseases, from lung infections to liver cancer to age - related macular degeneration, a sight - stealing condition that mainly affects people over the age of 50.

Most clinical trials show that cutting out 1,000 milligrams of sodium from a diet, a relatively large amount, results in only a small drop in blood pressure on average, Cohen says.

Using simple statistics, without data about published research, Ioannidis argued that the results of large, randomized clinical trials — the gold standard of human research — were likely to be wrong 15 percent of the time and smaller, less rigorous studies are likely to fare even worse.

An advantage of small - molecule PPF — which has been previously used in clinical trials in an attempt to treat Alzheimer's disease and dementia — is that it can penetrate the blood - brain barrier and reach the tumor.

However, what our trial has shown is that although this is still the case, the proportion of women who will actually have a recurrence without radiotherapy is very small (less than 5 percent), five years after treatment,» said Ian Kunkler, F.R.C.R., professor of clinical oncology at the Edinburgh Cancer Research Center in the University of Edinburgh.

The cost of these large QT interval clinical trials is not trivial either, while the data collected about QT interval is again only a small piece of the story when investigating proarrhythmic risk of a drug.

This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection,» Dr. Oxana Denisova says.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

The spat involves a June 2001 paper in The American Journal of Psychiatry on a small clinical trial of the antidepressant Paxil that was funded by GlaxoSmithKline (GSK) and the National Institute of Mental Health.

The reliably high percentage of those who develop viremia following exposure to this challenge virus is another advantage — when most or all volunteers develop viremia or other signs of infection, clinical trials can enroll relatively small numbers of people but still achieve answers to such questions as whether a candidate vaccine protects against infection, she noted.

Her research at Stanford University has contributed to the development of a small molecule peptide that is currently in Phase IIA clinical trials for AD.

«Previous studies suggest that reducing heart fat is feasible through weight loss or weight management, but these studies only looked at small numbers of people and there have been no clinical trials linking cardiovascular outcomes with heart fat changes due to weight management interventions.

Investigative studies of human biology with an emphasis on disease, including small clinical trials

The study, published in the July issue of the journal Epidemiology, offers benefits over typically used randomized clinical trials, as such studies are often too small to identify rare side effects or may be performed in a group of patients who do not take other types of medications or have other conditions that could skew the drug's effect in a broader group following approval.

In a small phase I and II clinical trial, Johns Hopkins researchers and colleagues elsewhere found that the high - fat, low - carbohydrate ketogenic diet was a safe and effective treatment option for the majority of adults experiencing a relatively rare, often fatal and always severe form of epilepsy marked by prolonged seizures that require medically induced comas to prevent them from further damaging the body and the brain.

This approach, however, differs from liquid biopsies, including commercial tests, which only profile a relatively small portion of the genome in patients already diagnosed with cancer for the purpose of helping monitor the disease or detect actionable alterations that can be matched to available drugs or clinical trials.

More formally, Dr. White and physician - researchers have begun testing the combination of morphine and a close relative of carbamazepine with patients in a small clinical trial at the Indiana University Melvin and Bren Simon Cancer Center.

Women age 25 - 65 who have been diagnosed with HPV 16 or HPV 18 are needed to participate in a small Phase I tolerability clinical trial of GTL001 with only a three - month follow - up period.

However, despite this success, clinical trials using these antibodies caused inflammatory side effects in the brain of Alzheimer's patients, in particular amyloid - related imaging abnormalities (ARIA), which results in small bleeds and dangerous brain swelling.

Brian Madeux, the first patient in what will be a small clinical trial has a mild form of the disease, but nevertheless has had more than two dozen operations as a result, AP reports.

Although these platforms can be used successfully for small - scale expansion of hMSCs, other platforms will be required to generate the quantity of cells required to support the increasing number of clinical trials utilizing hMSCs and the subsequent large - scale production.

Some research efforts are closer to clinical implementation, including developing improvements in clinical management of rare diseases and trials of small molecule therapies for inherited and mosaic genetic disorders.

A randomized, phase II trial showed improved progression - free survival in small - cell lung cancer with maintenance sunitinib vs placebo following standard chemotherapy, according to results presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

Table 1: Selection, Design & Construction of HSV - based Oncolytic Viruses Table 2: Selection, Design & Construction of Adenovirus - based Oncolytic Viruses Table 3: Selection, Design & Construction of Vaccinia Virus - based Oncolytic Viruses Table 4: Selection, Design & Construction of Vesicular Stomatitis Virus - based Oncolytic Viruses Table 5: Selection, Design & Construction of Newcastle Disease Virus - based Oncolytic Viruses Table 6: Selection, Design & Construction of Various Virus - based Oncolytic Viruses Table 7: Current Company - Sponsored Clinical Trials of T - Vec Table 8: Clinical Trials of ColoAd1 Table 9: Clinical Trials with JX - 594 Table 10: Clinical Trials with GL - ONC1 Table 11: Clinical Trials of CAVATAK (CVA21) Table 12: Clinical Trials with MV - NIS Table 13: Overview of Oncolytic Viruses by Development Phase & Virus Family Table 14: Profile of Approved and Marketed Oncolytic Viruses Table 15: Pivotal Study Design of Oncolytic Viruses in Late Stage Development Based on Previous Clinical Results Table 16: Approved Indications of Immune Checkpoint Inhibitors Table 17: Active Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 18: Planned Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 19: Active or Planned Clinical Studies of Oncolytic Viruses in Combination with Other Anti-Cancer Therapeutics Table 20: Pattern of Transgenes in Oncolytic Viruses in Relation to Development Phase Tables 21a and 21b: Indications and Frquency and Way of Administration of Oncolytic Viruses in Active and / or Positive Completed Clinical Studies Table 22: Small and Medium Pharma & Biotech as Partner for Regional Co-Development of Oncolytic Viruses Table 23: Immuno - Oncology Portfolio of Major Pharma & Biotech with Interest in Oncolytic Viruses Table 24: Interests of Major Pharma & Biotech in Oncolytic Viruses Table 25: First Generation Oncology Virus Companies and their Sources of Technology Table 26: Second Generation Oncology Virus Companies and their Sources of Technology Table 27: Third Generation Oncology Virus Companies and their Sources of Technology Table 28: Fourth Generation Oncology Virus Companies and their Sources of Technology Table 29: Grants, Credits & Donations Table 30: Financing by Venture Capital, Private Equity and Other Private Placements Table 31: Collaboration & Licensing Agreements Table 32: Companies Listed on Stock Exchange & Offerings Table 33: Mergers & Acquisitions

Small, focused clinical trials are possible for certain B - cell malignancies such as Diffuse Large B - Cell Lymphoma in which patients can be stratified based on NF - kB activation status and / or presence of mutations known to activate NF - kB.

Immunologic checkpoint blockade with anti — cytotoxic T - lymphocyte — associated antigen 4 (CTLA - 4) or anti — programmed death 1 (PD - 1) / programmed death ligand 1 (PD - L1) agents seems to have some degree of clinical efficacy in advanced mucosal melanoma, although data are limited to smaller retrospective series or subset analyses of prospective trials.

Clinical benefits of lentiviral vectors have been observed in small trials for other diseases, including the common hematopoietic disorders

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

Texas Children's Cancer Center is a member of the COG Phase I Consortium, a small and select group of institutions that administer Phase I clinical trials of drugs in early development.

A Clinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other popuClinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other popuclinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other populations.

A total of 13 Dream Team clinical trials are active right now, for patients with bladder cancer, kidney cancer, prostate cancer, triple - negative breast cancer, gastric cancer, pancreatic cancer, small cell and non-small cell lung cancer, sarcoma, and melanoma, and seven more trials are planned.

Rethinking the traditional drug development process for rare diseases will be critical, including trial design for small populations, real - world evidence collection, stronger patient engagement for data collection and definition of clinical end - points.

«Regenerative medicine therapies are already benefiting small groups of patients through clinical trials,» said Atala.

Omecamtiv mecarbil is a selective, small - molecule currently being studied in a Phase 3 clinical trial of ~ 8000 patients as a potential treatment for heart failure with reduced ejection fraction in collaboration with Amgen and in partnership with Servier.

Study designs, both large scale clinical trials as well as smaller mechanistic studies, will take into consideration and take advantage of the heterogeneity of clinical phenotypes in the study design.

The technique is also inefficient, correcting only a small percentage of gene mutations, and transplantation success has proven rare in clinical trials testing gene therapy to treat beta thalassemia.