Sentences with phrase «of synapse formation»
However, studying the general mechanisms of synapse formation and distribution in dendrites has been challenging due to a lack of reliable methods that trigger and monitor synapse formation.
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«New theory of synapse formation in the brain.»
The vision driving the project is that valuable ideas for the treatment of stroke patients could result from accurate predictions of synapse formation.
Not exact matches
And those mushy, sentimental notions find their articulation in the infants» brains in precise neurochemical reactions: the formation of a synapse, the pruning of a dendrite, the methylation of a DNA sequence.
«Aberrant synapse formation is important in the pathogenesis of schizophrenia and autism,» says Osaka University Professor Toshihide Yamashita, one of the authors of the study.
The genes we detect are involved in the regulation of cell development, and are specifically important in synapse formation, axon guidance and neuronal differentiation.
«This opens the door to follow the natural evolution of synaptic density with normal aging and follow how drugs can alter synapses or synapse formation.»
«Visualization of newly formed synapses with unprecedented resolution: Researchers optimized a spatiotemporally controlled method to induce, visualize synapse formation in cortical neurons.»
In the hippocampus, a major component responsible for memory, neural activity, synapse formation and expression of brain - derived neurotrophic factor (BDNF) were reduced in these mice (Image 2).
«Given that abnormal synapse formation causes various neurodevelopmental diseases such as autism spectrum disorders and epilepsy, understanding activity - dependent mechanisms of initial synapse formation will be important for developing new therapeutic strategies for these conditions,» explained Dr. Kwon.
Astrocytes are responsible, for example, for the energy production of the brain, ion and pH balance, and they regulate synapse formation, the connections between neurons.
It interferes with the production of a protein critical to synapse formation during a brief period in early development when the brain is optimizing its ability to process sensory input.
In summary, our results demonstrate that PKN1 functions as a developmentally active gatekeeper of AKT activity, thereby fine - tuning axonal outgrowth and presynaptic differentiation of Cgcs and subsequently the correct PF - PC synapse formation.
Dr. Parsons has shown that while there is some degree of tonic endocannabinoid formation in the brain, an overt influence of endocannabinoid signaling requires synapse - specific activation of endocannabinoid formation.
Control of axonal branching and synapse formation by focal adhesion kinase.
Antigen - specific blocking of immunological synapse formation using bifunctional peptide, Utilization of I - domain of LFA - 1 to Target Drug and Marker Molecules to Leukocytes.
Indeed, the rapid remodeling of the axon during local morphogenetic events such as axon elongation, branch formation and elimination and synapse consolidation has an important energetic toll.
The hypothesis is that astrocytes play a crucial role in dictating synapse formation and function via the release of specific proteins that determine the type of synapse that will form, and the strength of that synapse.
mTOR - dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.
Farhy - Tselnicker I, van Casteren ACM, Lee A, Chang VT, Radu Aricescu A, Allen NJ (2017) Astrocyte - Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation.
In one study conducted at the New York School of Medicine, researchers were able to observe synapse formation in the brains of genetically engineered mice.
For example, our discovery of HORMAD1 (Fig 2) and HORMAD2, two proteins that preferentially associate with unpaired / unsynapsed meiotic chromosome cores / axes, allowed us to address how progression in meiosis is coordinated with crossover formation, and how meiotic checkpoints / quality control ensure that only those meiocytes progress in meiosis that correctly paired and synapsed their homologous chromosomes.
TKF: You then applied schizophrenia drugs to these not - fully - mature cultured neurons derived from schizophrenic patients and found that some of these drugs reversed the abnormalities in synapse formation you saw.
The following position is available at the Department Experimental Immunology of the Helmholtz Centre for Infection Research (HZI) in Braunschweig: PhD candidate: Control of immunological synapse formation in regulatory T cells.
Ginger significantly increased nerve growth factor (NGF), which stimulates the growth of new neurons, and synaptophysin and PSD - 95, two indicators of higher synapse formation.