Sentences with phrase «of the adhesion molecules»

Current projects are investigating: 1) the expression of inflammatory genes during ischemia and reperfusion of kidneys during urology transplantation and in mouse models; 2) the expression of inflammatory genes and proteins in urine as markers indicating the presence of rejection in renal allografts; and 3) the role of adhesion molecules and chemokines in directing leukocyte infiltration into organ allografts.

In a cell - culture study, polyunsaturated fats did not alter TNF - α — mediated up - regulation of the adhesion molecules ICAM - 1, VCAM - 1, and E-selectin (34).

Lipoic acid also has been suggested to help inhibit production of adhesion molecules, the «sticky» molecules that capture fat along arterial walls, enabling it to help support a healthy cardiovascular system.

Resveratrol has been found to inhibit the expression of adhesion molecules in cultured endothelial cells (43, 44).

Not exact matches

Plants are not like us with pumping mechanism that pushes our blood around, so water moves up the vessel by adhesion (being attracted to the side of the vessel) and cohesion (water molecules being attracted to each other).

For example, hydrophilic polymers are often used to protect metals from fouling; water molecules accumulate on this polymer layer, which protects the metal against the adhesion of unwanted molecules or organisms.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

They lie in a region of chromosome 5 that sits squarely between two genes that produce cell - adhesion molecules, which govern how neurons connect to each other.

In a new study, NAIST scientists, in collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1 Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon migration.

Modulation of an NCAM - related adhesion molecule with long - term synaptic plasticity in Aplysia

The apCAM's are members of the immunoglobulin class of cell adhesion molecules and resemble two neural cell adhesion molecules, NCAM and fasciclin II.

This rapid, transmitter - mediated down - regulation of a cell adhesion molecule in the sensory neurons may be one of the early molecular changes in long - term synaptic facilitation.

Anyone who seriously proposes that there is a force beyond gene expression, signaling molecules, differential adhesion, and those kinds of mechanisms, just doesn't know what they are talking about.

Research groups in Munich, Essen, and Brussels have now detected a highly specific and exceptionally strong variant of this adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the Adhesion Molecules,» or CEACAMs for short, inside the stomach.

They coat the pad with a layer of anti-epithelial cell adhesion molecules (anti-EpCAM) which bond with CTCs but not with normal cells.

This growth is associated with a down - regulation in the sensory neuron of Aplysia cell adhesion molecules (apCAMs).

The neural cell adhesion molecule, N - CAM, appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis.

The team at Barts Cancer Institute, part of Queen Mary University of London, have found that a molecule, called focal adhesion kinase (FAK), signals the body to repair itself after chemotherapy or radiotherapy, which kill cancer cells by damaging DNA.

The lab previously found that Bam is required to repress the expression of E-cadherin, a cell - to - cell adhesion molecule that tethers adult stem cells to their tissue niches and promotes GSC self - renewal.

Now a more fine - grained picture of adhesion mechanics is emerging, thanks to a new tool developed in Illinois in recent years called a «tension gauge tether,» which allows scientists to measure cell mechanics at the single - molecule level.

Cells migrate by connecting their cytoskeleton — a network made up of proteins — to adhesion molecules which in turn get in contact with the surrounding connective tissue.

A small percentage of ASD patients carry mutations in genes encoding neuroligins, which are postsynaptic cell - adhesion molecules.

However, Professor Auguste's team, discovered the overexpression of intercellular adhesion molecule - 1 (ICAM - 1) in human TNBC cell lines and tissues, and demonstrated that it is a potential molecular target and biomarker for TNBC therapy and diagnosis.

We capitalized on one of the innate responses of microvascular endothelial cells, i.e., the up - regulation of cell adhesion molecules in response to inflammatory agents, to generate endothelial cell lines from different organs.

The constitutive and inducible expression of the endothelial cell adhesion molecules E-selectin, ICAM - 1, and VCAM - 1 was assessed by immunohistochemistry (Figs. 4, A — C) ⇓.

The constitutive expression of these endothelial cell adhesion molecules was very similar for most of the lines derived from different organs, i.e., very low expression levels of E-selectin and VCAM - 1 and more pronounced expression of ICAM - 1.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

Established cell lines exhibited several inherent endothelial properties, including the expression of constitutive and inducible levels of endothelial cell adhesion molecules E-selectin, intercellular adhesion molecule - 1, and vascular cell adhesion molecule - 1, internalization of acetylated low - density lipoprotein, and formation of loop structures on Matrigel surfaces.

To determine inducible endothelial cell adhesion molecule expression (E-selectin, VCAM - 1, and ICAM - 1), some of the chambers were given medium containing 10 ng / ml TNF - α for 4 — 6 h (these time points were selected to correlate with the known kinetics of endothelial cell adhesion molecule expression; Refs.

The ability to up - regulate endothelial cell adhesion molecules after exposure to cytokines was unaffected by repeated subculturing of cells, because we noted identical staining patterns for passage 30 cells (we did attempt to extend this observation to include later passage cells).

However, because IFN - γ is widely known to influence several endothelial properties, such as junctional integrity (21) and adhesion molecule expression (22), we elected to remove this cytokine from cultures immediately after the second session of cell selection.

Pilot studies using a variety of strategies suggested that this goal could be best achieved by stimulating primary organ cell cultures with TNF - α (10 ng / ml) and targeting cells expressing the endothelial cell adhesion molecules E-selectin and VCAM - 1 through a FACS - driven strategy.

The endothelial cells in insulin - receptor knockout mice expressed more of the VCAM - 1 adhesion molecule that helps white blood cells grab onto the growing plaques, and blood vessels gathered four times as many white blood cells.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

Nectin - 4 is a cell adhesion molecule that is expressed on a number of solid tumor cells.

In vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformation.

This locus contains a conserved non-coding element (CNE) upstream of three neuronal cell adhesion molecule (NCAM) genes, where the derived «sand» allele appears to disrupt a neuronal transcription factor binding motif.

Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells.

They do so by invading the niche space of neighboring GSCs and gradually pushing them out of the niche by increasing the cellular response to the adhesion molecule E-cadherin.

Then, we explore the adhesion properties of eumelanin molecules on a silicon surface and extract the electronic structure of the resulting system.

They will then examine other mouse models with mutations involved in cell - adhesion and extracellular matrix molecules for signs of RPE diseases.

The anti-inflammatory actions of platelet endothelial cell adhesion molecule - 1 do not involve regulation of endothelial cell NF - $ ąppa $ B.

Adopting the scheme of chemical disorder, which has been proved to successfully capture the variety of eumelanin protomolecules, we show that (1) the formation process of eumelanin protomolecules from the constituting monomers is generally hindered in a solvent environment with respect to vacuum and (2) key factors in improving the adhesion properties and band lineup of the molecules on an inorganic interface are the molecular electronic state and the planarity of their structures.

Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells.

Many of the lysosomal proteases are active at neutral pH and this would mean that they could potentially cleave cell surface receptors and cell adhesion molecules.

Almost all of these small neurons were identified to be cerebellar granule cells based on their morphology and that they were stained by anti-neural cell adhesion molecule L1 (Fig. 1A)[19].

Intercellular adhesion molecule - 1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.

His research interests have included the immunogenetics of diabetes, the biology of tumour - associated antigens and cell adhesion molecules, and ethical aspects of the design of trials involving human subjects.

Increased expression of Cd11b - a marker of macrophages [38] seen with L - arginine admininistration in WNIN / Gr - Ob rats, might be due to increased influx of inflammatory cells in the exocrine fraction via adhesion molecules [17].

Nanolithographic control of the spatial organization of cellular adhesion receptors at the single - molecule level.