Potential scientific questions from this research relate to the origin and function
of stem cell clones and to whether they could be used to predict future outcomes.
Not exact matches
Doesn't the work
of some humans on
cloning and
stem cell, demonstrates that it can be done?
Benedict argued that non-conjugal reproduction such as in vitro fertilization had created «new problems» ¯ the freezing
of human embryos, for instance, and the selective abortion
of medically implanted embryos, together with pre-implantation diagnosis, embryonic
stem -
cell research, and attempts at human
cloning.
No embryo has been generated, no organism «
cloned» if ANT - OAR succeeds in its goal
of producing nothing other than pluripotent
stem cells.
research; since most
of the reports have concentrated on justifying the creation
of cloned human embryos for research into and treatment
of neurodegenerative diseases such as Parkinson's, «
stem -
cells» has become synonymous with «embryonic
stem -
cells» in the public imagination.
If ESCR using «excess» embryos from IVE» continues, the next step will likely be the pursuit
of such «therapeutic»
cloning — the creation
of embryos through somatic
cell nuclear transfer (SCNT) to provide individually tailored
stem cell therapies.
Proponents
of human
cloning assert that this is the only method
of producing pluripotent
stem cells with the same genetic make - up as adult patients.
Human
cloning has been proposed as a means
of generating human embryos that can be destroyed to obtain embryonic
stem cells.
During
cloning, the adult nucleus is converted to a totipotent state that will then proceed through a clear progression
of developmental steps to yield pluripotent
stem cells at a later time.
In our day it has been thrust into the realm
of immediate urgency by advances in embryonic
stem cell and
cloning technologies.
The increasing use
of in - vitro - fertilisation techniques, and the emergence
of new possibilities involving human
cloning, mixing
of human and animal genetic elements, and the use
of embryonic
stem cells for research, among other things, brought the need for further teaching.
And again, this «victory» wasn't rooted in an honest presentation and discussion
of the issues; rather, it was the result
of voter uncertainty about what the amendment entailed, how it defined
cloning, and fear that, if it didn't pass, Missourians wouldn't have access to future
stem -
cell cures.
There are hopes in the medical community that
stem cell research and therapeutic
cloning will facilitate organ
cloning and enable the replacement
of damaged
cells with healthy ones for sufferers
of degenerative diseases.
«It gave critics plenty
of ammunition to insist that if
stem -
cell research was funded, human reproductive
cloning would be funded too,» says Caplan.
(A successful derivation
of stem cells from a
cloned human embryo was not reported until October 2011, and these
stem cells had three sets
of chromosomes rather than two.)
The ethical issues arising from genetically modified crops,
stem cells, or mammalian
cloning have received a great deal
of scrutiny by the media, and the resulting debate is far from settled.
To solve this, West proposed «therapeutic
cloning» — taking the nucleus out
of a patient's
cell, transferring it into an egg
cell to create a
cloned embryo, then using that embryo to derive patient - matched
stem -
cell lines.
Lee and
stem cell researcher Woo Suk Hwang were part
of a team that created the first
cloned dog, Snuppy, in 2005.
Fraudulent
cloned cells were likely the first example
of a human egg turned directly into
stem cells
In humans, the goal
of SCNT is «nonreproductive
cloning» — making embryos, then removing
stem cells from the embryo and cultivating them to grow into tissues that could cure diseases, replace organs and heal injuries.
What do you think resonates in the minds
of the general public when a scientist says he wants to
clone stem cells?
«Dermal papilla
cells give rise to hair follicles, and the notion
of cloning hair follicles using inductive dermal papilla
cells has been around for 40 years or so,» said co-study leader Colin Jahoda, PhD, professor
of stem cell sciences at Durham University, England, and co-director of North East England Stem Cell Institute, who is one of the early founders of the fi
stem cell sciences at Durham University, England, and co-director of North East England Stem Cell Institute, who is one of the early founders of the fi
cell sciences at Durham University, England, and co-director
of North East England
Stem Cell Institute, who is one of the early founders of the fi
Stem Cell Institute, who is one of the early founders of the fi
Cell Institute, who is one
of the early founders
of the field.
But like the medieval alchemists, today's
cloning and
stem cell biologists are working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the nucleus is still a mystery, and scientists have a lot to learn before they can direct a
cell's differentiation as smoothly as nature's program
of development does every time fertilized egg gives rise to the multiple
cell types that make up a live baby.
The Dolly experiment [which yielded the first
cloned adult mammal, Dolly the sheep, in 1996] prompted people to find ways
of taking specialized
cells and transforming them into pluripotent, undifferentiated
stem cells.
Stem cells harvested from embryos rather than adults remain the most powerful for
cloning and other purposes; Yang's team showed that
cloning from such
cells succeeded in 49 percent
of attempts and led to 18 mouse pups.
The completion
of the Human Genome Project and recent advances in
cloning,
stem cells, and other fields have emboldened some scientists to predict that we will soon conquer not only disease but aging itself.
The council, tasked with advising the president on such hot - button issues as
stem cell research and
cloning, has sometimes been dismissed as a vehicle for the right wing
of the Republican Party.
Stem cell researchers call them «a major step in the right direction,» although some were disappointed that NIH didn't open the door to the use
of embryos created for research purposes — including through somatic
cell nuclear transfer (
cloning) and parthenogenesis (from an unfertilized egg).
The results help fill in the scientific puzzle kicked off by Dolly's
cloning, which proved that mammalian egg
cells were capable
of dissolving the genetic roadblocks that limit the potential
of most adult
cells to give rise to only a single type
of tissue — that
of the organ from which they hail — whereas embryonic
stem cells have the potential to become virtually any kind
of body tissue.
Eggan has also been itching to use
cloning technology to create embryonic
stem cells that could be used to model the development
of various diseases, especially diabetes and ALS.
British newspapers reported this weekend that Ian Wilmut, the University
of Edinburgh biologist who led the team that in 1997
cloned Dolly the sheep, is getting out
of the
cloning business in light
of the new findings, which seem to offer researchers a likely new source
of stem cell lines for basic research that could one day lead to new treatments and perhaps cures for spinal injuries, diabetes and debilitating disorders such as multiple sclerosis and Parkinson's disease.
Totipotent
cells are the most versatile
of all
stem cells; a single one can develop into an embryo with a placenta, and hence give rise to a fully formed animal — in other words, a
clone.
Paying for human eggs, many bioethicists argue, commodifies a human resource; Sandel, for example, a proponent
of both research
cloning and embryonic
stem cell research, opposes the idea
of financial inducement for what he calls «human reproductive capacity.»
The finding potentially paves the way for scores
of labs to generate new
stem cell lines without
cloned embryos, which had long been considered the only realistic way
of making human
stem cells in the short run.
THE world's first
cloned human embryonic
stem cells (hESCs) are here, but they can't yet be used to grow tissues for transplant because they have an extra set
of chromosomes.
«Genetically, this type
of clone is still a member
of our species,» says David Prentice, a cellular biologist at Indiana State University and cofounder
of Do No Harm, a group
of scientists favoring alternatives to embryonic
stem cell research.
In a 2009 study, University
of Georgia at Athens
cloning expert Steve Stice created 29 chimeric piglets by injecting pluripotent
stem cells into pig embryos before implanting them into a surrogate womb.
Researchers realized that they could cut open the top
of the trunks
of their highest - yielding trees, extract
stem cells and grow up
clones by the thousands in lab dishes.
Twenty percent
of the
cells cloned in this way grew into early embryos, called blastocysts, and 5 percent
of them yielded embryonic
stem cells, which is comparable with results obtained from unfertilized eggs.
Yet 30 %
of American voters describe themselves as evangelicals, and the voices
of this massive segment deserve to be heard, according to panel speaker James Childress, formerly
of President Bill Clinton's National Bioethics Advisory Commission, which informed the president on
stem cell research,
cloning, and human subjects research.
Schatten, who was part
of Hwang's team, says that the
cloning of dogs is a step towards the
cloning of canine
stem cells.
The creator
of Dolly the sheep has ended his focus on somatic
cell nuclear transfer, or
cloning, in favor
of another approach to create
stem cells
Holstege says the other remarkable finding was that the mutations within the blood
cells were harmless — all resulted from mistaken replication
of DNA during van Andel - Schipper's life as the «mother» blood
stem cells multiplied to provide
clones from which blood was repeatedly replenished.
Stem cell research and human
cloning are legitimate topics
of debate.
Hwang and his team harvested
stem cells — the self - renewing progenitors
of all
cells in the body — from
cloned early - stage embryos made by slipping the nucleus
of a skin
cell into a nucleus - free egg.
But embryonic
clones, the source
of an endless supply
of stem cells imprinted with one's personal DNA, could alter the equation in favor
of the patient and augur a paradigm shift in medicine on par with the changes brought about by antibiotics and vaccines.
The
stem cells produced through this therapeutic
cloning would, like other embryonic
stem cells, be capable
of developing into many
cell types and serve as a repair system for whatever part
of the body required replenishment at the time.
In the future, genomic screening at diagnosis should allow care providers to choose the best treatment option or monitor for the emergence
of clone stem cells.
By May 2005 they had used
cloning techniques to create 11
stem cell lines, each one the perfect genetic match
of a different patient, another first.
Blackburn, a
cell biologist at the University
of California at San Francisco, charges she was released for speaking out in favor
of therapeutic
cloning and against federal funding restrictions on
stem cell research.