The Workshop: Current research is showing major breakthroughs in what happens in the brain following trauma, indicating that insight and understanding may have a limited influence on the operation
of subcortical processes and the resolution of trauma.
Current neuroscience research indicates that insight and understanding may have only a limited influence on the operation
of subcortical processes disrupted by traumatic and relational wounds of war.
Studies have shown that cognitive fatigue is due to a failure of the non-motor function of the basal ganglia, a group
of subcortical nuclei in the deep brain.
Here we demonstrate that humor modulates activity in several cortical regions, and we present new evidence that humor engages a network
of subcortical regions including the nucleus accumbens, a key component of the mesolimbic dopaminergic reward system.
«Discovery of the characteristics
of subcortical regions in schizophrenia.»
Contrary to previous assumptions, dopamine helps both strengthen and weaken synapses made by cortical cells onto cells
of the subcortical striatum.
«During the development from childhood to adolescence, the spontaneous activity of cortical regions involved in basic sensory perception decouples from the activity
of subcortical structures relaying sensory information from the sensory organs to the cortex,» explains Keysers.
Both halves are extensions
of subcortical, sensory relay centers; the neocortex or new brain is an outgrowth of the old brain.
Not exact matches
The K - D test, originally developed in the 1980's by optometrists Al King and Steve Devick at the Illinois College
of Optometry, provides objective measures
of many aspects
of brain function, including
subcortical (subconscious) pathways that extend beyond eye movements.
Physiologic studies have demonstrated that, in general, swaddling decreases startling, 301 increases sleep duration, and decreases spontaneous awakenings.310 Swaddling also decreases arousability (ie, increases cortical arousal thresholds) to a nasal pulsatile air - jet stimulus, especially in infants who are easily arousable when not swaddled but less so in infants who have high arousal thresholds when not swaddled.301 One study found decreased arousability in infants at 3 months
of age who were not usually swaddled and then were swaddled but found no effect on arousability in routinely swaddled infants.301 In contrast, another group
of investigators showed decreased arousal thresholds310 and increases in autonomic (
subcortical) responses311 to an auditory stimulus when swaddled.
This is the same
subcortical structure that reacts to fast unconscious assessment
of threats.
Although arduous to collect, these data represent the first report in living humans
of scalp - delivered tDCS voltage measurements across DBS electrodes at the
subcortical level.
If you go into the brain stem or into other
subcortical areas
of the brain, the neurons have no distinguishing features.
«Typically, an overproduction
of axons and synapses can be found during early puberty, followed by rapid pruning during later puberty, indicating that connections and communication between
subcortical and cortical regions are in a highly transitional state during this period.»
The increased interaction between cortical and
subcortical brain regions highlights the central role
of hypersensitivity and other sensory symptoms in defining Autism Spectrum Disorder (ASD).
The grand symphonic piece that is consciousness encompasses the foundational contributions
of the brain stem, forever hitched to the body, and the wider - than - the - sky imagery created in the cooperation
of cerebral cortex and
subcortical structures, all harmoniously stitched together, in ceaseless forward motion, interruptible only by sleep, anesthesia, brain dysfunction, or death.
«We did not find evidence
of genetic overlap between schizophrenia risk and
subcortical volume measures, either at the level
of common variant genetic architecture or for single genetic markers.
They compared and analyzed magnetic resonance imaging (MRI) brain images
of 1,680 healthy individuals and 884 patients with schizophrenia from 11 research institutes participating in Cognitive Genetics Collaborative Research Organization (COCORO), and examined the differences between schizophrenia and healthy controls in the
subcortical regional volumes and their asymmetries.
A new study led by Patrick F. Sullivan, MD, FRANZCP, a researcher and professor at both the University
of North Carolina School
of Medicine and the Karolinska Institutet in Stockholm, Sweden, evaluated the relationship between common genetic variants implicated in schizophrenia and those associated with
subcortical brain volumes.
«No link found between
subcortical brain volumes, genetic risk for schizophrenia: Proof -
of - concept study provides roadmap for future research into possible associations between brain volume measures, known genetic risk factors.»
«It is interesting to consider the evolutionary importance
of the connection between the auditory areas, cortical, and the more primitive system
of emotional evaluation,
subcortical,» says the researcher.
According to Irene Esteban - Cornejo, postdoctoral researcher at the University
of Granada and main author
of this paper, gray matter volume in the cortical and
subcortical regions influenced by physical fitness improves in turn the children's academic performance.
This suggests that functional brain networks are optimized toward processing speed and a high level
of efficient global information integration between cortical and
subcortical regions
of the brain network.
In summary, individual functional brain networks were formed out
of all the cortical and
subcortical brain voxels (∼ 9500 voxels, called nodes) with connections between all functionally linked voxels.
More specifically, the researchers have confirmed that physical fitness in children (especially aerobic capacity and motor ability) is associated with a greater volume
of gray matter in several cortical and
subcortical brain regions.
Imaging studies have shown differences in the frontal cortex and
subcortical structures
of the brain in patients with OCD.
Please see Fig. 3 for presentation
of results that include
subcortical gray matter structures.
Functional MRI
of the immediate impact
of transcranial magnetic stimulation on cortical and
subcortical motor circuits.
Fetal neurosonography and magnetic resonance imaging (MRI) have also showed diffuse calcification in the
subcortical parenchyma and thalamic areas, ventriculomegaly, lissencephaly, and pachygyria (ie, smooth brains with reduced gyral ridges).6 Nevertheless, to our knowledge, a systematic follow - up
of clinical and morphological features
of these cases along with anatomic and pathological descriptions associated with congenital ZIKV infection has not been reported.
Seed - based, resting - state connectivity analysis revealed that the site
of stimulation in both patients was at the core
of a large - scale distributed network linking aMCC to the frontoinsular and frontopolar as well as some
subcortical regions.
«Our findings confirm that
of prior studies showing that these patients tend to have lesions
of the frontal -
subcortical network.
Much
of the literature on maternal behavior has focused on the role
of infant experience and hormones in a canonical
subcortical circuit for maternal motivation and maternal memory.
Gross brain pathology from infants with presumed or laboratory - confirmed ZIKV infection, primarily from neuroimaging, closely resembles neuropathology associated with congenital cytomegalovirus (CMV).48 The most notable difference is the distribution
of intracranial calcifications (ie, typically
subcortical in congenital ZIKV infection and periventricular in CMV).48, 49 Such calcifications are likely dystrophic and related to cell death, either by necrosis, apoptosis, or both.50
Applications in clinical neuroscience have been particularly useful, and have provided insights into systems - level cortical and
subcortical anomalies
of functional connectivity in neurodevelopmental disorders such as attention - deficit / hyperactivity disorder (ADHD, Castellanos and Proal, 2012) and schizophrenia (Yu et al., 2012).
Although many
of the components
of this syndrome, such as cognitive, sensory, and motor disabilities, are shared by other congenital infections, 5 features differentiate CZS from other congenital infections: (1) severe microcephaly with partially collapsed skull; (2) thin cerebral cortices with
subcortical calcifications; (3) macular scarring and focal pigmentary retinal mottling; (4) congenital contractures; and (5) marked early hypertonia with symptoms
of extrapyramidal involvement (Table).
Subcortical connectivity
of the executive - control network mirrors that seen in the monkey (Selemon and Goldman - Rakic, 1988) and does not extend to autonomic control sites.
Another set
of neural structures that may not contribute directly to conscious experience are
subcortical structures such as the basal ganglia.
The infant is a «
subcortical creature... [who] lacks the means for modulation
of behavior which is made possible by the development
of cortical control» (Diamond, Balvin and Diamond, 1963, p. 305).
Subcortical volumetric differences between clinical stages
of young people with affective and psychotic disorders.
These functional maps had large heterogeneous activations, so we parsed them by structure in MNI space to create a final set
of functional masks using FSLView's Harvard - Oxford Cortical and
Subcortical atlases.
A number
of psychologists have described some forms
of love just as you have: like an addiction; there is intense desire to spend time with the object
of our affection, we experience intense cravings, emotional dependence, mood swings, and even loss
of control and compulsive behaviors.1 In one study utilizing fMRI technology (brain imaging),
subcortical reward systems in the brain were activated when adults viewed photographs
of someone who had rejected their love; 2 this part
of the brain is the same area that lights up when people experience intense, romantic love3 and is rich in dopamine, which is a neurotransmitter associated with rewards like pleasure.
The highest levels
of management
of self and emotional regulation are thought to involve at least 5 frontal -
subcortical circuits, or feed - back loops, which exchange information back and forth (Hale and Fiorello, 2004).
Magnetic resonance imaging analysis
of amygdala and other
subcortical brain regions in adolescents with bipolar disorder
The use
of strategies that work directly with
subcortical brain regions and the body can assist children in becoming more resourced to access the aftermath
of chronic early trauma.
Also noteworthy in this context, the prefrontal brain systems that process rewards and support reward - based decision - making undergo a prolonged and vulnerable developmental trajectory, and an impaired capacity
of these prefrontal systems to regulate
subcortical structures (particularly striatal regions
of the basal ganglia) is implicated in risky, impulsive and otherwise disadvantageous decision - making from childhood through later life (for review, Fareri et al.
The table contains significant clusters
of voxels (at least 10 significant voxels) within gyral or
subcortical white - matter tracts on the Tract - Based Spatial Statistics - derived fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) skeletons between groups (CD / CU +, CD / CU - and healthy controls).