Sentences with phrase «of such mutations»

They then mimicked the effects of such mutations in lab dishes by systematically inactivating each of these cancer - associated genes in healthy human cells, creating 625 different perturbations that mirrored distinct genetic mutations seen in real breast and ovarian cancers.

Professor Mathias Uhlen, Director of the Human Protein Atlas consortium and leader of the Pathology Atlas effort says: «This study differs from earlier cancer investigations, since it is not focused on the mutations in cancers, but the downstream effects of such mutations across all protein - coding genes.

The argument against neo-Darwinism begins from the undoubted observation that many features of living beings, like the bacterial flagellum or the human eye, are the result of not one genetic mutation but of a large number of such mutations.

Scientists know that accumulation of somatic DNA mutations is a feature of aging, though little data exists on the role of such mutations in age - associated disorders beyond cancer.

We intend to follow up this work by trying to get yet more detail on the prevalence of such mutations as well as by testing for these events in other tissues; most genetic investigations are performed only in blood, so we may have missed some disease - causing mutations by not testing elsewhere,» Dr Gilissen will conclude.

The National Institutes of Health says that mutations in the BRCA1 and BRCA2 genes tend to increase ovarian cancer risk, but the presence of such a mutation does not guarantee that a cancer will form.

Providing a comprehensive catalogue of such mutations from across an entire population is therefore not just scientifically interesting but also an important contribution to improving rare disease diagnostics.»