Sentences with phrase «of syntaxin»

When elevating calcium ion concentration directly at the presynaptic terminal with the use of caged calcium, cleavage of SNAP - 25 by botulinum toxin A (BoNT / A) produced a strong reduction in the calcium sensitivity for release, whereas cleavage of syntaxin using BoNT / C1 and synaptobrevin using tetanus toxin (TeNT) produced an all - or - nothing block without changing the kinetics of remaining vesicles.

Thus, the closed conformation of syntaxin - 1 gates the initiation of the synaptic vesicle fusion reaction, which is then mediated by SNARE - complex / Munc18 -1 assemblies.

Not exact matches

The team concluded that UNC - 13 does indeed unfold syntaxin and is therefore vital to the dispatch of nerve signals and memory.

When the scientists eliminated UNC - 13 in worms that produced normal syntaxin, however, the flow of neurotransmitters stopped, paralyzing the animals.

Before the fusion of synaptic vesicles with the plasma membrane, a protein complex is thought to form between VAMP — an integral membrane protein of the vesicle — and two proteins associated with the plasma membrane, SNAP - 25 and syntaxin.

Axel Brunger (Yale University) and Jahn confirmed and extended these ideas when they reported the high - resolution structure of VAMP / synaptobrevin, syntaxin, and SNAP - 25 in 1998.

Work by Scheller, Jahn, John Heuser (Washington University School of Medicine, St. Louis), and others advanced the concept that VAMP / synaptobrevin and syntaxin form coils that wrap around each other along their lengths, thus drawing together the membranes in which they're embedded.

Each SNARE complex consists of four Î ± - helices aligned in parallel, with syb2 and syntaxin - 1A contributing one helix and SNAP - 25 contributing two helices.

SNAP - 23 and syntaxin - 2 localize to the extracellular surface of the platelet plasma membrane.

Rothman also proposed that SNAP - 25, VAMP / synaptobrevin and syntaxin represent members of a large family of proteins, different forms of which are involved in membrane fusion in all cells, and in different compartments within cells.

[14] ARA also activates syntaxin - 3 (STX - 3), a protein involved in the growth and repair of neurons.