These data suggest that APP / PS1 mutations result in a reduced axonal Vc, potentially disrupting the timing
of synaptic inputs.
Since most neurons receive thousands
of synaptic inputs, the neuronal membrane is a mosaic of specialized microdomains where neurotransmitter receptors cluster in register with the corresponding presynaptic neurotransmitter release sites.
Not exact matches
In the journal Physics
of Life Reviews, Stuart Hameroff and Sir Roger Penrose suggest that quantum vibrational computations in microtubules (components
of a cell's structure) are «orchestrated» by
synaptic inputs and memory, and terminated by «objective reduction».
Current projects include modeling the biophysical mechanisms underlying
synaptic plasticity and learning in dendritic trees, the dynamics
of neuronal networks in the outer plexiform layer
of the retina, and modeling the integration
of multiple
synaptic inputs in muscle fiber.
Previous research by Burger and Stefan Oline — a former Ph.D. candidate at Lehigh, now a postdoctoral fellow at New York University Medical School — demonstrated for the first time that
synaptic inputs — the messages being sent between cells — are distinct across frequencies and that these different impulse patterns are «mapped» onto the cells
of the cochlear nucleus.
In neurons
of DIXDC1 mutant mice (center) the dendrites — neural antennae that receive
input from other brain cells — have fewer
of the dendritic spines (white with red arrows)-- the receiving half
of most
synaptic inputs — compared to dendrites in wild type mice (left).
The researchers developed a
synaptic device that can reconfigure itself based on voltages applied at the
input terminal
of the device.
Activity - dependent and independent mechanisms regulate
synaptic size and strength to ensure a balance between excitation and inhibition
of inputs and between
input and output.
As a rule, EEG signals are generated by synchronized
synaptic input to the dendrites
of neurons arranged in a layer.
Based on evidence from electrophysiological studies showing that both
synaptic plasticity and strength
of inputs to hippocampal region CA1 vary systematically with ongoing theta oscillations (Hyman et al., 2003; Brankack et al., 1993), it has been suggested that the theta rhythm functions to separate periods
of encoding
of current sensory stimuli and retrieval
of episodic memory cued by current stimuli so as to avoid interference that would occur if encoding and retrieval were simultaneous.
This ability
of nerves to modulate their chemical
inputs, known as
synaptic plasticity, is especially high in developing brains but tends to become less intense in adults.
Synaptic reconstruction
of all excitatory
inputs made onto a single cortical pyramidal neuron labeled with sparse in utero electroporation (Unpublished, Dan Iascone)
Synaptic reconstruction
of all excitatory and inhibitory
inputs made onto a single cortical pyramidal neuron labeled with sparse in utero electroporation.
In Vivo Analysis
of Inhibitory
Synaptic Inputs and Rebounds in Deep Cerebellar Nuclear Neurons.
Winfried Denk has devised two experimental innovations
of broad impact to studies
of how individual neurons respond to
synaptic inputs.
The touchpad also needs improvement — it's not just that Razer chose not to go with Precision and instead used
Synaptics (which can be generally passable), but that it's just disappointing for one
of the most - used
input options on a laptop.