Sentences with phrase «of synaptophysin»
The structure of synaptophysin suggests that the protein may function as a channel in the synaptic vesicle membrane, with the carboxyl terminus serving as a binding site for cellular factors.
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Complementary DNA and genomic clones were isolated and sequenced corresponding to rat and human synaptophysin (p38), a major integral membrane protein of synaptic vesicles.
The analysis also showed reduced production of two proteins important for neuron - to - neuron communication at synapses: synaptophysin and a glutamate receptor protein.
mThy1 - AS mice administered only control IgG1 suffered dendritic atrophy (as suggested by reduced staining with MAP2) and synaptic loss (evaluated with postsynaptic density - 95 (PSD - 95) and synaptophysin) across several regions of the brain, but this neurodegenerative damage was substantially prevented in mice administered 1H7, 5C1, or 9E4.
Aged mutant amyloid precursor protein mice with established disease showed a near complete restoration in levels of synaptic and neuronal proteins after exposure to young blood in parabiosis (synaptophysin P =.02; calbindin P =.02) or following intravenous plasma administration (synaptophysin P <.001; calbindin P =.14).
[15] Significant recalcitrant (proteinase K - resistant) AS aggregate accumulated in the neuronal synapses of untreated PDGF - AS mice, as indicated by colocalization with synaptophysin staining; AFF 1 treatment significantly cleared this depot as well (Figure 3 (d)-RRB-.
Ginger significantly increased nerve growth factor (NGF), which stimulates the growth of new neurons, and synaptophysin and PSD - 95, two indicators of higher synapse formation.