Sentences with phrase «of system level change»

Not exact matches

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

Inadequate flood protection infrastructure, which right now might not contain high tides in El Nino years; Lack of action on annual sediment removal from spring freshets, which each year move over 30 million m3 of sediment and leave about 3 million m3 of silt in the navigation and secondary channels of the lower reaches; and, By the end of this century sea levels at the mouth of the river could potentially rise more than one meter due to climate change overtopping the diking system.

There is one system which must be replaced, but there are also various different levels of change and varying times at which changes need to be implemented, not to mention the very many different places in which the changes will take place and the individuals in each of those places who will be working together to achieve that goal.

The deeper point of the critics of process thought is that subsuming other creatures into the ethical system worked out in modernity to guide relations among people does not change us at the needed level.

Through the use of its high - pressure processing (HPP) system, the company reduces Vibrio bacteria levels to non-detectable levels, but without the use of heat and any change to the product's texture.

It takes a significant mind set change and a high level of management to implement organic systems.

Many pregnant women experience some level of dizziness or light - headedness when pregnant, a result of significant changes to your cardiovascular system.

Because premature or sick babies need different levels of stimulation for their development, St. John implemented a variable light and sound system that can be changed for each baby's developmental stage.

First, the infant has experienced higher levels of cortisol from the mother's depression during pregnancy, thus changing their developing stress responses system.

(No, I am not claiming she had any sexual stimulation from the breastfeeding, but I am curious if the act of breastfeeding releases hormones into the mother's system, or if stopping breastfeeding and weaning the child changes the levels in the mother's body.)

The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, 53

All contract documents between SSNIT and Perfect Business Systems including all Change Requests and Services Level Agreements (SLA) for the provision of your Operations Business Suite (OBS) software

Other policies can be highly local, for example, health coverage could easily be done on a state or even county level without an easy way for the policies to be circumvented - sure, people can move to a different state / county but what counts as a policy in this case is the obligation residents have to pay in to the system and what their benefits are from it, so moving from state to state would not subvert the policies, it just changes the number of people subject to these policies.

A minimum step would be to implement a new tier (VI) of the current pension system model which reinstates the employee contribution of 3 percent, lengthens the number of years of service required to reach maximum benefit levels, and makes other changes to limit the cost of the benefits to be provided.

The department also provided technical guidance to the water systems on temporary changes they could make to lower the levels of cyanotoxins.

Dr. Vanden Wyngaard and district staff will provide an overview of state exams and how the Common Core Learning Standards are changing instruction for students at all grade levels, as well as information about how the tests are used in the new statewide evaluation systems for teachers and principals.

Gottfried's willingness to even explore the idea is a major change, and speaks to the level of the need of hospitals across the state, who are finding payments to doctors slashed, and their delivery systems upended.

Changing the system would mean putting more financial burden onto the state governments and federal government which in turn would require an increase of state - level and federal - level taxes.

In the mayor's version, he would appoint the panel and it would have a narrow mandate, limited to charter changes aimed at improving the city's campaign finance system — including lowering the maximum levels of campaign contributions to candidates — and encouraging voter participation in elections.

He announced changes to the social housing system: for existing social tenants, rent levels will remain unchanged, but new tenants will be offered intermediate rents at around 80 % of the market rent.

A new analysis suggests New York might deal with sea level rise and flood risk by a system of small levees and raising buildings unless climate change is worse than anticipated

We have simulated a level of change that some systems have already seen and others will see.»

These changes indicate that the ocean has absorbed more than 80 percent of the heat added to the climate system: this heating is a major contributor to sea - level rise.

Using an earth system modeling approach, Deutsch and scientists at the National Center for Atmospheric Research and the Georgia Institute of Technology mapped out changing oxygen levels across the world's oceans through the end of the 21st century.

«Our studies imply that the change of oxygen levels in different tissues can be sensed by Treg cells and that this process is critically important for maintaining the correct balance between activation and suppression of the immune system,» says Liu.

Next, the researchers turned this positive system negative by adjusting the lasers to change the atoms» energy levels so that the majority of the particles were high energy.

Applications include showing how the planet's surface changes over time, including through tectonic activity and sea level change; plotting the trajectories of ballistic missiles and satellite orbits; and making topographic maps and GPS systems more accurate.

«This study takes an integrated approach that addresses the need to advance Arctic environmental research at the system level, a challenge that has been recognized by the broad scientific community as necessary to improve predictions of future change,» said Cox.

Tipping points happen when the components of a system respond gradually to an external force until a level of change is reached at which the response becomes non-linear and synergistic.

Some may stem directly from how the altered digestive system works — secreting different levels of hormones, for example — or changes in nerve cells that communicate with the gut.

His team is also looking at how a robotic visual system can build up a picture of its world and adapt to changing conditions, varying light levels or even seasons.

«The Earth's current system of plate tectonics prevents drastic changes in surface water levels, with wet rocks efficiently dehydrating before they enter the Earth's relatively dry mantle.

The ocean conveyor system, Rutgers scientists believe, changed at the same time as a major expansion in the volume of the glaciers in the northern hemisphere as well as a substantial fall in sea levels.

Earth System Threshold Measure Boundary Current Level Preindustrial Climate Change CO2 Concentration 350 ppm 387 ppm 280 ppm Biodiversity Loss Extinction Rate 10 pm > 100 pm * 0.1 - one pm Nitrogen Cycle N2 Tonnage 35 mmt ** 121 mmt 0 Phosphorous Cycle Level in Ocean 11 mmt 8.5 - 9.5 mmt — 1 mmt Ozone Layer O3 Concentration 276 DU # 283 DU 290 DU Ocean Acidification Aragonite ^ ^ Levels 2.75 2.90 3.44 Freshwater Usage Consumption 4,000 km3 ^ 2,600 km3 415 km3 Land Use Change Cropland Conversion 15 km3 11.7 km3 Low Aerosols Soot Concentration TBD TBD TBD Chemical Pollution TBD TBD TBD TBD * pm = per million ** mmt = millions of metric tons #DU = dobson unit ^ km3 = cubic kilometers ^ ^ Aragonite is a form of calcium carbonate.

«No developing country in the world has a climate law, let alone a climate law that has this vision and this ambition, that integrates all of the sectors at the national level in a system for climate change,» said Vanessa Perez - Cirera, head of climate and energy programs for WWF Mexico.

Cellular - level changes to a part of the brain's reward system induced by chronic exposure to the psychoactive component of marijuana may contribute to the drug's pleasurable and potentially addictive qualities, suggests a study in young mice published in JNeurosci.

Continued emissions of greenhouse gases will cause further warming and long - lasting changes in all components of the climate system, increasing the likelihood of widespread and profound impacts affecting all levels of society and the natural world, the report finds.

Revised goals would also need to reflect the dynamic nature of the system and developing constraints imposed by climate change and sea - level rise.

For example, a large body of research has found switching to an entirely vegetarian diet would make a huge difference on the carbon footprint of our food system — the Climate Change, Agriculture and Food Security research program reports that if the global population were to reduce or cut its meat intake, it would halve the cost of mitigation actions needed to stabilize carbon dioxide levels to 450 parts per million by midcentury — but for many people that is not in the cards.

Of course, while short - term changes in sea level can be predicted fairly accurately based on the motions of the moon and sun, it is a lot harder predicting the ups and downs of the average global surface temperature — there is a lot of noise, or natural variation, in the systeOf course, while short - term changes in sea level can be predicted fairly accurately based on the motions of the moon and sun, it is a lot harder predicting the ups and downs of the average global surface temperature — there is a lot of noise, or natural variation, in the systeof the moon and sun, it is a lot harder predicting the ups and downs of the average global surface temperature — there is a lot of noise, or natural variation, in the systeof the average global surface temperature — there is a lot of noise, or natural variation, in the systeof noise, or natural variation, in the system.

Systems biology provides better methods of drug discovery: research teams can measure changes in genetic activity, protein levels and cellular behavior of the immune system in response to a potential vaccine.

These variations originate primarily from fluctuations in carbon uptake by land ecosystems driven by the natural variability of the climate system, rather than by oceans or from changes in the levels of human - made carbon emissions.

Levendosky said prenatal abuse could cause changes in the mother's stress response systems, increasing her levels of the hormone cortisol, which in turn could increase cortisol levels in the fetus.

So researchers assumed, Golombek says, that higher levels would increase the sensitivity of the circadian system and, in the process, «accelerate adaptation to a changing light schedule.»

The researchers examined various reconstructions of past temperatures and CO2 levels to determine how the climate system has responded to previous changes in its energy balance.

To gain an understanding of the mechanism that connects low mtDNA levels with a cellular change that leads to cancer and metastasis, Guha, Avadhani and their colleagues set up two systems by which they could purposefully reduce the amount of mtDNA in a cell.

Since the evapotranspiration rates of the study's cropping systems held steady across several years of varying precipitation levels, the study also suggests that crop evapotranspiration rates may not be as sensitive to climate change as is currently assumed.

«We now have a tool to control temperature on a cellular level, and we can study how biological systems react to temperature change,» says Peter Maurer, a physicist at Harvard University in Cambridge, Massachusetts, and a member of the team publishing the result today in Nature.

«In addition to a proper diet, the results suggest that in order to achieve a profound change in the behaviour of citizens towards healthy lifestyles, public bicycle systems such as Valenbisi play a strategic role in promoting health, as they favour the increase in the levels of physical activity and the reduction of body weight», concludes Javier Molina.

«We therefore concluded that many of these discarded kidneys were in fact quite usable, and that systems - level changes are needed to encourage better utilization of this valuable but scarce resource,» said Dr. Husain.