Sentences with phrase «of sodium channels»

In a major breakthrough several years ago, two research groups, the Zuker group at Columbia and the Bachmanov group at the Monell Center for Chemical Senses, each got around this problem by finding drugs that could temporarily block a certain type of sodium channel in mice's mouths.

So the team turned to a different type of sodium channel, called NaV1.7.

For example, Gentzsch's team found that VX - 770 can decrease the function of a sodium channel in CF epithelial cells and other cells.

The researchers found that, in mice lacking the fragile X protein, mGluR5 provides a signal to modify a kind of sodium channel so that such channels persistently allow too much sodium to flow into neurons.

«Structure of sodium channels different than previously believed.»

«However, this did not reveal any increased formation of sodium channel proteins, which could have explained the overexcitation of nerve cells.»

Pain signals reach the brain via the activation of sodium channels located in the membranes of nerve cells.

Small changes in the protein sequence of sodium channels of American compared with German cockroaches leave the latter susceptible to a venom that has little effect on the former.

They found that, as with calcium channels, increasing calcium concentrations caused calmodulin to bind within the resemblance element of sodium channels and prevent their opening, just as in calcium channels.

The picture for sodium channels, however, was muddier, with different researchers reporting conflicting findings about whether calmodulin and the resemblance element prevent the opening of sodium channels; perhaps the time capsule was damaged over the millenia or was never there.

Dr Chirgadze added: «Our research has important implications for our understanding of the mechanism of sodium channel behaviour.

One very exciting possibility is that the cross-linking of sodium channel α - subunits by 3 trimers could lead to several sodium channels being functionally connected together.

Miljanich believes that a viable alternative to opioids that could work against all pain syndromes could arrive in the next three to four years, most likely as some sort of sodium channel 1.7 blocker.

Dijkstra's simulations show that a temporary blockage of the sodium channels - this is also done in epilepsy treatment - can have an effect.

Spermine belongs to this group; it is produced in cells and plugs the pores of the sodium channels from within.

This enzyme breaks down the spermine which is important in the control of sodium channels.

At the cellular level, consider the voltage-gated behavior of the sodium channels in a nerve axon or the «negative damping» of hair cells in the cochlea.

Intrigued, the doctor, a geneticist named Geoffrey Woods, eventually discovered two families who carried a genetic mutation that blocked the functioning of sodium channel 1.7.

«Introducing this small sequence resulted in a significantly stronger inhibition of the sodium channel,» says Smith.

Fridman and Guan realized that the pain and «feeling» sensory neurons each contained different kinds of sodium channels and that it may be possible to block one kind of channel and not the others to prevent patients from feeling pain but not other sensations.

New Cambridge research provides fresh and unexpected insight into the structure of sodium channels and, specifically, one of its components — β - subunit molecules — which are responsible for «fine - tuning» the activity of the channel.

One particular type of sodium channel, called the Nav1.7 subtype, is responsible for sensing pain.

They want to find something — an engineered small molecule, antibody or, in King's case, a peptide isolated from venom — that inhibits the functioning of sodium channel 1.7.