«We found that mitochondria communicate changes in cellular organization to initiate a specific metabolic reconfiguration that supports primitive hMSC properties,» said Dr. Teng Ma, senior author
of the STEM CELLS study..
I know of a couple
of stem cell studies going on at universities in the USA, but sadly I do not know of any in the UK.
Not exact matches
Tony co-founded the UW Institute for
Stem Cell and Regenerative Medicine and chaired the Molecular and Cellular Hematology
Study Section for the National Institutes
of Health.
However, embryonic
stem cells remain the «gold standard,» and
studies of all types
of stem cells should continue in parallel for the foreseeable future.»
Cauliflower is full
of sulfur compounds called glucosinolates such as the powerful sulforaphane and isothiocyanates which have been
studied to be very effective for phase II liver detoxification and as cancer
stem cell neutralizing agents.
Studies have shown that these cancer - fighting compounds and enzymes found in broccoli and other cruciferous vegetables may actually prevent the relapse
of certain cancers by killing cancer
stem cells.
In 2010, researchers from the University
of Michigan Comprehensive Cancer Center published a
study in the journal Clinical Cancer Research showing that sulforaphane had the ability to kill breast cancer
stem cells in mice and in lab cultures, and it also prevented the growth
of new tumor
cells.
«We have confirmed what earlier
studies indicated, and gained new knowledge about molecular characteristics
of these neural
stem cells,» says Milos Pekny, professor at the Institute
of Neuroscience and Physiology.
In a group
of patients who underwent surgery for epilepsy, over half had
stem cells where healthy individuals do not have them, according to a
study from Sahlgrenska Academy.
«This model could have far - reaching implications to advance the understanding and treatment
of neurological disorders,» said Svendsen, senior author
of the
Cell Stem Cell study.
Although liver
cells created from induced pluripotent
stem cells reflect the defects
of their source, they may offer a new tool to
study inherited disorders
Speeches came from a variety
of speakers, including a science broadcaster and writer, a Pakistani - born Canadian Muslim who works in
STEM, a Pakistani - born professor who
studies cell biology and anatomy; and, an emergency room physician who helped start the process to phase out coal - fueled power plants by 2030 in Alberta.
The
study also found that in addition to its role in determining the sex
of somatic
cells, Sxl regulation by m6A is required to initiate germline
stem cell differentiation for developing eggs.
«The hope is that ZPF217 could be used to maintain supplies
of therapeutic
stem cells,» said lead
study author Martin Walsh, PhD, Associate Professor
of Pediatrics, Structural and Chemical Biology, and Genetics and Genomic Sciences
of the Icahn School
of Medicine at Mount Sinai.
Cancer
cells which arise due to genetic mutations are just such
cells, and there are
studies which suggest that microchimeric
cells may stimulate the immune system to
stem the growth
of tumors.
«Our research is the first to
study Zika infection in a mouse model that transmits the virus in a way similar to humans,» explains Alysson R. Muotri, Ph.D., professor and director
of the
Stem Cell Program at UC San Diego and co-senior author
of the
study.
In a groundbreaking
study that provides scientists with a critical new understanding
of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the emb
stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the emb
cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center
of Regenerative Medicine and
Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the emb
Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the emb
Cell Research led by Dr. Kathrin Plath, professor
of biological chemistry, have established a first -
of - its - kind methodology that defines the unique stages by which specialized
cells are reprogrammed into
stem cells that resemble those found in the emb
stem cells that resemble those found in the embryo.
«This new
study uncovers for the first time the dynamic
of stem cells during wound healing and identifies new molecular players associated with skin regeneration.
The results
of the
study are published in the academic journal
Cell Stem Cell.
The
study results were found using mouse embryonic
stem cells, which are good
cell models for the
study of processes seen in human
stem cells.
«It was particularly exciting to observe that the repair
of the skin epidermis involves the activation
of very different
stem cells that react the same way to the emergency situation
of the wound and have the power to completely restore the damaged tissue», comments Mariaceleste Aragona, the first author
of the
study.
«The genetic correction doesn't increase the number
of genetic anomalies that you can find in iPS
cells,» says Ludovic Vallier, a
stem -
cell biologist at the University
of Cambridge, UK, and one
of the
study's co-authors.
This may be one
of the most important facets
of studying regeneration in these animals because they provide a completely different approach to tissue regeneration than that offered by
stem cells.
«I think this is the best option we have ever had,» says Renee Reijo Pera, director
of Stanford University's Center for Human Embryonic
Stem Cell Research and Education in California, who wasn't involved in the
study.
Now, in a new
study published today, Sept. 8, in the Proceedings
of the National Academy
of Sciences, a team
of researchers from the University
of Wisconsin - Madison has added a new wrinkle to the
cell differentiation equation, showing that the stiffness
of the surfaces on which
stem cells are grown can exert a profound influence on
cell fate.
His research group now wants to
study if and how
stem cells are able to modulate the activity
of Drosha in order to satisfy demand.
He says the structure could also offer a new way
of studying blood
stem cells and how blood disorders arise.
Some
of the researchers at the centre will
study the differentiation
of stem cells into other
cell types, one group by using human embryonic
stem cell biology and another by
studying early embryo development.
Adding
stem cells from human bone marrow to a broken diabetic bone enhances the repair process, increasing the strength
of the newly formed bone, according to a laboratory - based
study presented at the European Congress
of Endocrinology in Dublin.
For example, animal
studies have shown that neurons derived in the lab from human embryonic
stem cells improve Parkinson's symptoms; however, any residual
stem cells associated with those neurons could form masses
of unwanted
cells.
In a
study in the current issue
of the Journal
of Neuromuscular Diseases, researchers treated these
stem cells with leukemia inhibitory factor (LIF), which effectively maintained the undifferentiated state
of the satellite
cells and enhanced their transplantation efficiency.
We believe that they will also lead to the development
of a whole new range
of therapies for neurodegenerative diseases
of the central nervous system,» explains corresponding author
of the
study Jihwan Song, professor and director
of Neural Regeneration and Therapy Group at the CHA
Stem Cell Institute
of CHA University.
The authors
of the
study say that improvements in management, multi-drug chemotherapy, immunotherapies,
stem cell transplants, radiotherapy and treatments that have less toxic side - effects have all contributed to the improvement in survival from leukemia.
The
study «provided the surprising result that one new therapy currently being explored to lower insulin resistance promotes, rather than decreases, the formation
of bone in mice,» says Darwin Prockop, a
stem cell researcher at Texas A&M College
of Medicine in Temple, who was not involved in the work.
According to Izpisúa Belmonte, who is also a professor at the gene expression laboratories
of the Salk Institute for Biological
Studies in San Diego, California, CMRB aims to become «a research centre
of excellence in south Europe in the line
of world - recognized institutions such as the Salk or the Whitehead institutes, where both pre - and postdoctoral researchers receive multidisciplinary training
of the highest quality» in
stem cell biology and
cell regeneration.
A new
study has found that
stem cell therapy can reduce lung inflammation in an animal model
of chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
Several
studies have used
cell - surface markers — proteins found on the outer membranes
of tumor
cells — to identify glioblastoma
stem cells; but the specific markers used have been controversial and can not reflect molecular processes going on within tumor
cells.
A
study analyzing brain tumor genomics on a single -
cell level has found evidence that cancer
stem cells fuel the growth
of oligodendrogliomas, a slow - growing but incurable form
of brain cancer.
Published in Molecular Neurobiology, the
study led by Dr Elodie Siney under the supervision
of Dr Sandrine Willaime - Morawek, Lecturer in
Stem Cells and Brain Repair at the University, analysed how enzymes called ADAMs affect the movement and function of the human tumor c
Cells and Brain Repair at the University, analysed how enzymes called ADAMs affect the movement and function
of the human tumor
cellscells.
Another problem is that in its July 2009 Guidelines on Human
Stem Cell Research, NIH spelled out specific requirements about embryo donation for newly derived lines, says Pilar Ossorio, a legal scholar who
studies research ethics at the University
of Wisconsin Law School.
An update search enlarged the pool
of study data, but did not change the content
of the conclusion
of the benefit assessment
of stem cell transplantation (SCT) for multiple myeloma conducted in 2012.
Previous
studies have examined cancer
stem cells (CSCs)-- small populations
of cells within a tumor that are resistant to chemotherapy.
Studying mice with injuries to the lining
of the stomach, the researchers blocked the animals» ability to call on
stem cells for help in the stomach.
«The potential advantage
of stem cells,» says Eugene Redmond, a professor
of neurosurgery at the Yale University School
of Medicine and the lead author
of that
study, «is that they still have the potential to migrate and position themselves in appropriate places depending on what signals are there [in the brain].»
«These results provide the basis for the potential implementation
of 5 - LO - inhibitors as
stem cell therapeutic agents for a sustained AML cure, although this must be investigated further in preclinical and clinical
studies in humans,» explains Dr. Ruthardt.
The new rules state that
stem cells can be used if they are part
of a
study approved by the federal government, or if the protocol has been approved by an Institutional Review Board (IRB) that provides ethical review for research involving human volunteers.
And while cytochalasin D might not be the actual agent scientists use to trigger bone formation in the clinic, Rubin's
study shows that triggering actin transport into the nuclei
of cells may be a good way to force mesenchymal
stem cells to become bone
cells.
Shane Mayack was a postdoc in the lab
of Amy Wagers at Harvard University's Joslin Diabetes Center,
studying blood
stem cells.
Pre-clinical
studies have shown it to be effective in eliminating a number
of different kinds
of cancers
cells, including cancer
stem cells from human breast cancer patient biopsies.
«Interestingly, we also found that vitamin C treatment had an effect on leukemic
stem cells that resembled damage to their DNA,» says first
study author Luisa Cimmino, PhD, an assistant professor in the Department
of Pathology at NYU Langone Health.