Sentences with phrase «of steatosis»

At the University Children's Hospital Zurich, researchers from the University of Zurich have identified a signaling pathway in liver cells that may contribute to the development of steatosis.

Not exact matches

Non-alcoholic fatty liver disease (NAFLD) is defined medically as macrovesicular steatosis, or abnormal retention of lipids (fats) sufficient and large enough to distort or replace the nuclei of liver cells among those who consume less than 20 grams -LRB-.7 ounces) of alcohol per day.

«Targeting the drivers of aging and senescent cells may be a novel therapeutic strategy to reduce hepatic steatosis and liver fibrosis in ALD patients,» commented co-author Gianfranco Alpini, PhD, Distinguished Professor in the Department of Medical Physiology at Texas A&M College of Medicine, Senior Research Scientist at Central Texas Veterans Health Care System, and Director of the BSW DDRC.

Post-transplant steatosis was not associated with worse patient survival within several years, but the long - term survival of patients with significant steatosis tended to be worse.

When the investigators looked at patients» pre-transplant characteristics, they found that high body mass index and cirrhosis caused by alcohol consumption were linked with an increased risk of developing steatosis.

Hepatic steatosis is defined as the excessive accumulation of fat in the liver and it is the key characteristic of non-alcoholic fatty liver disease (NAFLD).

«Alcoholic liver disease is a spectrum of conditions that range from hepatic steatosis, which is fat deposition in the liver and it is reversible with sobriety, to alcoholic hepatitis which is a more severe condition characterized by extensive and severe inflammation in the liver and often requires hospitalization,» explained Valentina Medici, associate professor of internal medicine at UC Davis Health System as well as corresponding author for the study.

(Left) AIM is taken up into healthy liver cells, where it inhibits lipid storage and prevents steatosis, an illness caused by the buildup of excess lipid inside cells.

«In our study, we were able to demonstrate in mouse models that Fas is activated within the scope of obesity and can therefore lead to the development of liver steatosis,» says Prof. Dr. med.

«Conversely, our study shows that an increased Fas content in the liver can lead to liver steatosis and insulin resistance, even in case of a normal body weight,» Konrad explains.

Worldwide, about 25 to 30 percent of all adults and increasingly children are affected by such steatosis — becoming the most frequent liver disease in recent years.

It enters into normal hepatocytes to keep them skinny, which prevents the buildup of fat inside cells seen in steatosis, whereas it accumulates on the surface of HCC cells to kill them,» says Professor Miyazaki.

Fatty liver disease results from excess accumulation of fat in the liver (hepatic steatosis), leading to inflammation and damage to the liver.

«Regardless of the mechanisms involved, the clinical implications are of critical importance since patients at cardiovascular risk presenting with one or more metabolic syndrome characteristics are at even greater risk if they have steatosis,» noted Dr. Pais.

With recent developments in contrast agents and pulse sequences, some state - of - the - art techniques greatly improve the MR image quality by overcoming the time and spatial resolution limitations and have been used for noninvasive evaluation of hepatic steatosis and vascular and biliary anatomy.

Also known as hepatic steatosis, the research shows that brain ER stress can cause the disease independent of changes in body weight, food intake, and other factors.

Staining of mouse liver sections showing steatosis of the liver (fatty liver), with accumulation of fat, lipid droplets (in red), within cells.

One third of these mice developed severe hepatic steatosis (infiltration of liver cells with fat), neutrophil infiltration, and necrosis, similar to that seen in patients with alcoholic hepatitis.

In the same issue of The American Journal of Pathology, another team of investigators from the University of Kansas Medical Center, led by Dr. Wen - Xing Ding, PhD, Department of Pharmacology, Toxicology, and Therapeutics, also report that FOXO3 protects against acute ethanol - induced steatosis and liver injury.

Hepatic Overexpression of Hormone - sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids, and Ameliorates Steatosis.

Intracellular cholesterol transporters and modulation of hepatic lipid metabolism: Implications for diabetic dyslipidaemia and steatosis.

When this swelling occurs in the liver, the primary target of HCV, it can result in an overall fattening of the organ (called steatosis), leading years later to cirrhosis and liver failure.

Importantly, when treated with steatosis - inducing MCD - media, enhanced hiPS - HEP cells show elevated expression of TNFα mRNA (Figure 6, Panel B).

Hepatic steatosis is defined as the excessive accumulation of fat in the liver and it is the key characteristic of non-alcoholic fatty liver disease.

Enhanced hiPS - HEP cells accumulate triglycerides in lipid droplets and show and elevated level of TNFα mRNA when exposed to steatosis - inducing media.

NAFLD is an imbalance between the uptake and removal of lipids in hepatocytes, which leads to abnormal triglyceride accumulation, or steatosis.

Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high - fat - fed mice.

One in vitro NASH model uses a steatosis - inducing medium [8] to induce expression of TNFα, a marker of inflammation and fibrosis — like the physiologic response to steatosis in progressing NAFLD.

Most obese adults have hepatic steatosis and at least one - third of these individuals will eventually develop worsening NAFLD (1, 3).

When both CD and MCD diets were fed to rats for 7 weeks, the MCD diet group had higher scores of liver inflammation and steatosis than the CD group.

Accelerated weight gain on HFD, incident hepatic steatosis, and hyperinsulinemia of XX animals mainly depended on the amount the X chromosomes.

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity.

NAFLD encompasses a spectrum of disease states, from steatosis (fatty liver) to non-alcoholic steatohepatitis (also called NASH; steatosis with inflammatory changes) followed by progression to fibrosis and cirrhosis and hepatocellular carcinoma (27).

The mechanism for steatosis includes impaired VLDL secretion due to lack of phosphatidyl choline synthesis (11).

Gender difference in hepatic steatosis index and lipid accumulation product ability to predict incident metabolic syndrome in the historical cohort of the Brisighella Heart study

May contribute to the development of diet - induced obesity and several obesity - associated features, such as dyslipidemia and liver steatosis, regulating peripheral lipogenesis, energy expenditure and feeding behavior.

ApoC - III ASO does not induce liver steatosis or production of ketone bodies.

A reduction in TG levels also did not cause hepatic steatosis (Figure 3, A and B) or increase the production of ketone bodies (Figure 3C), and at most had only a modest effect on circulating nonesterified free fatty acid (NEFA) levels (Figure 3D).

The results were that the mice were protected against hyperinsulinemia, obesity, hepatis steatosis, various organ inflammations and had their motor coordination increased, despite consuming the same amount of calories in comparison to the control group of mice that were allowed to consume their food whenever they preferred throughout the day.

Amla prevents fructose - induced hepatic steatosis in ovariectomized rats: role of liver FXR and LXRα.

In steatosis, the milder — and reversible — form, the deposits of fat haven't yet caused inflammation or tissue damage.

In another eye - opening study published in The Journal of Nutritional Biochemistry, researchers discovered that ALA can actually prevent non-alcoholic steatosis brought on by excessive intake of fats.

[A] deficit of GnT - 4a glycosyltransferase expression in beta cells... produced signs of metabolic disease, including hyperglycemia, impaired glucose tolerance, hyperinsulinemia, hepatic steatosis and diminished insulin action in muscle and adipose tissues.

Here, we hypothesized that cyanidin 3 - glucoside (C3G), a typical anthocyanin reported to possess potent anti-inflammatory properties, would ameliorate obesity - associated inflammation and metabolic disorders, such as insulin resistance and hepatic steatosis in mouse models of diabesity.

Ziamajidi N (2013) We evaluated the effects of chicory seed extract on hepatic steatosis caused by elary and late stage diabetes in rats (in vivo) and induced... https://www.ncbi.nlm.nih.gov/pubmed/23603006

Hepatic steatosis is the earliest stage of NAFLD, and it affects about 25 % of people in Western countries.

[16] The classical effect of prolonged use both in adult and paediatric population is steatosis.

Inadequate dietary intake of methyl groups leads to hypomethylation in many important pathways, including 1) disturbed hepatic protein (methionine) metabolism as determined by elevated plasma homocysteine concentrations and decreased S - adenosylmethionine concentrations, and 2) inadequate hepatic fat metabolism, which leads to steatosis (fatty accumulation) and subsequent plasma dyslipidemia.

The alcoholic fatty liver, also called steatosis, is the earliest stage and most common of alcoholic liver diseases.

Hepatic fructose metabolisum leads to all the manisfestations of the Metabolic Syndrome: hypertension, de novo lipogenesis, dyslipidemia, and hepatic steatosis, inflammation, hepatic insulin resistance, obesity, CNS leptin resistance promoting continuous consumption.