Sentences with phrase «of synaptic strength»

«We were able to demonstrate for the first time that these specific cells — a small group of cells in the hippocampus — had undergone this augmentation of synaptic strength,» Tonegawa says.

Repeated applications of serotonin, a facilitating transmitter important in behavioral dishabituation and sensitization, produced growth of the sensory neurons that paralleled the long - term enhancement of synaptic strength.

This action can result in the activation of genes that had been switched off, and could be the cause of the recovery of synaptic strength.

Not exact matches

Synaptic plasticity, the ability of neurons to alter the strength of their synaptic connections with activity and experience, is thought to play a critical role in memory Synaptic plasticity, the ability of neurons to alter the strength of their synaptic connections with activity and experience, is thought to play a critical role in memory synaptic connections with activity and experience, is thought to play a critical role in memory storage.

These properties, which are believed to be important for the induction of long - term changes in synaptic strength, are imparted by asparagine residues in a putative channel - forming segment of the protein, transmembrane 2 (TM2).

The same information can be represented as lines on paper, as electrical charges inside a PC's memory banks or as the strength of the synaptic connections among nerve cells.

Geoff Hinton, a leading neural networking theorist, argues the hardware is useless without the proper «learning algorithm» spelling out which factors change the strength of the synaptic connections and by how much.

They used a somewhat bizarre technique in which two mice were sutured together in such as way that they shared a circulatory system (known as parabiosis), and found old mice joined to their youthful counterparts showed changes in gene activity in a brain region called the hippocampus as well as increased neural connections and enhanced «synaptic plasticity» — a mechanism believed to underlie learning and memory in which the strength of neural connections change in response to experience.

So, rather than the number of AMPA receptors themselves, the abundance of scaffolding proteins appears to determine synaptic strength, effectively allowing AMPA receptors to receive signals from glutamate.

Researchers have observed AMPA traveling from the inside of a neuron to the downstream end of a synapse, but they remain uncertain as to whether the migration into and out of the synapse is the major component in determining synaptic strength.

Moser demonstrated a number of changes in the strength of connections between nerve cells — a phenomenon called synaptic plasticity — in the hippocampus as rats stored information in their long - term memory.

His lab is building detailed computer models of synapses and the networks they sustain in order to determine how they collect firing statistics during wakefulness and sleep and when they change synaptic strengths to reflect the difference.

At the cellular level, learning and memory require continuous readjustment of the strength of synaptic junctions — the functional connections between nerve cells.

«There is mounting evidence that the cellular machinery that controls cell death also controls the strength and number of synaptic connections,» Overstreet - Wadiche said.

They control the strength and duration of the synaptic signal.

It has been known for decades that triggering new protein synthesis is vital to the formation of long - term memories as well as for long - lasting synaptic plasticity — the ability of the neurons to change the collective strength of their connections with other neurons.

Since morphology changes of synapses underlie synaptic plasticity and our learning and memory, this will provide us with many new insights into mechanisms of how neurons store information in their morphology, how it changes synaptic strength and ultimately how it creates new memory.

With the combined use of genetics and pharmacology, the investigators altered the production of proteins controlled by eIF2α in adult mice, essentially converting them into adolescents by making them more susceptible to cocaine - induced changes in synaptic strength and behavior.

«There is mounting evidence that the cellular machinery that controls cell death also controls the strength and number of synaptic connections»

This conclusion is provocative because the dogma has been that a memory is instead stored by synaptic strength,» says Susumu Tonegawa, the Picower Professor of Biology and Neuroscience, the director of the RIKEN - MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, and the study's senior author.

Long - term potentiation (LTP), a phenomenon in which brief repetitive activity causes a long lasting (many weeks) enhancement in the strength of synaptic transmission, is generally accepted to be a key cellular substrate for learning and memory.

Activity - dependent and independent mechanisms regulate synaptic size and strength to ensure a balance between excitation and inhibition of inputs and between input and output.

We use a number of experimental approaches to gain a greater understanding of translational control mechanisms necessary for maintaining long - lasting changes in synaptic strength and memory.

Based on evidence from electrophysiological studies showing that both synaptic plasticity and strength of inputs to hippocampal region CA1 vary systematically with ongoing theta oscillations (Hyman et al., 2003; Brankack et al., 1993), it has been suggested that the theta rhythm functions to separate periods of encoding of current sensory stimuli and retrieval of episodic memory cued by current stimuli so as to avoid interference that would occur if encoding and retrieval were simultaneous.

At the same time, she found that circuits can generate similar neuronal and network outputs from many different configurations of intrinsic neuronal excitability and synaptic strength.