Sentences with phrase «of synaptic activity»

«We might have some real insight into the advantages of dampening of synaptic activity that is caused by fasting,» said Haghighi, for example, how fasting can be beneficial for epileptic patients, who can experience reduced seizures when restricting calories.

In this sense, LPA could be a key mediator in these cases of modulation of synaptic activity in learning and memory processes, and this explains the relevance of the work we have carried out,» highlights the professor from the UCA.

Not exact matches

Researchers can identify the parts of the brain responsible for these emotions and measure synaptic activity corresponding to them.

As a result of this synaptic upscaling, the activity of the affected network returned to its starting value after a period of between 24 and 48 hours.

Synaptic plasticity, the ability of neurons to alter the strength of their synaptic connections with activity and experience, is thought to play a critical role in memory Synaptic plasticity, the ability of neurons to alter the strength of their synaptic connections with activity and experience, is thought to play a critical role in memory synaptic connections with activity and experience, is thought to play a critical role in memory storage.

The detectable phosphodiesterase activity was localized in postsynaptic (dendritic) nerve endings, most of it immediately adjacent to the synaptic membrane.

This finding is in accordance with earlier animal model studies, which have shown that physical activity increases the amount of growth factors in the brain and improves synaptic plasticity.

The existence of this enzyme may account for the increased amount of adenosine 3», 5» monophosphate associated with synaptic activity in the ganglion.

They used a somewhat bizarre technique in which two mice were sutured together in such as way that they shared a circulatory system (known as parabiosis), and found old mice joined to their youthful counterparts showed changes in gene activity in a brain region called the hippocampus as well as increased neural connections and enhanced «synaptic plasticity» — a mechanism believed to underlie learning and memory in which the strength of neural connections change in response to experience.

The extracellular space's fluid — a reservoir of ions critical for electrical activity and synaptic transmission — appears as tiny black spaces among white filaments and blobs.

«Our second surprising discovery is that this transport process is dependent on synaptic activity,» says Kiebler: The intron - containing mRNA is transported from one synapse to the next — but will only be released for translation in the vicinity of synapses that are momentarily active.

«This work shows that dendritic spines, which are sub-micrometer compartments within individual neurons, are the prime candidates for the initial tag of transient, millisecond synaptic activity that eventually orchestrates memory traces in the brain lasting tens of years,» said Shahid Khan, senior scientist at the Molecular Biology Consortium at Lawrence Berkeley National Laboratory and a co-author on the PNAS paper.

Hence, synaptic activity stimulates the docking of the mRNA to specific synapses, and its protein product marks «learning» synapses.

Closer inspection of neuronal activity did reveal that reducing BACE1 activity did not completely restore synaptic functions and the researchers do suggest that caution is still warranted as the enzyme does seem to be fundamental for optimal cognitive function.

The work combines remote control of action potential firing and synaptic signaling combined with imaging of activity with genetically encoded calcium and voltage sensors and electrophysiology.

Long - term potentiation (LTP), a phenomenon in which brief repetitive activity causes a long lasting (many weeks) enhancement in the strength of synaptic transmission, is generally accepted to be a key cellular substrate for learning and memory.

Activity - dependent and independent mechanisms regulate synaptic size and strength to ensure a balance between excitation and inhibition of inputs and between input and output.

We are particularly interested in an emotional stress - induced change in endocannabinoid signaling and synaptic transmission and the effects of stress on the activity of a neuronal circuitthat is associated with learning / memory (see J. Neurosci.31: 501, 2011, 29:381, 2009; Nature Neurosci.

Excitation - transcription coupling via CaMK / ERK signaling mediates the coordinate induction of VGLUT2 and Narp triggered by a prolonged increase in glutamatergic synaptic activity.

Advances in optical imaging and optogenetics combined with electrophysiological recordings enable Albeanu and colleagues to monitor and / or alter patterns of activity at unprecedented synaptic and millisecond resolution, in real time, as animals are engaged in various behaviors.

Based upon activity in multiple CNS toxicity assays, we identified an exceptionally potent, orally active, neurotrophic molecule called J147 that facilitates memory in normal rodents, and prevents the loss of synaptic proteins and cognitive decline when administered to three - month - old APP / swePS1ΔE9 mice for seven months [7].

The latter discovered significant alterations in synaptic structure and activity in excitatory neuronal networks of the hippocampus, a region of the brain that plays a major role in cognitive processes.

YanGang Sun, Juan Pita - Almenar, Chia - Shan Wu, John J Renger, Victor N. Uebele, Hui - Chen Lu, Michael Beierlein (2013) «Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons», Journal of Neuroscience 33: 2048 - 59.

Kauwe and others in Haghighi's lab are exploring why such a change in the set point of synaptic transmission occurs so rapidly, and how dampening neuron activity might be beneficial in treating, or even preventing, neurodegenerative diseases.

In 2005, we demonstrated that astrocytes integrate and process synaptic information and confirmed that astrocytes modulate neuronal electrical activity through activation of NMDA receptors (Perea and Araque, J Neurosci, 2005).

According to their paper, the cellular stress and lack of nutrition catalyzed by fasting blocks the synaptic activity of neurons that normally occurs in the brain, which essentially means that the brain slows down.

Increased perfusion to brain tissue, decreased body weight, upregulation of growth factors and improved synaptic plasticity may all be molecular mechanisms underlying the benefits of enrichment and activity therapies.