Sentences with phrase «of the genome in»

In an attractive synthesis, such neighborhood - level risk factors might impart lasting epigenetic changes — the chemical overwriting of the genome in response to environmental cues.

Like treasure hunters combing a vast beach with metal detectors, ENCODE researchers sifted through their patch of the genome in multiple ways that are described, along with the results, in a Nature paper published online today and in a special issue of Genome Research.

We did not find any evidence for a so - called «positive selection» but instead found that many gene variants linked to schizophrenia reside in regions of the genome in which natural selection is not very effective in the first place.

It builds on a 2011 discovery by Berman and Laird that first determined loss of these DNA marks — called methyl groups — occurs in specific areas of the genome in cancer.

The study provides «compelling evidence» of alterations of DNA in several regions of the genome in children with CD, according to Professor Jack Satsangi of University of Edinburgh and colleagues.

That enabled the scientists to get roughly 85 percent of the genome in the right place.

«Because there are so many copies of these genomes in each cell, and because they're so conserved across all domains of life the mitochondrial genomes were the focus of our study.»

Subsequent analysis of two - thirds of the genome in the 2009 A (H1N1) isolated from more than a dozen pigs shows that it closely matches the human version of the virus.

Researchers investigated the glycophorin area of the genome in more detail than before using new whole - genome sequence data from 765 volunteers in the Gambia, Burkina Faso, Cameroon and Tanzania.

Stretch out all of the genomes in all of your body's trillions of cells, says Tom Misteli, the head of the cell biology of genomes group at the National Cancer Institute in Bethesda, Md., and it would make 50 round trips to the sun.

This approach, however, differs from liquid biopsies, including commercial tests, which only profile a relatively small portion of the genome in patients already diagnosed with cancer for the purpose of helping monitor the disease or detect actionable alterations that can be matched to available drugs or clinical trials.

Dillman explained that his research team also learned more about gene regulation and the evolution of genomes in general as it compared the five sequences with other nematodes.

Thus, eventually, it's the avoidance of competition and the process that I call endo - geno - symbiosis (i.e., the capacity of endogen «gene carriers» to share parts of their genome in a symbiotic relationship with their hosts, after the idea of «endosymbiosis» proposed by Sagan, 1967) that drives the expansion of the diversity of living beings.

In fact, the evolution of our genome in the face of the Black Death could explain why Europeans respond differently to some diseases and why they have different susceptibilities to autoimmune disorders.

The bug has not one, but four copies of its genome in separate compartments.

The second is chromosomal complexity, which reflects how much of the genome in the cancer cells has copy - number alterations.

The application of next - gen sequencing to RNA libraries (RNA - Seq), chromatin immunoprecipitates (CHiP - Seq), bisulfite - treated DNA, and regions of open chromatin (DNAse - Seq) makes it possible to interrogate many aspects of the genome in high - throughput fashion.

Dr. Rossi has shown that with the expression of RAD52, a protein not usually expressed in HDR, and dn53BP1, an altered form of 53PB1 (regularly found in the NHEJ pathway), he was able to enable efficient HDR at multiple points of the genome in patient - derived induced pluripotent stem cells.

According to Dr. Burgess, the team is now working to extend the period that sperm cells can be cultured, so there is more time to select cells that have the foreign gene inserted in specific areas of the genome in what is commonly called a «targeted gene knockout.»

Bacteria have one copy of their genome in each cell.

This difference likely reflects the biased sampling of the genome in previous studies towards regions of higher differentiation (e.g. centromeric regions).

With a diverse sample of genomes in hand, we sought differences in gene repertoire that are associated with gross morphological complexity.

Subsequently, 616 BEEHIVE patient samples were analysed to determine factors that influence successful amplification of the genome in four overlapping amplicons using the QIAamp Viral RNA Kit for viral RNA isolation.

The INFRAFRONTIER Research Infrastructure provides access to mouse models, data and scientific platforms and services to study the functional role of the genome in human health...

The Major Histocompatibility Complex (MHC) is a region of the genome in dogs that contains genes that encode a group of cell surface proteins known as Dog leukocyte antigens (DLA).

Not exact matches

Venter, who is one of the first people to sequence the human genome, co-founded the company in effort to discover early genetic markers for a variety of disorders.

A former health care investment analyst with a degree in biology from Yale University and current CEO of the company, Wojcicki is fascinated by the mysteries of the genome and what it can reveal about the human body.

In fact, a recent ranking of the top 20 «startup ecosystems» by research company Startup Genome listed three Canadian cities (Toronto ranked eighth, Vancouver, ninth and Waterloo, 16th).

Rõivas, the former Prime Minister, says Estonia is working on developing «precision medicine» that would tap into the genome data of its 1.3 million citizens in order to better diagnose illnesses, treat people, and design personalized drugs.

This low rate of Startup Leakage reflects the attractiveness of living in Barcelona,» reports Startup Genome.

I reached out to Dane Stangler, Startup Genome's Head of Policy, to see if he thought the turmoil would be a significant drag on Barcelona's startup ecosystem in the future.

According to the journal Nature, in 2008 the cost of sequencing a person's genome was about $ 10 million; today the expense hovers around $ 1,000, and that price is expected to continue to drop.

First, though, we need to touch on the genome of what most early - stage investors are looking for in a startup:

The company is selling a thing (the kit) by saying it can provide «health reports on 254 diseases and conditions,» including categories such as «carrier status,» «health risks,» and «drug response,» and specifically as a «first step in prevention» that enables users to «take steps toward mitigating serious diseases» such as diabetes, coronary heart disease, and breast cancer...» Most of the uses «listed on your website, a list that has grown over time,» the FDA writes, «are medical device uses [for the] Personal Genome Service.»

«We will be sending samples for genome sequencing to establish the specific strain of listeria,» the company said in a statement adding that the level detected was well within the range of government standards for the presence of listeria.

While some of Aziz's ideas still make me squeamish, machine learning, virtual reality, the Human Genome Project, and the internet of things will undoubtedly impact our lives in the future.

Until it ran afoul of the FDA, the company analyzed consumers» personal genomes in order to provide detailed summaries of their genetic risk for a host of common diseases (done through a spit kit sent by mail).

In their data set, Startup Genome found that 70 % of startups showed some form of premature scaling.

The biggest biotech fight of the century thus far, the heavyweight title bout between the Broad Institute of Harvard and MIT and the University of California over the ownership of the CRISPR - Cas9 genome - editing technology — or the Thrilla in Virginia, as I described it in December — is over.

Caribou Biosciences, which partners with Novartis and Intellia, has a technology that «enables simple, flexible targeting of any site in a genome.»

The company's genome kit, which was named «Invention of the Year» by Time magazine in 2008, tests for 36 recessive disorders, including sickle cell anemia and cystic fibrosis.

Phylogica has continued its march towards commercialisation of its game - changing drug delivery platform, after the Perth company boosted its disease - fighting genome library in the March quarter.

Also found in the water bear genome were more copies of an anti-oxidant enzyme and a DNA repair gene than in any other animal.

The platform is used for everything from analyzing seismic data to find promising places to drill for oil to looking at plant genomes in search of new hybrids.

With this in mind, the Materials Genome Initiative is building databases of material properties like strength, density and other things, and also includes computer models to predict what processes will achieve the qualities a manufacturer is looking for.

One concern is the fact that the technique is still fairly innacurate, and results in a lot of accidental mutations in other parts of the genome.

Lots of people talk about the promise of using genetics in pharma R&D, says Jeff Reid, Regeneron's chief of genome bioinformatics, «but they don't have a vision for sample flow.»

The commercialization of DNA sequencing (the reading of an organism's code) and synthesis (the writing of that code) has accelerated since the mapping of the human genome was completed in 2003.

But rather than buying up a genetic research outfit, it decided to build its own in the form of the Regeneron Genetics Center (RGC), an ambitious four - year old effort to sequence as many exomes (the protein - encoding part of the genome) as possible, pair them with medical records, and accelerate drug development.

[1:20] How the kindness of a stranger changed Tony's life [3:35] Peter Diamandis talks about the origins of X Prize [6:30] Technology helping the agricultural industry [7:00] Sequencing genomes [8:55] Life - work integration [11:15] Finding your highest calling in life [12:00] Reframing what is «impossible» [14:00] Strategy vs. psychology [15:00] Changing your state [16:00] The science of achievement, the art of fulfillment [19:00] Living in a beautiful state [24:00] Thinking 10x bigger [28:00] Surrounding yourself with a «nothing is impossible» community [29:00] The news pollutes your mind [31:00] Tony's natural gifts and core beliefs [33:30] Overcoming failure and criticism [37:45] Defining your environment [40:00] Life happens for you, not to you [42:00] Rituals and practices to up your game [46:30] Tony's priming process