Sentences with phrase «of synaptic vesicles»

Thus, the closed conformation of syntaxin - 1 gates the initiation of the synaptic vesicle fusion reaction, which is then mediated by SNARE - complex / Munc18 -1 assemblies.

Voltage-gated calcium channels can not form properly when cacophony is mutated, preventing fusion of the synaptic vesicle with the plasma membrane and neurotransmitter release.

«It is a sort of shepherding effect by alpha - synuclein that occurs away from the synapse itself, and controls the number of synaptic vesicles used in each transmission,» Fusco said.

Complementary DNA and genomic clones were isolated and sequenced corresponding to rat and human synaptophysin (p38), a major integral membrane protein of synaptic vesicles.

A protein assembly - disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion.

«It was already clear that alpha - synuclein plays some sort of role in regulating the flow of synaptic vesicles at the synapse, but our study presents the mechanism, explaining exactly how it does it,» she said.

Toxins that cleave three different subunits of the vesicular fusion machinery reveal the detailed kinetics of synaptic vesicle release.

Binding of Munc18 - 1 to syntaxin - 1 was impaired in syntaxin - 1BOpen synapses, and the size of the readily releasable vesicle pool was decreased; however, the rate of synaptic vesicle fusion was dramatically enhanced.

After finishing my post-doc, I merged my earlier love of synaptic vesicles with my new knowledge of how to purify and clone membrane proteins, with the ultimate goal of pursuing something entirely new — to identify all the membrane proteins that make up a synaptic vesicle, and to figure out how these vesicle proteins mediate release of neurotransmitters.

Whittaker had introduced me to the subject of synaptic vesicles and neurotransmitter release, but it was Joe Goldstein and Mike Brown who had taught me how to actually approach this subject, and how to study how a synapse works.

In the late 1990s, he and Reinhard Jahn, now at the Max Planck Institute of Biophysical Chemistry, determined the structures of some of the key proteins and complexes involved in the process of synaptic vesicle fusion.

They require a constant supply of energy to mediate the sustained release of the contents of an enormous number of synaptic vesicles, which store the transmitters that convey information between neurons.

Before the fusion of synaptic vesicles with the plasma membrane, a protein complex is thought to form between VAMP — an integral membrane protein of the vesicle — and two proteins associated with the plasma membrane, SNAP - 25 and syntaxin.

This was found to interfere with the same mechanism, essentially by impairing the ability of alpha - synuclein to regulate the flow of synaptic vesicles, and hence compromising the signalling between neurons.

During an action potential, calcium influx into the presynaptic terminal triggers the fusion of synaptic vesicles with the plasma membrane, leading to the release of transmitter through the process of exocytosis.