Sentences with phrase «of thalidomide in»

Not exact matches

That thalidomide was not approved for sale in the United States was more of a bureaucratic fluke than anything else.

For some time, no one suspected that thalidomide was the cause of the significant increase in the incidence of phocomelia.

The company challenges the claim that thalidomide can cause limb defects that are confined to one side of the body, as seen in nine of the plaintiffs.

In a new twist of a historic tragedy, 13 Americans who say they are survivors of thalidomide are suing four companies for producing and distributing the notorious drug.

The lawsuit, filed in a Philadelphia court on 25 October, asserts that before thalidomide was pulled from markets around the world, samples were doled out to more than 1,200 physicians in the United States by three companies whose legal liabilities are now the property of Sanofi - Aventis US, based in Bridgewater, New Jersey.

«There are no representative, controlled studies documenting the true spectrum of thalidomide injuries,» they write in the lawsuit.

Holmes also notes that the relative paucity of thalidomide births in the United States means that few researchers there can speak with authority on the drug's effects.

The pharmacologist felt the animal studies submitted were not a good indication of possible toxicity in humans, since animals absorb thalidomide poorly.

President John F. Kennedy honors FDA medical officer Frances Kelsey in 1962 for her work blocking U.S. approval of thalidomide.

Meanwhile, reports of startling birth defects in babies born to mothers who had taken thalidomide were surfacing in Germany, Australia and other countries where the drug was legal — including Kelsey's native Canada.

In July 1962, a detailed story about America's close call with thalidomide appeared on the front page of The Washington Post, under the headline «Heroine of FDA Keeps Bad Drug Off Market,» with a photo of Kelsey.

FDA medical officer Frances Oldham Kelsey averted the tragedy of thalidomide birth defects in the United States

The company in - licensed thalidomide in 1992 and received FDA approval to market the drug (as Thalomid) for treating severe cutaneous manifestations of leprosy in 1998 and for treating multiple myeloma in combination with dexamethasone in 2006.

Starting in 2008, Marzia Lazzerini of the Institute for Maternal and Child Health in Trieste, Italy, and her colleagues randomly assigned 54 children with Crohn's to get daily thalidomide or a placebo.

A new study published in the March 12 issue of Science has identified one primary target of thalidomide's teratogenicity (potential to cause fetal malformations)-- a protein called cereblon.

In both zebrafish and chick embryos, adding a version of cereblon that doesn't bind to thalidomide seemed to blunt the drug's effects.

The prime example is thalidomide, which was outlawed in the 1960s because it caused birth defects but has now found a niche in the treatment of cancer and leprosy.

When they gave thalidomide to seven HHT patients, six had significantly fewer nosebleeds within a month of their first dose, Mummery and colleagues report online today in Nature Medicine.

A pilot study of thalidomide, published in 2001, found the drug improved blood counts in some patients and enabled others to become transfusion - independent.

Dr. Kelsey, 69, was honored for her successful crusade to prevent the marketing of the sleeping pill thalidomide in the United States.

THE NEWS THESE DAYS is rarely good, but two stories in recent editions of the newspaper were truly shocking: a posse of 15 policemen had stormed the Contemporary Arts Center in Cincinnati and, temporarily, closed down the traveling exhibition «Robert Mapplethorpe: The Perfect Moment»; and further, medical researchers had suggested that the drug thalidomide be reintroduced on the market as an effective therapeutic treatment

He was well known for playing a crucial role, as an expert witness, in winning compensation for the victims of thalidomide.

Meyer had said among other things that for 30 years the Contergan (thalidomide) manufacturer Grunenthal GmbH had had access to the medical files of the Contergan victims in the Contergan Foundation.

Representing Grünenthal on the major product liability case involving a claim for damages in over $ 204m filed by the Spanish Association AVITE (Asociación de Víctimas de la Talidomida en España) representing 184 victims of thalidomide, for alleged damages caused in the 1960's for the administration of thalidomide.