Sentences with phrase «of synaptic pruning»

Not exact matches

This period of «synaptic exuberance» can last until age 8, but it's also accompanied by the constant pruning of unused synapses.

The synaptic connections in motor and sensory areas are firmly established and the process of elimination synapses (pruning) in these areas has begun.

Further research showed that fetal mice bred to lack these molecules — like animals lacking MHCI, and like humans with autism or schizophrenia — undergo inadequate synaptic pruning in some parts of their brains.

Pasko Rakic at Yale University and colleagues at the University of Zagreb, Croatia, and the VU University Medical Center in Amsterdam, the Netherlands, have now found that the brains of adults in their 20s are still subject to synaptic pruning.

MRIs of some people with schizophrenia show that parts of their brain are smaller than normal, a feature associated with overactive synaptic pruning in adolescence.

In January 2016, a landmark study in Nature from the Broad Institute in Cambridge, Massachusetts, reported that a set of genes associated with schizophrenia can contribute to synaptic pruning.

In particular, widespread «synaptic pruning» — a sort of scaling down of connectors between neurons — reshapes the brain as a child transitions to adulthood.

A recent study linking schizophrenia and variations of the gene C4 also implicates the pathway involved in synaptic pruning.

What was particularly striking, Stevens notes, is that the researchers also found high expressions of C1q, a protein involved in normal synaptic pruning.

What develops the brain is stimulation — the process of synaptic architecture depends on stimuli — it strengthens the connections needed and prunes those not needed.

Specifically, converging lines of evidence suggest that mechanisms such as oxidative stress and extracellular matrix (ECM) deficit may contribute to the functional impairment of PV neurons, leading to aberrant developmental synaptic pruning of prefrontal cortex neural circuitry and hence a failure in the maintenance of synaptic stability.

In addition to promoting the functional integrity of PV neurons, maturation of ECM may also play an instrumental role in the termination of developmental synaptic pruning; thus, ECM deficit can lead to excessive loss of synapses by prolonging the course of pruning.

The researchers, chiefly from the Broad Institute, Harvard Medical School and Boston Children's Hospital, found that a person's risk of schizophrenia is dramatically increased if they inherit variants of a gene important to «synaptic pruning» — the healthy reduction during adolescence of brain cell connections that are no longer needed.

synaptic pruning The reduction in the number of neurons and synapses that begins in infancy and is mostly complete by early adulthood.

Recently, a research team led by Dr. Cynthia A. Lemere of the Ann Romney Center for Neurologic Diseases at Brigham and Women's Hospital utilized C3 - deficient mice, B6; 129S4 - C3tm1Crr / J (003641) to investigate whether the C3 - mediated synaptic pruning mechanisms at work in the developing brain also contribute to cognitive decline in the aging brain.