Sentences with phrase «of the aggregation process»

«Our findings have challenged the notion of the aggregation process as a passive consequence of accumulating misfolded proteins,» says Stowers Investigator Rong Li, Ph.D., who led the study.

A summary of these measures is below, followed by a detailed description of the aggregation process and scale development.

Not exact matches

There are definite, predictable stages through which an aggregation of people go in the process of becoming a true group.

AgCAP started the sale process in March of the portfolio of 17 farms organised into five aggregations that operate broadacre cropping, irrigated, beef and dairy enterprises.

Also, as therapies are developed to treat protein - aggregation - based pathologies, it will be critical to consider that there may be many useful aggregates that should not be destroyed in the process of treating disease - causing aggregates.

Wolynes considers the new study a beachhead to launch others to determine the entire process of how memories form, as well as the implications for diseases like Alzheimer's and Parkinson's that involve protein aggregation.

«As they bump into others while moving within and between the resource sites, the process of behavioral gregarization is initiated, leading to the formation of local aggregations, which may in turn seed large - scale swarms.»

In close collaboration with his TUM colleagues Johannes Buchner, professor of biotechnology and Sevil Weinkauf, professor of electron microscopy, Reif determined that the small heat shock protein uses a specific non-polar beta - sheet structure pile in its center for interactions with the beta - amyloid, allowing it to access the aggregation process in two locations at once: For one it attaches to individual dissolved beta - amyloids, preventing them from forming fibrils.

The second challenge is that growing grains can be broken up in high - speed collisions, breaking them into a large number of smaller pieces and reversing the aggregation process.

A series of exciting recent studies suggested that the process of protein misfolding and aggregation implicated in various PMDs can be transmitted by administration of preformed, misfolded protein aggregates, in a way reminiscent of the transmission of prion diseases by infectious prions (Prusiner, 2012; Soto, 2012; Jucker and Walker, 2013).

The similarities between the molecular mechanism of prion propagation and the process of protein misfolding and aggregation in PMDs, suggest that misfolded aggregates have an inherent ability to be transmissible (Soto et al., 2006; Soto, 2012).

For discovery of new cancer genes and mutational processes, aggregation of tens of thousands of cancer genomes is needed — we are establishing a virtual marketplace for exchange of genomes and informatics and develop increased functionality through the COSMIC portal.

Alternatively, some researchers think that infection affects neural processing of APP, leading to an overproduction and then aggregation of amyloid - β (5), a telltale sign of Alzheimer's disease.

Aggregation promoting C - terminal truncation of alpha - synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease - linked mutations.

27: Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, Nuber S. Overexpression of the calpain - specific inhibitor calpastatin reduces human alpha - Synuclein processing, aggregation and synaptic impairment in [A30P] αSyn transgenic mice.

Neurodegeneration - associated aggregation - prone proteins are predominantly degraded by autophagy and therefore stimulating this process with chemical inducers is beneficial in a wide range of transgenic disease models.

Leukotriene B4 (LTB4) plays an important role in several cellular processes involved in inflammation, including oxidative metabolism, enzyme release and stimulation of neutrophil migration and aggregation.

The mechanisms by which vitamin E might provide this protection include its function as an antioxidant and its roles in anti-inflammatory processes, inhibition of platelet aggregation, and immune enhancement.

Aggregation of ShareBuilder orders for the same securities helps us keep execution and processing costs to a minimum.

This marks the completion of the first phase of a refinancing process that involves the aggregation of a 92MWp UK Solar PV portfolio of 17 companies consisting of 37 separate ground - mounted and commercial rooftop sites, as well as over 3,100 residential rooftop installations.

A distributed ledger (/ blockchain) to store legal contracts and to improve client visibility (LightningWarriors): a smart communications and aggregation tool to master the avalanche of legal communications and generate machine responses etc (smartcomms.ai): an app for SMEs able to conduct a full GDPR compliance audit (GDPR or Global Decentralised Process Renegade!)

His technical experience encompasses wireless communications and data networking including various aspects of LTE baseband processing, carrier aggregation, adaptive modulation and coding schemes, shared antenna systems and frequency coexistence management, satellite networking involving committed information rate (CIR), bandwidth optimization, very - small - aperture terminal (VSAT) design, non-cellular wireless technologies including NFC and RFID, video coding and communication protocols, hard drive technologies, Multimedia over Coax Alliance (MoCA) access networks, fiber optic networks, multimedia delivery as well as various software products and systems including financial trading platforms, payment networks, secondary mortgage market - related software solutions, electronic couponing, photo editing software, social and business networking applications, and enterprise software products.

In a similar vein, we are in the process of installing «enterprise - wide aggregation software».