Sentences with phrase «of synaptic contacts»

Inducible expression of a mutated mitochondrial UNG1 DNA repair enzyme in forebrain neurons caused generation of apyrimidinic mDNA and neuronal impairment including reduced size of synaptic contacts (Mol Cell Mol 2010).

Glutamate receptors (pink spots) concentrate at sites of synaptic contact on a hippocampal neuron dendrite.

Not exact matches

Shatz hypothesized that MHCI molecules might function as a kind of «synaptic glue,» stabilizing contacts between neurons once appropriate connections had been established.

The number of neurons in each human brain is on the order of billions, and the synaptic contacts that the neurons make among themselves number in the trillions.

Once the elongating fibers have established the appropriate synaptic contacts with the target cells, the continued survival of the innervating cells in the ganglion appears to depend on the availability of NGF.

By the 1980s, it was well established that nerve cells communicate through the process of chemical synaptic transmission at specialized contacts called synapses.

''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).