Sentences with phrase «of small molecule»

Research Associate specializing in the developing of purification processes for therapeutic proteins as well as high throughput characterization and screening assays for the discovery of small molecule candidates

ACADIA Pharmaceuticals Inc. is focused on the development and commercialization of small molecule drugs for the treatment of central nervous system disorders.

It focuses on the development and commercialization of small molecule drugs for the treatment of central nervous system disorders.

Citation: Han Y, Miller A, Mangada J, Liu Y, Swistowski A, Zhan M, et al. (2009) Identification by Automated Screening of a Small Molecule that Selectively Eliminates Neural Stem Cells Derived from hESCs but Not Dopamine Neurons.

Phenotypic screening of small molecule libraries using iPSC - based models to identify novel drug candidates and disease mechanisms.

eFFECTOR is pioneering a new class of small molecule drugs that act by selectively regulating translation, also known as protein synthesis.

The discovery of small molecule regulators (activators or inhibitors) of epigenetic modification enzymes provides researchers with pharmacological tools with which to investigate the biological consequences of chromatin modifications.

How binding of a small molecule can increase the performance of a muscle by promoting an increase in myosin motor force was unclear.

Challenged to identify the biological context in which these genes act, the researchers set out to provide the necessary basis for the next steps of small molecule discovery and the development of early stage therapeutics.

The U.S. Patent and Trademark Office has announced that it will grant a patent to MDI Biological Laboratory scientists Voot P. Yin, Ph.D., and Kevin Strange, Ph.D., and their collaborator Michael Zasloff, M.D., Ph.D., for use of the small molecule MSI - 1436 to stimulate the repair and regeneration of heart tissue damaged by injuries such as a heart attack.

In 1994, Schreiber and co-workers discovered that the proteins FKBP12 and mTOR are the simultaneous targets of the small molecule rapamycin, now approved for use as an immunosuppressant drug given to patients after organ transplantations to help prevent rejection.

However, this study tells us that if there is any way we can enhance inhibitory neuron function in the hippocampus, like through the development of small molecule compounds, it may be beneficial for Alzheimer disease patients.»

Discovery of small molecule CXCR4 antagonists.

Dr. Ding's work revolves around chemical reprogramming — the use of small molecule drug mixtures to coax fibroblasts into becoming a variety of other cell types.

Finally, we show that addition of small molecule inhibitors of eIF2α dephosphorylation to muscle stem cell cultures permits their ex vivo expansion and engraftment into a preclinical mouse model of Duchenne muscular dystrophy.

Nuclear domain «knock - in» screen for the evaluation and identification of small molecule enhancers of CRISPR - based genome editing.

Some research efforts are closer to clinical implementation, including developing improvements in clinical management of rare diseases and trials of small molecule therapies for inherited and mosaic genetic disorders.

The identification of disease signatures will enable screens of small molecule libraries to delineate molecular targets that modulate these disease signatures and identify new diagnostic and therapeutic leads for schizophrenia and bipolar disorder.

MedImmune is the global biologics research and development arm of AstraZeneca, a global, innovation - driven biopharmaceutical business that focuses on the discovery, development and commercialization of small molecule and biologic prescription medicines.

The emerging field of DNA - encoded chemical library allows us to perform selection of small molecule compounds.

Identification of small molecule inhibitors of Cisplatin - induced hair cell death: results of a 10,000 compound screen in the zebrafish lateral line.

The initiative will also allow the CMI to foster new partnerships between academia and industry, and utilize the individual strengths that each possess to expedite the early stages of small molecule drug discovery.

«This is the first example of a small molecule — which can be easily prepared and made on a large scale — that shows substantive post-exposure protection against Ebola virus in nonhuman primates,» Bavari commented.

Small peptides have the benefits of small molecule drugs, like aspirin, and large antibody therapies, like rituximab, with fewer drawbacks.

Therefore, the site of attachment on the structural scaffold was all - important in determining the bioactivity of the small molecule.

In addition to Disney and Velagapudi, authors of the study, «Design of a Small Molecule Against an Oncogenic Non-coding RNA,» were Michael D. Cameron, Christopher L. Haga, Laura H. Rosenberg, Marie Lafitte, Derek Duckett and Donald G. Phinney of TSRI.

Her research at Stanford University has contributed to the development of a small molecule peptide that is currently in Phase IIA clinical trials for AD.

«This can be accomplished because one advantage of these types of small molecule drugs is that they readily cross the blood - brain barrier and actually prefer to act in the brain,» Rissman said.

But scientists at the Lewis Katz School of Medicine at Temple University (LKSOM) now think they can help overcome that problem, thanks to their discovery of a small molecule that selectively kills BRCA - deficient cancer cells by blocking the activity of an alternative DNA repair pathway.

But, says Michael Varney, head of the small molecule drug discovery group at Genentech, those hiring trends are about to change: «For us, over the next 3 years, we'll hire more medicinal chemists and more process and scale - up chemists than we will analytical chemists.»

«The Holy Grail of small molecule research is to know which protein the drug directly binds to.

An argument formally similar to Eigen's quasi-species concept has recently been shown11d to provide a satisfactory account of the occurrence of major structural changes on binding of a small molecule to a specific antibody.

Breakthrough: IBM has simulated the electronic structure of a small molecule, using a seven - qubit quantum computer.

The RNA molecule is constructed of smaller molecules called nucleotides.

In their ACS Central Science study, Disney and his colleagues used DNA sequencing to evaluate thousands of small molecules as potential drug candidates.

Other collaborations that are currently being discussed focus on the development of small molecules that could disrupt «kidney» (Malphigian tubule) function in mosquitoes, on the differences in the ability to transmit disease among various populations of Aedes aegypti and other mosquitoes, and on advances in the surveillance of adult mosquitoes.

Antibiotics typically take the form of small molecules that each interfere with one very specific process inside a bacterial cell.

AAAS Fellow Joachim Frank and AAAS member Richard Henderson were awarded the 2017 Nobel Prize in Chemistry for developing a type of electron microscopy that provides detailed views of the structures of the smallest molecules of life, the Royal Swedish Academy of Sciences announced Oct. 4.

Still eager to make an MIS - like contraceptive for all women that is cheap and easy to use, perhaps as a pill, the researchers are searching libraries of small molecules to find one that mimics the action of MIS.

A class of small molecules found in grapes, red wine, olive oil, and other foods extends the life of yeast cells by approximately 70 % and activates genes known to extend life span in laboratory animals.

One of the most important early applications will be to study the chemistry of small molecules or simple reactions, by using quantum computers to simulate the quantum mechanics of chemical systems.

A panel of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania.

We don't need to use a cocktail of small molecules, growth factors or other supplements to create a population of bone cells from human pluripotent stem cells like induced pluripotent stem cells,» Varghese said.

They demonstrated that their machine could build 14 different classes of small molecules, including ones with difficult - to - manufacture ring structures, all using the same automated building - block assembly.

The acidity of urine — as well as the presence of small molecules related to diet — may influence how well bacteria can grow in the urinary tract, a new study shows.

The large molecules — long chains of smaller molecules bonded together, form any synthetic clothing you might be wearing, rubbers and glues, and anything made of plastic.

To do so, they treated melanoma cells with a panel of small molecules and identified JNJ - 7706621 (JNJ) as the best inhibitor of cyclinB1 / cdk1.

In the latest issue of PLOS Neglected Tropical Diseases scientists from Colorado State University explore the use of small molecules in patient serum for diagnosis of dengue fever and potentially predicting progression to the severe disease.

They put this technique to work in search of small molecules that specifically blocked the C. difficile toxins» protease activity.

As the microbes metabolize food, they produce an astonishing number of small molecules, chemicals and hormones that circulate in a host and can influence health in an animal.