The acid pump does something similar, but this time with hydrogen
instead of sodium ions — and with the crucial difference that the acid pump does not generate a current.
Now, Klyachko and Pan-Yue Deng, MD, PhD, an assistant professor of cell biology and physiology, have identified a separate mechanism that also results in neuronal hyperexcitability: an increase in the baseline
flow of sodium ions into neurons.
The scintillations of light that Rennich also saw in his aura, Cutrer says, were most likely a
result of sodium ions flooding and overexciting the visual neurons.
The team will use MRI coils for sodium imaging, these are the receivers of radiofrequency signals in the MRI scanner specifically tuned to the resonant
frequency of sodium ions.
When bulky amino acids are introduced at these positions, the channel width no longer corresponds to the
size of sodium ions, and instead cesium ions are transported.
This finding will contribute to advancing the
commercialization of sodium ion batteries (SIBs) and reducing the production cost of any electronic products with batteries.
His training is in MR physics and his PhD thesis is entitled «Three Dimensional Nuclear Magnetic Resonance Spectroscopic
Imaging of Sodium Ions Using Stochastic Excitation and Oscillating Gradients.»
According to a research team led by Thomas Hund, the key may reside in voltage-gated sodium channels, nanoscopic pores that control the flow
of sodium ions across the heart cell membrane.
The work will involve scanning healthy volunteers, and combining conventional Proton MRI to track water in the body with Sodium MRI to analyse the concentration and
flow of sodium ions.