Sentences with phrase «of small molecule compounds»

However, this study tells us that if there is any way we can enhance inhibitory neuron function in the hippocampus, like through the development of small molecule compounds, it may be beneficial for Alzheimer disease patients.»

The emerging field of DNA - encoded chemical library allows us to perform selection of small molecule compounds.

Not exact matches

The technology is allowing basic scientists and small companies to generate impressive libraries of molecules, on a scale once reserved for big pharma, and select from them the most useful compounds.

«We have discovered a small molecule compound that shows a profound and prolonged effect on autism - like social deficits without obvious side effects, while many currently used compounds for treating a variety of psychiatric diseases have failed to exhibit the therapeutic efficacy for this core symptom of autism,» said Zhen Yan, PhD, professor in the Department of Physiology and Biophysics in the Jacobs School of Medicine and Biomedical Sciences at UB, and senior author on the paper.

To try to develop a more sensitive probe for isolating individual peptides — short strands of amino acids — from a pool of similar molecules, a team led by chemist Clark Still of Columbia University 4 years ago synthesized small organic compounds that selectively fish out peptides dissolved in chloroform.

3BP, part of a class of compounds known as small molecule drugs, was first studied as an anti-cancer agent more than a decade ago at Johns Hopkins by biochemists Young Hee Ko and Peter Pedersen, together with radiologist Jeff Geschwind.

In this study, the researchers screened a library of 200,000 small molecule compounds to identify potential inhibitors of Ebola virus RNA synthesis.

Our guide is a small, «elegant» molecule called carbon disulfide — a compound that is a key ingredient in the making of viscose (better known as rayon) and is also insidiously toxic, having devastated the minds and bodies.

«A long - standing dream of cancer biology is to find small molecule drug compounds to restore the activity of p53,» Amaro says.

Its analgesic effect stems from the compound's ability to inhibit the production of cytokines and chemokines, which are small signaling molecules that attract inflammatory macrophages to the nerve cells.

«One of our experiments showed that bypassing Lin28a and directly activating mitochondrial metabolism with a small - molecule compound also had the effect of enhancing wound healing, suggesting that it could be possible to use drugs to promote tissue repair in humans.»

One of the small - molecule compounds the scientists were testing as an ethA booster, SMARt - 420, surprisingly increased ethA2 activity, making the prodrug of ethionamide a bacteria killer.

The researchers also tested a small molecule splicing modulator compound derived from a natural product and developed in the lab of Michael Burkart, PhD, professor in the Department of Chemistry and Biochemistry at UC San Diego.

Scientists for decades have applied similar «phenotypic selection» methods to libraries of standard small - molecule compounds.

Towards reducing the global burden of malaria and other neglected diseases, millions of compounds were screened, prioritized and assembled by the WHO - supported Medicines for Malaria Venture (MMV) as the MMV «Malaria Box» collection of 400 chemically diverse small molecules.

The attraction of large - scale compound screening for life science researchers lies mainly in the technical challenge of assay design and the use of small - molecule effectors for hypothesis - driven research.

With that goal in mind, Xue and his team joined forces with Chen Zhao, MD, PhD, UI assistant professor of pathology, and used their understanding of CML genetics to look for small molecules or drug compounds that might be able to eradicate the leukemia stem cells.

The MSC is a core facility providing the use of high throughput screening technology (HTS), as well as expertise and reagents, necessary for the screening of the library of small molecules for biologically active compounds in a variety of readout systems.

These small molecules, and their improved chemical daughter compounds in the future, will help discovery of novel epitranscriptomic mechanisms regulating physiological and pathophysiological processes.

For these purpose, we explore and validate the use of cell progenies derived from pluripotent stem cells to produce disease models in a dish, to screen for compounds (small molecules, biologicals, etc).

The course gives a broad introduction to high throughput screening (HTS) that is technique used to identify biologically active small organic molecules through screening of compound libraries with the help of robust test systems and advanced instrumentation.

Identification of small molecule inhibitors of Cisplatin - induced hair cell death: results of a 10,000 compound screen in the zebrafish lateral line.

Instead of using a set of genes to induce the cellular transformation, he relies primarily on pharmaceutical compounds, known as «small molecules.»

Currently, Everon is optimizing several lead compounds: small molecules and biologics that have already demonstrated a rejuvenation effect in aging animals, as measured by a lowered mouse FI (similar FI has recently been accepted by FDA as a measure of aging in the ongoing Metformin human trial).

Previous searches for organic molecules in the LMC detected small amounts of methanol, the parent molecule of the two newly - discovered compounds.

Proving their hunch, the researchers found ascarosides in the secretions of every nematode they examined, and a few subsequent experiments showed that the small compounds also acted as signaling molecules in the species» they investigated.

He went on to a postdoctoral position with Dr. Iwao Ojima evaluating anti-tubercular compound series that inhibit the cell division protein FtsZ and screening computationally designed small molecule inhibitors of Botulinum neurotoxin.

An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.

Then for postdoctoral research I moved to Yale University, where I worked in a lab that looked at all kinds of different disease areas using the approaches of a field called chemical biology, which is using small molecules — chemicals — to probe biological systems in the hopes of developing compounds that could be new drugs.

Shi, Y.; Desponts, C.; Do, J. T.; Hahm, H. S.; Scholer, H. R.; Ding, S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small - molecule compounds.

This is basically tweaking the molecules: making small chemical changes to the compound in hopes of finding something that could block the growth of blood vessel cells initially in the culture dish without having toxic effects on other cell types.

But for people with type 2 or type 3 SMA, «the reality is that any sort of treatment would be a blessing,» says Jill Jarecki, research director of Families of SMA who, in a previous job, led the small - molecule screening effort that yielded RG3039, the Repligen compound.

The Alzheimer's Innovation Award will help advance particularly critical components of Mucke's ongoing drug discovery program to identify and optimize small molecule compounds that potently and safely reduce tau levels in the brain.

Small molecule a low molecular weight (usually less than 500 Daltons) organic compound that can bind to and alter the activity or function of proteins, nucleic acids, or polysaccharides.

Then the wells were exposed to a library of small - molecule compounds.

Most vegetables contain, in small doses, essential fatty acids, which are the main compounds of the anti-inflammatory molecules in our body.

The membrane of the small intestine allows only very small nutrients and fats, proteins and starches which are all broken down to very small particles to enter into the bloodstream, while the larger molecules and many different types of toxic compounds are kept out.

A molecule is a term used to describe the smallest form of a compound, not an element.

Protein is a compound comprised of chains of smaller molecules known as amino acids, and it's the basic building block of your body.

A molecule is the smallest portion of a compound consisting of the elemental structure of the compound.

In the field of life sciences, he has successfully litigated major cases involving recombinant DNA, monoclonal antibodies, fusion proteins, siRNAs, small molecule compounds, drug delivery, molecular diagnostics, research tool patents, and medical devices.