Sentences with phrase «of synaptic connectivity»

Phencyclidine - Induced Decrease of Synaptic Connectivity via Inhibition of BDNF Secretion in Cultured Cortical Neurons % U http://cercor.oxfordjournals.org/content/early/2012/03/30/cercor.bhs074.short.

Previous work had shown that spines grow when neurons undergo long - term potentiation, a persistent strengthening of synaptic connectivity that happens naturally in the brain but can also be artificially induced through stimulation.

«Some neuropsychiatric disorders, such as schizophrenia and autism, are characterized by the abnormal development of synaptic connectivity in certain key parts of the brain,» explains Schneggenburger.

Not exact matches

Some of the key differences, they note, center around brain development and synaptic connectivity.

«Although the two types of inhibitory neurons are very similar to each other in terms of morphology, synaptic connectivity, and the kinds of small molecules they use for signaling, they're very different in terms of the methylation pattern.

This finding suggests that impaired retrieval of memories, rather than poor storage or encoding, may underlie this prominent symptom of early Alzheimer's disease and points to the synaptic connectivity between memory cells as being crucial for retrieval.

«We have shown for the first time that increasing synaptic connectivity within engram cell circuits can be used to treat memory loss in mouse models of early Alzheimer's disease,» says lead author Dheeraj Roy.

According to Riken, the finding suggests that impaired retrieval of memories, rather than poor storage or encoding, may be behind the hallmark memory loss associated with early Alzheimer's disease, and points to the synaptic connectivity between memory cells as being crucial for the retrieval of memories.

«We have shown for the first time that increasing synaptic connectivity within engram cell circuits can be used to treat memory loss in mouse models of early Alzheimer's disease,» said lead author Dheeraj Roy in a release.

Restricted expression of UNC - 7S from the Punc - 7S promoter allowed us to recognize AVB: B motor neuron gap junctions in live animals and has served as a useful tool for examining changes in synaptic connectivity [29].

«We hope to gain a comprehensive understanding of the connectivity and synaptic plasticity mechanisms underlying higher brain functions,» says neuroscientist Kyungjin Kim, president of the Korea Brain Research Institute.

One final example is the prefrontal cortex, which is thought to play an important role in regulating behavior by suppressing impulses and emotions arising from the amygdala and other parts of the limbic system.50 — 52 In animal studies, exposure to chronic stress or glucocorticoids alters the synaptic connectivity within the prefrontal cortex, 52,53 and this may limit the ability of the prefrontal cortex to (1) suppress the impulsivity and aggression of the limbic system, and (2) execute adaptive responses (rather than maladaptive responses) to stress.54 — 56 Stress - induced changes in brain structure parallel the well - described impact of significant childhood adversity on a variety of brain functions, including the modulation of physiologic responses (hyper - responsive or chronically active stress response), learning (impaired memory), and the regulation of behavior (the ability to execute adaptive vs maladaptive responses to stress).3, 39,57