Sentences with phrase «of synovial cells»

Nature designed a cartilage protection and lubrication system consisting of synovial cells and synovial fluid that is sealed inside a synovial membrane.

Not exact matches

When cells that produced IL - 21 were put in culture with synovial fibroblasts (which are the main contributors to joint inflammation in rheumatoid arthritis), they induced the production of proinflammatory cytokines by these synovial fibroblasts, and cells that do not produce IL - 21, did not demonstrate this same outcome.

Adenocarcinoma of the Appendix, Anal cancer, Breast Cancer, Cancer, Squamous cell carcinoma, Colorectal Cancer, Esophageal Cancer, Esthesioneuroblastoma, Hodgkin lymphoma, Intrahepatic cholangiocarcinoma, Laryngeal cancer, Lip and oral cavity cancer, Liposarcoma, Liver cancer, Multiple myeloma, Nasopharyngeal carcinoma, Non-small cell lung cancer, Oral cancer, Osteosarcoma, Pancreatic cancer, Rectal Cancer, Salivary Gland Cancer, Stomach cancer, Synovial sarcoma, Testicular cancer, Tongue cancer, Vaginal cancer, Bladder cancer, Cervical cancer, Prostate cancer, Non-Hodgkin lymphoma, Brain Cancer, Thyroid Cancer, Ewing Sarcoma, Extrahepatic bile duct cancer, Melanoma

Steven A. Rosenberg and colleagues at the Surgery Branch of the National Cancer Institute demonstrate that adoptive immunotherapy with CD8 + T cells genetically engineering to recognize the NY - ESO - 1 antigen could induce significant tumor regressions in patients with metastatic synovial sarcoma and melanoma.

Histopathology in Tg197 mice is characterized by infiltration of inflammatory cells, synovial hyperplasia, articular cartilage destruction and bone erosion symptoms, closely resembling those of human rheumatoid arthritis.

SDF - 1 is expressed in synovial epithelial cells and it has been reported that persistent induction of CXCR4 by stromal derived factors, such as TGF - β led to SDF - 1 mediated accumulation of CD4 T cells within the rheumatoid joint [44].

When a gastric spindle cell tumor is observed, the possibility of synovial carcinoma, besides common mesenchymal tumor, should also be considered.

Figure 2: Representative histology images of A: wild type and B: Tg197 animals at 7 weeks of age depicting the symptoms of Infiltration of inflammatory cells, Synovial hyperplasia, Articular cartilage destruction and Bone erosions evident as Tg5453 arthritic pathology.

Cells within the site of inflammation, the synovial tissue, in rheumatoid arthritis patients seem to still actively synthesise the active vitamin D3 derivative and express the receptor.

Synovial sarcoma is a cancer in the joints with a five - year and ten - year survival for people with Grade 3 tumors or metastatic disease of less than 25 % and 15 %, respectively, and Myxoid round cell liposarcoma is a malignant tumor that most often occurs in the deep - seated soft tissues of the extremities.

The synovial tissue is enriched in phenotype - committed, inflammatory memory T cells, which show a significantly reduced response to the anti-inflammatory effects of 1,25 -(OH) 2D3.

Soft Tissue Sarcoma Opportunity: in both our monotherapy single arm Phase 1 and combination randomized Phase 2 studies, we are focusing on two types of sarcoma where we believe there is significant unmet need: synovial sarcoma and Myxoid round cell liposarcoma.

The randomized, open label Phase 2 trial is ongoing and evaluating CMB305 and atezolizumab in patients with locally advanced, relapsed, or metastatic synovial sarcoma or myxoid / round - cell liposarcoma, two types of sarcoma that tend to express NY - ESO - 1 broadly.

The most common tumors of the joint include synovial cell sarcoma, histiocytic sarcoma, myxomas and other sarcomas.

These cells are also responsible in part for the formation of synovial fluid, the lubricating fluid in the joint capsule.

Other types of bone cancers include synovial cell sarcoma, hemangiosarcoma, chondrosarcoma and fibrosarcoma.