Sentences with phrase «of telomere»

Each child will have a buccal cell swab taken for measurement of their telomere length, and each adult will have a 15 mL of venous blood sample taken for fasting glucose test, glycosylated haemoglobin test and full lipid profile test.

In addition to parent - proxy reports of children's general health, measurement of telomere length in children will provide more convincing evidence on the biological health of the children at cellular level.

a diet rich in phytochemicals from colorful plant foods like vegetables, fruits, nuts, spices, and teas can reduce oxidative stress and slow the processes of telomere shortening.

This is important, since the rate of change of your telomere length is very individual and can be affected, both positively and negatively, by many contributing factors — including genetics, lifestyle, stress and environment.

There are many lifestyle choices that can lead to an increased loss of telomere length, thus encouraging the aging process.

, to gain a fuller understanding of telomere status in order to implement the most effective wellness solutions.

«Findings to date reveal that inflammation causes DNA damage through the disruption of telomere function.

Studies have shown a diet rich in phytochemicals from colorful plant foods like vegetables, fruits, nuts, spices, and teas can reduce oxidative stress and slow the processes of telomere shortening.

Check my Snapchat at BenGreenfieldFitness.com/snapchat and you will see some shocking news I just discovered about reversal of my telomere shortening and my longevity N = 1 experimentation.

In addition research has shown that those individuals that have higher levels of EPA and DHA (found in cold water fish), have a shorter rate of telomere shortening, which is the biological aging marker, so this means the aging process is slowed down.

My understanding is the point of the Telomere Video is to show support for Eating more plant - based whole foods to increase your telomere length, and adding a bit of exercise doesn't hurt.

In this podcast I discuss some of the mechanisms by which chronic stress (and rumination) affect the brain and brain aging, the gut and inflammation, the immune system, and biological aging through acceleration of telomere shortening.

A decreased rate of telomere shortening can thus be equated with a decelerated rate of aging.

In fact, the degree of telomere shortening was equivalent to an additional 4.6 years of cellular aging.

Scientists were examining data which kept records of telomere length.

A lot of regenerative medicine research is focused on the regeneration of telomere length.

It's known that regular physical activity reduces mortality and prolongs life, and it's now known that part of that advantage could be as a result of telomere preservation.

Data from 5,823 individuals was analyzed, taken from one of the few survey indexes which include values of telomere lengths for study participants.

To put this in perspective, that's the same degree of telomere shortening seen with daily smoking — which suggests that sugary soda is as dangerous as cigarettes.

Every time a cell replicates, a tiny bit of telomere is lost, so they get shorter with age.

Transfer of telomere - adjacent sequences to linear plasmids by recombination.

Julia's lab studies chromosome organization and the maintenance of genome integrity, with mechanisms of telomere function as a springboard.

The study, «Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study,» This work was supported by the Genetic Associations and Mechanisms in Oncology Network, Genetics and Epidemiology of Colorectal Cancer Consortium, the National Cancer Institute, the National Institute on Aging, the Cancer Research Foundation, the Wellcome Trust, and the National Health and Medical Research Council.

This little - heralded, meticulous investigation into the effects of ablation of the telomerase catalytic subunit in mice with human - like telomeres provides us with strong reassurance that, should it prove to be the preferred approach for implementing the OncoSENS strategy, the effects of knocking out TERT would be limited to those dictated by the loss of telomere - lengthening per se, and would not lead to an unintentional loss of some essential but hitherto - unknown phsyiological function.

Telomere shortening induces cell intrinsic DNA damage checkpoints and cell extrinsic alterations that impair the stem cell function and maintenance during aging of telomere dysfunctional mice.

Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice.

There will be a $ 10.00 extra charge for analysis of each additional cell by SKY, karyotyping by G banding, Sister Chromatid Exchange assay, scoring of Telomere - signal free ends and T - SCE.

The information generated here should provide novel insights into the basic mechanisms of telomere replication and length homeostasis.

As a result we now have an appropriate human cell system with which to address the mechanisms of telomere regulation during cellular aging and the early steps of tumor formation.

The association of telomere length and cancer: a meta - analysis.

I cross fingers gene therapy is the big one though cautiously optimistic (lackluster fail target results study after study) by way of telomere gene control.

We also identified a «meditation effect» within the regular meditator group, characterized by a distinct network of genes with cellular functions that may be relevant to healthy aging, and this network was associated with increased expression of a number of telomere maintenance pathway genes and an increase in measured telomerase enzymatic activity.

A novel fission yeast mei4 mutant that allows efficient synchronization of telomere dispersal and the first meiotic division.

The SMC5 / 6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere - binding proteins.

Analysis of telomere length and telomerase activity.

Recently, TRF2 deficiency was reported to radiosensitize human Mesenchymal Stem cells through destabilization of the telomere [37].

A novel disrupter of telomere silencing 1 - like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)- activated gene expression.

To understand how telomerase RNA participates in mechanistic aspects of telomere synthesis, we studied a conserved secondary structure adjacent to the template.

Tankyrase binds to the telomeric protein TRF1 (telomeric repeat binding factor — 1), a negative regulator of telomere length maintenance.

The length of the telomere «caps» of DNA that protect the tips of chromosomes may predict cancer risk and be a potential target for future therapeutics, University of Pittsburgh Cancer Institute (UPCI) scientists will report today at the AACR Annual Meeting in Washington, D.C.

Intriguingly, the study also found that drugs called statins, which are better known for their cholesterol - lowering properties, appeared to alleviate the effects of telomere damage — and may even have protected telomeres against degradation.

«This suggests that statins were protecting against the worst cases of telomere degradation.

Individuals with longer telomeres or slower rates of telomere loss have been shown to have greater longevity in a wide range of species.

But not all of the telomere is copied each time; telomere caps tend to be shorter in the copies.

One strategy, which occurs in about 90 percent of cancers, requires increase production of a telomere - elongating enzyme called telomerase.

This continuous reduction of telomere length functions as a «molecular clock» that counts down to the end of cell growth.

Human diseases that include dyskeratosis congenita, aplastic anemia, and idiopathic pulmonary fibrosis have been genetically linked to mutations that negatively affect telomerase activity and / or accelerate the loss of telomere length.

Each time a cell divides, some of the telomere is lost.

Yamaki explained that every time a cell replicates, a tiny bit of telomere is lost, so they get shorter with age.

If you're in the bottom third of telomere length, your cardiovascular disease risk goes up 40 percent, which is not a trivial number.