Sentences with phrase «of small genes»

«This is important biotechnologically, because if you look at if from the angle of genome editing, the delivery of small genes into cells is much easier than the delivery of large genes,» said Rotem Sorek of the Weizmann Institute of Science in Israel who was not involved in the work.

In consideration of the small gene pool, stud dog owners must use restraint and judgment in the repeated use of a stud dog.

(All responsible breeders carefully place their dogs in new homes, but breeders of rare breeds are even more finicky about where their pups go because they are guardians of a small gene pool and need to make sure that all breedable dogs are kept intact and that buyers understand the consequences of owning a pet that is also the repository of genes from that limited pool.)

Not exact matches

Gene therapy has the potential to save lives, but the pool of people who suffer from the orphan diseases, or conditions that pharmaceutical companies have historically ignored, is relatively small.

The Chiesi fund will consider a wide range of opportunities, from traditional small molecules and biologics, to gene therapies and cell therapies, to diagnostic and disease management technologies.

Suppose it could be shown from past letters that my father met my mother because he missed his train, and so caught the one on which he found this beautiful young woman sitting; suppose, further, that a super-computer could show that some of my genes can be traced back to a small creature scrabbling about in the Triassic mud.

Those with naturally bigger teeth will be better able to utilize this food resource, allowing them to survive when members of their group with smaller teeth starve, thus leaving the big toothed ones to prosper and reproduce, thus increasing the frequency of big teeth genes in their gene pool.

And thd gods closed their games: But keep in mind there are gods of doping from using small doses of, believe it or not, strycnine (Smithsonian's review of Olympic doping) to the latest, gene manipulation.

This is nature in action and a small part of the inevitable process that will remove religiousness from the gene pool.

Even if Noah impregnated all of them at once, or his sons did their respective wives, and then they all repeated the process 14 years later (give or take) when the 1st offspring became fertile, how could different races with distinct physiological adaptation arise from such a small, virtually identical gene pool 4,000 years ago?

These accessions hold a virtually untapped reservoir of genes / traits that can be used to make rice cultivation more sustainable, with a smaller environmental footprint.

It «s rather annoying my fathers side of the family all have huge breasts and I have been cursed with my mothers genes in the small breast department.

Some babies are naturally larger or smaller because of their genes.

They discovered an orchestrated switching on and off of various genes as the mammary gland transitions from secreting small amounts of immunity - boosting colostrum in the first days after giving birth to the copious production of milk in mature lactation.

Frankencell J. Craig Venter's attempt to create an artificial cell containing the smallest possible number of essential genes.

For a very small number of genes, though, people inherit only one working copy; the other copy is turned off, forever silenced.

To identify gene variants associated with musical aptitude, Irma Järvelä at the University of Helsinki, Finland, and colleagues analysed the genomes of 767 people assessed for their ability to detect small differences between the pitch and duration of a sound, and musical pattern.

Like many women in her situation, Iona imagined the gene, if she carried it, as a tiny bit of cancer in itself, but one so small that it might be repressed into nothingness.

Standard forms of CRISPR gene drives, as the tools are called, can make tweaked DNA race through a population so easily that a small number of stray animals or plants could spread it to new territory, predicts a...

Fortunately, humans have a nearly identical copy gene called SMN2, however, SMN2 normally only makes a small amount of the correct SMN protein.

Standard forms of CRISPR gene drives, as the tools are called, can make tweaked DNA race through a population so easily that a small number of stray animals or plants could spread it to new territory, predicts a computer simulation released November 16 at bioRxiv.org.

These are small molecules that can affect the way genes work, and the types of microRNA in our blood are known to vary according to age.

The goal of early SMA drug discovery programs has been to identify small molecules that induce the SMN gene to produce sufficient levels of protein to improve motor neuron functioning in affected patients.

These fatty molecules have shown promise as delivery vehicles for RNA interference, a process that allows disease - causing genes to be turned off with small strands of RNA.

Biologists now know that the genome sequence holds only a small part of the answer, and that key elements of development and disease are controlled by the epigenome — a set of chemical modifications, not encoded in DNA, that orchestrate how and when genes are expressed.

Starting just before conception, Jirtle and Waterland fed a test group of mother mice a diet rich in methyl donors, small chemical clusters that can attach to a gene and turn it off.

«We are very excited about the prospect of using these more physiologically relevant cell - based models for gene and small molecule drug discoveries,» says Dr. Andrew Liu, Assistant Professor of Biology at the University of Memphis.

For instance, a team led by Sheng Ding of the Scripps Research Institute in La Jolla is screening for small - molecule drugs that can substitute for the reprogramming genes.

Damage to human chromosome 9 (of the cell's 24 pairs) where the gene that codes for E-NTPDase2 resides is known to cause eye and brain defects, such as microphthalmia — literally, small eyes.

A class of small molecules found in grapes, red wine, olive oil, and other foods extends the life of yeast cells by approximately 70 % and activates genes known to extend life span in laboratory animals.

The overexpression of an important gene that regulates energy metabolism can cause a severe shortening of lifespan in male fruit flies but has only a small negative effect on lifespans of female fruit flies, according to new research from North Carolina State University.

Bloom, of Albert Einstein College of Medicine in New York City, and Small, of Stanford Medical Center in Palo Alto, California, also express hope that more studies could reveal a gene in the myobacterium for virulence or transmissibility.

It is a type of branched DNA ISH that uses pairs of «Z - probes,» which are highly specific to target genes, but also small enough to easily diffuse into the tissues under study.

The research centres on miRNAs, small molecules that have an important role in turning genes on and off in different parts of the body.

«The next step is to identify antibodies and small - molecule drugs that can successfully target Helios or genes in the Helios pathway,» says the study's lead author, Hye - Jung Kim, PhD, of Dana - Farber.

Northwestern Medicine scientists have identified a small RNA molecule called miR - 182 that can suppress cancer - causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor.

Dr. Satish Rattan, Professor in the Department of Medicine, Division of Gastroenterology and Hepatology at Jefferson's Sidney Kimmel Medical College, together with Drs. Jagmohan Singh and Ipsita Mohanty, used altered copies of the body's own genetic make - up — small RNA fragments (microRNAs) that regulate the target gene RhoA / ROCK — in order to strengthen or weaken the muscle tone of the sphincter.

But with smaller parties standing to gain political influence, battles over issues such as the regulation of gene - edited organisms and how to cut greenhouse - gas emissions could grow fiercer.

The policy — in the form of first Office Actions on a series of applications for patents on expressed sequence tags, ESTs — could greatly complicate basic gene therapy research by substantially allowing patents for small sequences of a gene that may later be used by the patent holder to corner ownership and uses of entire genes.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

These epigenetic modifications do not change the genetic code, but may contribute to the inhibition of gene expression, causing the cells to produce smaller amounts of the corresponding proteins.

This pressure, together with possible interbreeding with migrating groups of smaller - brained peoples, may have led to a gradual decrease in the frequency of the Boskop genes in the growing population of what is now South Africa.

Intriguingly, DNA in many of the placenta samples has the same imprinting abnormality seen in Silver - Russell, but a dampened down version of it — perhaps a smaller stretch of the gene is affected, or gene expression is less abnormal.

The pieces of the dead guide activators are small enough to fit in gene therapy viruses.

They also gave back thousands of ancient African gene variants that Eurasians had lost when their ancestors swept out of Africa in small bands, perhaps 60,000 to 80,000 years ago.

The researchers assessed LPLD - related acute abdominal events that required hospital care in a small group of patients treated with a single dose of the gene therapy product Glybera ®.

The genome shows that octopuses have the same small repertoire of neurotransmission genes as lower mollusks.

Face shape, which would be the holy grail, is in the distant future — we've only found the first five genes, and the effects of those genes are very small.

The first clue that digits and penises might be birds of a feather came in 1991, when a team led by developmental biologist Denis Duboule of the University of Geneva and Pierre Chambon of the Institute for Genetics and Molecular and Cellular Biology in Strasbourg, France, found that some mice with a mutated gene, called hoxd13, had abnormally small digits and malformed penises.

Research published this month in Nature Neuroscience identified a surprisingly small set of molecular patterns that dominate gene expression in the human brain and appear to be common to all individuals, providing key insights into the core of the genetic code that makes our brains distinctly human.