Glutamate receptors (pink spots) concentrate at sites
of synaptic contact on a hippocampal neuron dendrite.
Inducible expression of a mutated mitochondrial UNG1 DNA repair enzyme in forebrain neurons caused generation of apyrimidinic mDNA and neuronal impairment including reduced size
of synaptic contacts (Mol Cell Mol 2010).
Not exact matches
Shatz hypothesized that MHCI molecules might function as a kind
of «
synaptic glue,» stabilizing
contacts between neurons once appropriate connections had been established.
The number
of neurons in each human brain is on the order
of billions, and the
synaptic contacts that the neurons make among themselves number in the trillions.
Once the elongating fibers have established the appropriate
synaptic contacts with the target cells, the continued survival
of the innervating cells in the ganglion appears to depend on the availability
of NGF.
By the 1980s, it was well established that nerve cells communicate through the process
of chemical
synaptic transmission at specialized
contacts called synapses.
''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (
synaptic contacts), number
of cells (reduction
of neuronal density), composition
of the extracellular matrix (accumulation
of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation
of behavior (cognitive decline).