Sentences with phrase «of targeted therapies»

Next, his laboratory hopes to pursue research and development of targeted therapies.

Researchers are already beginning to test combinations of targeted therapies in the clinic.

The paper also highlights the need for future trials to improve efficacy and toxicity profiles of targeted therapies in this field.

While the combination of targeted therapies improves patient outcomes, any remaining cancer cells can lead to drug resistance.

However, some small molecule drugs can cross this barrier and form the basis of targeted therapies.

They found that the fetal breast stem cells are sensitive to a class of targeted therapies that already exists, so these therapies might also work in triple negative breast cancers.

One way to do this is to use combinations of targeted therapies.

However, with our increasing understanding of lung cancer biology has come the advent of targeted therapies to combat this devastating disease.

«Previous bacterial infection increases risk of newly - diagnosed Sjögren's syndrome: Identifying trigger will hopefully help future development of targeted therapy for patients suffering from this debilitating disease.»

Analysis of 355 biopsied tumors from patients who acquired resistance to EGFR inhibitors, the most common form of targeted therapy for NSCLC, found that mutations frequently varied between biopsies and that nearly one in five patients harbored more than one type of genetic resistance to treatment.

Another 11 % are of the Her2 - enriched subtype, a group whose prognosis has improved since the development of targeted therapies against Her2 (e.g. Herceptin).

At SEngine we are working to expand the pool of available drugs and, ultimately, be able to offer the patients a larger set of targeted therapies with our P.A.R.I.S test.

Predictive biomarkers of response are becoming increasingly important in the development of effective clinical trials of targeted therapies.»

The primary aim is to investigate the use of targeted therapy using antibodies and antibody - conjugates and remove toxic chemotherapy and radiation from the treatment to maintain high cure rates and decrease late effects.

«The field of targeted therapies in gliomas holds a lot of promise, and IL13Rα2 is in an optimal position to materialize these promises,» explained corresponding author Sadhak Sengupta, PhD, assistant professor of neurosurgery at BUSM and principal investigator of the Brain Tumor Lab at Roger Williams.

«Capturing the Spectrum of Hereditary Cancers: A Moving Target in the Setting of Targeted Therapy» Hetal Vig, MS Assistant Professor of Medicine Rutgers Robert Wood Johnson Medical School Board Certified Genetic Counselor Rutgers Cancer Institute of New Jersey

Several types of targeted therapy may be used to treat multiple myeloma and other plasma cell neoplasms.

It's based on solid data and I hope we'll make a big difference because if we can merge the high response rate and the elegance of targeted therapy with the durability of responses from immunotherapy, I feel we will make a big difference in treating cancer.

This prognosis guides decisions for subsequent courses of targeted therapy, and further biopsies are not routinely obtained, given the invasive nature of rebiopsy in the lungs.

«These new drugs are opening the door for more avenues of targeted therapy for the future,» says American Cancer Society president Ralph Vance, a professor of medicine at the University of Mississippi School of Medicine.

While the costs of targeted therapy may remain high, the cost of diagnostic testing for such genetic rearrangements is low.

This strategy would not be cheap, but neither is doling out a string of targeted therapies only to watch them all eventually fail.

Over the past 2 decades, few effective treatments for this cancer type have been identified, as PanNETs» heterogeneity has complicated the design of targeted therapies.

«New targeted therapy schedule could keep melanoma at bay: Optimizing the timing of targeted therapies for melanoma reverses tumor growth, and resistance can be mitigated..»

«Although some non-small cell lung cancer patients have increased benefit of targeted therapy or immunotherapy instead of chemotherapy, for some groups of patients with NSNSCLC, chemotherapy has been the standard treatment for more than 30 years,» Gandhi notes.

That trend is problematic considering that African - Americans — the most at - risk population for multiple myeloma — have different genetics that can affect how this type of cancer progresses and what kind of targeted therapies are most effective, said Zarko Manojlovic, lead author of the study.

The emphasis now is to store samples from almost every major study with correlative science in mind, and this is essential if we are to understand disease biology, mechanism of response and resistance to therapy in the era of targeted therapy and precision medicine.»

«In the last few years we've seen the introduction of targeted therapies, also known as precision medicine,» says allergist Mark Boguniewicz, MD, ACAAI member and lead author on a soon - to - be-published Atopic Dermatitis Yardstick.

Researchers developed the strategy as a way to develop inhibitors of «undruggable» proteins and overcome drug resistance, a common shortcoming of targeted therapies.

This work shows that the tumor microenvironment itself can compromise the efficacy of targeted therapies and should be taken into account as new treatment approaches are developed.»

For Olver, the matter of equity of access will grow along with the potential of targeted therapy and so - called personalized medicine.

The emergence of new anti-EGFR agents that can target resistant clones has resulted in further evolution of the landscape of targeted therapy against brain metastasis from primary NSCLC.

A lengthening procession of targeted therapies (Herceptin, Gleevec, Tarceva, Zelboraf) attempt to block various accelerators, and they often succeed in bringing a tumor to a screeching halt — until the malignancy activates a different gas pedal and returns to the road.

Identifying tumor - specific biomarkers to optimize selection of targeted therapies and to better predict response to therapy

As Elie Dolgin finds out, drug companies hope to change that, with the first wave of targeted therapies that reboot the body's backup system now entering clinical trials.

We are developing the next generation of targeted therapies where we eliminate the synthetic lethal partner of the three most common cancer - causing genes: MYC, TP53 and KRAS.

Dr. Sordella and her team propose a novel theory of how some cancers circumvent the killing power of targeted therapies...

Researchers at Boston University School of Medicine (BUSM), in collaboration with researchers from the City of Hope, are looking toward novel therapeutic strategies for the treatment of GBM in the form of targeted therapies against a unique receptor, the interleukin - 13 receptor α chain variant 2 (IL13Rα2).

This pathway is currently the focus of development of targeted therapy for moderate - to - severe eczema, suggesting that these same agents being tested in adults could also be useful in young children.

The research team also found mutations in the PIK3CA gene, which has been well studied in cancer and is already the focus of several clinical trials of targeted therapies.

Testing for the EGFR mutation and ALK rearrangements and the use of targeted therapies have given lung cancer patients the chance for survival, along with improved quality of life and time with loved ones.

«If our findings are confirmed by additional studies, they may open doors to the development of targeted therapies against the tumor subtypes more likely to affect African Americans and potentially help reduce racial disparities in breast cancer.»

Targeted Oncology keeps physicians up - to - date on the rapidly evolving field of targeted therapies and personalized medicine.

Histone deacetylase (HDAC) inhibitor therapy is a type of targeted therapy that blocks enzymes needed for cell division and may stop the growth of cancer cells.

If we can merge the high response rate and the elegance of targeted therapy with the durability of responses from immunotherapy, I feel we will make a big difference in treating cancer.

«We are looking to optimize the combinations of targeted therapies and the scheduling of those therapies so we can improve tumor shrinkage and minimize potential toxicities for a patient,» said Andrew Aplin, PhD, Associate Director for Basic Research and the Program Leader for Cancer Cell Biology and Signaling (CCBS) in the NCI - designated Sidney Kimmel Cancer Center at Jefferson Health.

Thus our studies on MELK are critical for guiding the development of targeted therapies in basal - like breast cancer.

In work that heralds a new, more potent form of targeted therapy for cancer, Dana - Farber Cancer Institute scientists have devised a chemical technology that doesn't just disable malevolent proteins in tumor cells, as current agents do, but destroys them.