Sentences with phrase «of the cell signalling machinery»

Our contributions to this field have helped to change the way endocytosis is perceived, from being simply a mechanism for signal attenuation to being a vital component of the cell signalling machinery that provides spatial and temporal dimensions to signalling events (1).

This rather simplistic view is now changing with emerging evidence that endocytosis is an integral component of the cell signalling machinery, regulating aspects such as the duration, intensity, integration and spatial distribution of signals.

Not exact matches

Another interesting aspect to the work is that it demonstrates the possibility of adding new machinery to human cells to enable them to make therapeutic agents in response to disease signals.»

With careful observation and experiments with mouse oocytes, the precursors of eggs, they've detected molecular signals that create an asymmetry in the machinery that drives meiosis, the cell - division process that gives rise to gametes.

While the PS is moving across the cell membrane and looking for a stronger chemical signal, only a few molecules of the breaking protein Cdc24 are present in the machinery.

Theoretically, once a particular codon — say, TAG — has been removed from a genome, the cell's protein - making machinery could be reprogrammed to assign TAG to an amino acid, instead of being a stop signal.

Because when the cell detects an EJC within a certain distance from a «stop» signal in a gene message, that is when it calls the NMD machinery into action, to halt decoding of the message and resulting in its degradation.

Clara Franzini — Armstrong writes about Annemarie Weber, «a major contributor to the renaissance of muscle biology research in the 1950s to 1970s, when the components of the contractile machinery were identified; novel views of muscle contraction and regulation were elucidated; and principles of energy transduction, motility and intracellular signaling common to all cells were revealed.»

We are using biochemistry and genetics to identify the proteins that enable neurite - specific neuropeptide localization and using cell - type - specific genetic manipulations to disable that machinery and thereby probe the behavioral function of extra-synaptic peptide signaling in specific circuits.

Prior to the new study, scientists thought that the machinery in a cell created signalling peptides by cutting fragments out of proteins in sequence, and displaying these in order on the surface of the cell.

Tumour cells are «glutamine - addicted» [1,2] because glutamine is coupled to mechanistic target of rapamycin (mTOR) signalling, which integrates signals from growth factors, energy status and amino acid nutrition and co-ordinates these signals with cell growth, cell cycle progression and antioxidant machinery [3].

Through a complicated and little understood signaling machinery — a domino effect of molecular reactions in a cell that ultimately produces a certain signal — Natural Killer cells then destroy such» stressed» cells.

Themis1 has been recently described as a new component of the TCR signaling machinery that controls thymic development of T cells.