Sentences with phrase «of small molecule drug»

Dr. Ding's work revolves around chemical reprogramming — the use of small molecule drug mixtures to coax fibroblasts into becoming a variety of other cell types.

The initiative will also allow the CMI to foster new partnerships between academia and industry, and utilize the individual strengths that each possess to expedite the early stages of small molecule drug discovery.

But, says Michael Varney, head of the small molecule drug discovery group at Genentech, those hiring trends are about to change: «For us, over the next 3 years, we'll hire more medicinal chemists and more process and scale - up chemists than we will analytical chemists.»

«This can be accomplished because one advantage of these types of small molecule drugs is that they readily cross the blood - brain barrier and actually prefer to act in the brain,» Rissman said.

Small peptides have the benefits of small molecule drugs, like aspirin, and large antibody therapies, like rituximab, with fewer drawbacks.

eFFECTOR is pioneering a new class of small molecule drugs that act by selectively regulating translation, also known as protein synthesis.

It focuses on the development and commercialization of small molecule drugs for the treatment of central nervous system disorders.

ACADIA Pharmaceuticals Inc. is focused on the development and commercialization of small molecule drugs for the treatment of central nervous system disorders.

Not exact matches

SOUTH SAN FRANCISCO, Calif. — February 5, 2018 — FLX Bio, Inc., a biopharmaceutical company focused on the discovery and development of oral small molecule drugs to activate the immune system against cancer, today announced the appointment of senior pharmaceutical research and development executive Michael F. Giordano, M.D., to its Board of Directors.

The new research, published recently as two separate studies in ACS Central Science and the Journal of the American Chemical Society, demonstrates that a new class of drugs called small molecule RNA inhibitors can successfully target and kill specific types of cancer.

In their ACS Central Science study, Disney and his colleagues used DNA sequencing to evaluate thousands of small molecules as potential drug candidates.

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

The pH during one of the reactions was a bit too low, causing the drug to extrude a single small molecule of propionic acid, which transformed it from a powerful narcotic into a poison that laid waste to the brain's dopamine receptors.

The goal of early SMA drug discovery programs has been to identify small molecules that induce the SMN gene to produce sufficient levels of protein to improve motor neuron functioning in affected patients.

Many drugs today are «small molecule» drugs in which molecules of active ingredients easily dissolve and diffuse because they are small enough to cross key membranes in the body.

«We are very excited about the prospect of using these more physiologically relevant cell - based models for gene and small molecule drug discoveries,» says Dr. Andrew Liu, Assistant Professor of Biology at the University of Memphis.

For instance, a team led by Sheng Ding of the Scripps Research Institute in La Jolla is screening for small - molecule drugs that can substitute for the reprogramming genes.

Using computer simulations to predict which drug candidates offer the greatest potential has thus far not been very reliable, because both small drug - like molecules and the amino acids of proteins vary so much in their chemistry.

«The next step is to identify antibodies and small - molecule drugs that can successfully target Helios or genes in the Helios pathway,» says the study's lead author, Hye - Jung Kim, PhD, of Dana - Farber.

«The Holy Grail of small molecule research is to know which protein the drug directly binds to.

3BP, part of a class of compounds known as small molecule drugs, was first studied as an anti-cancer agent more than a decade ago at Johns Hopkins by biochemists Young Hee Ko and Peter Pedersen, together with radiologist Jeff Geschwind.

«Our findings will promote the development of specific small - molecule drugs useful to treat Graves» disease and other dysfunctions of GPHRs.»

«A long - standing dream of cancer biology is to find small molecule drug compounds to restore the activity of p53,» Amaro says.

Initial results were discouraging: attempts to simply replace the protein therapies with small - molecule drugs that hit the same targets largely failed, says Saeed Fatenejad, a rheumatologist at Pfizer who is responsible for clinical development of tasocitinib.

The researchers created a new gel, based on small molecules which self - assemble into nanofibers which could interact with a variety of anti-inflammatory, painkiller drugs, including iburofen and naproxen.

Nanotechnology has unlocked new pathways for targeted drug delivery, including the use of nanocarriers, or capsules, that can transport cargoes of small - molecule therapeutics to specific locations in the body.

Those features present significant challenges in drug discovery, and in fact, DNA - binding proteins traditionally have been considered to be beyond the reach of even small molecule inhibitors.

However, this security system is so effective at protecting the brain that it prevents many life - saving drugs — all but some small molecules — from being able to treat cancer and other diseases of the brain.

The researchers behind the new study, from Winston - Salem State University in the US and Universiti Malaysia Sarawak in Malaysia, have found that adding similar, but smaller polycationic molecules onto a new kind of material called carbon nanodots makes them even better at killing drug - resistant bacteria.

Now a team reports in Nature that the mood - lifting effect may not be caused by the drug itself, but by one of the products formed when the body breaks the drug down into smaller molecules.

By studying the regulation of the clock proteins called Period (PER) and Cryptochrome (CRY)-- proteins that are thought to be involved with metabolism — St. John and Doyle were able to model the mechanisms of two small - molecule drugs — Longdaysin and KL0001 — that regulate the expression of the clock proteins.

Coincidentally, co-author Lawrence Shapiro, PhD, at Columbia, was building a crystal structure of cadherin - 11 and is now working with Byers and Brenner to show how the molecule binds to Celebrex and other small molecule drug cadherin - 11 inhibitors.

«One of our experiments showed that bypassing Lin28a and directly activating mitochondrial metabolism with a small - molecule compound also had the effect of enhancing wound healing, suggesting that it could be possible to use drugs to promote tissue repair in humans.»

• For small - molecule drugs, excretion via the kidneys is the most common path of «decay».

The new drug, a small molecule called anle138b, blocks these pores from moving ions in and out of nerve cells.

An international team of researchers has shown that a new small - molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease.

This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection,» Dr. Oxana Denisova says.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

Small molecule drugs were used to inhibit the function of a cellular pathway associated with protein synthesis.

Small molecule drugs can be screened or designed to increase telomerase activity exclusively within stem cells for disease treatment as well as anti-aging therapies without increasing the risk of cancer.

A small piece (lower left) of a larger drug molecule (top left) is enough to distract bacterial defenses and allow the larger molecule to remain inside the bacterium.

As a postdoctoral researcher at Harvard Medical School, he investigated the use of small - molecule drugs to manipulate signaling pathways to enable otherwise senescent progenitor cells of the cochlea to divide and form new sensory cells.

Basic research on cancer mechanisms has led to over 40 targeted cancer therapies currently on the market, which take the form of monoclonal antibodies, small molecule drugs, and immunotherapies.

The majority of drugs that humans use to treat the variety of ailments we suffer are so - called «small molecules.»

In principle, if further tests bear out the protective effects of the two antibodies, then optimized versions of them, or small - molecule drugs that hit the same target, could be developed as treatments for rhinovirus infections.

A new class of experimental drug - like small molecules is showing great promise in targeting a brain enzyme to prevent early memory loss in Alzheimer's disease, according to Northwestern Medicine ® research.

However, some small molecule drugs can cross this barrier and form the basis of targeted therapies.

Blocking this process with a small - molecule drug prevented the characteristic brain plaques and memory loss in a mouse model of the disease.

This will give way to the development of a drug to be used in gene therapy against neurodegenerative diseases based on small molecules which enhance the expression of the gene and / or the use of fragments of the Klotho protein itself.