Sentences with phrase «of the growth factor pdgf»

It then throws in plenty of growth factors (direct government funding, networking support, connections to customers, heavy promotion to outside investors, and relaxed regulations) and incubates them for years.

The thought is that by injecting PRP into an injured area, an increased concentration of growth factors is then available to heal whatever damage is present.

These studies have demonstrated higher levels of the growth factors that improve healing and lower levels of the growth factors that are thought to reduce healing rates.

Alysson Muotri at the University of California, San Diego, and his team created the mini-brains by exposing stem cells taken from the pulp of children's milk teeth to cocktails of growth factors that help them mature.

M.Y.: The company is focused in large part on coming up with specific combinations of growth factor receptor inhibitors that have therapeutic efficacy in cancer.

Drug candidates currently in late stage clinical trials comprise of growth factors, which are traditional protein - based biological drugs associated with high costs, and some trials have been prematurely terminated.

Nerves may be responsible for the release of growth factors or chemotactic agents necessary for the regenerative process.

To get more cells, researchers from Advanced Cell Technology in Worcester, Mass., grew clusters of human embryonic cells in a precise cocktail of growth factors and other cell - regulating chemicals that took several years to work out, says Robert Lanza, the firm's vice president of research and scientific development.

Changes in the presence of growth factors produced the teeth, which were consistent with those of archosaurs (the group that includes birds, nonavian dinosaurs, and crocodilians).

This finding is in accordance with earlier animal model studies, which have shown that physical activity increases the amount of growth factors in the brain and improves synaptic plasticity.

The significance of Fan and Tonks» research on FER is their discovery of how FER activates MET from below, i.e., in the absence of a growth factor docking at the receptor surface.

«Research shows a cause of gastrointestinal symptoms in Type 1 diabetes: Excess of growth factor binding protein damages colon - maintaining stem cells.»

When the mother's and father's copies of the Igf2 gene are both mistakenly turned on, for example, the fetus gets a double dose of growth factor.

At the time, culturing stem cells was notoriously hard, but after combing through previous lab experiments, another postdoc in Clevers's lab, Toshiro Sato, concocted a mix of growth factors that coaxed the gut stem cells to replicate in a dish.

According to the report, high levels of sFlt1 could result in a compromised vascular system by reducing the available amount of these growth factors in the blood supply.

When Oudhoff applied human saliva to skin - cell cultures scratched by a needle, however, he found that the concentrations of growth factors were too low to have any therapeutic effect.

By analyzing the sequence of the growth factor, the scientists isolated a 22 - amino acid section that is responsible for the powerful binding of PIGF - 2 to extracellular matrix proteins.

The group also tested low - dose topical application of growth factors on diabetic mice, which are a common model for impaired wound healing.

A group led by Jeffrey A. Hubbell at EPFL has found a way to vastly improve the efficiency of growth factors, while keeping their usage at low doses.

These cells were encouraged to grow into cultured red blood cells using a cocktail of growth factors.

Thus, future strategies for repairing the central nervous system might involve concocting even more potent mixtures of growth factors, like Sofroniew's «carrot,» that could be continuously infused or implanted near a patient's injury.

Some of the growth factors also have cancer - causing effects.

«For the first time, we were able to demonstrate, in surgically resected metastases, that treatment with bevacizumab in combination with chemotherapy before metastasectomy also changes the clinical significance of the growth factors as potential biomarkers,» explains Stefan Stremitzer, one of the lead investigators from MedUni Vienna's Department of Surgery.

Several research groups are pursuing gene therapy approaches to regenerate skin, such as using genes to control expression of growth factors involved in skin healing.

The researchers from the study group were able to show that upregulation of the growth factor VEGF - B, which is related to VEGF - A, in the primary tumor in the bowel prior to treatment was associated with a poorer prognosis, whereas upregulation of VEGF - B in the liver metastases after treatment was associated with a better prognosis.

In addition to providing a platform for studying the processes that regulate platelet production and related diseases, the researchers hope the platelets produced can be used as a source of growth factors for wound healing in regenerative medicine, including healing of ulcers and burns, and stimulation of bone tissue regeneration in dentistry and maxillofacial plastic surgery.

«Development of growth factor - free tissue adhesive porous films singularly capable of promoting angiogenesis.»

These include lipid lowering; protection from oxidative stress and inflammation; modification of growth factors that can promote cancer; inhibition of nutrient sensing pathways by amino acid restriction and gut microbiota - mediated production of metabolites.

«I had to develop a special, precisely defined cocktail of growth factors and a certain treatment method for the stem cells, so that they would differentiate in the desired direction,» Monzel describes her approach.

The researchers also have yet to determine the specific recipe of growth factors that would coax stem cells to create other types of sensory interneurons.

They first induced angiogenesis in mice through the injection of a growth factor called FGF - 2 and measured blood vessel development in the presence and absence of synthesised IP5.

Perhaps the ultimate solution to keeping transplanted stem cells alive will be to use helpers that give off a cocktail of growth factors, he suggests, as well as pre-conditioning for low oxygen conditions and scaffolds.

Cancer biologist Cun - Yu Wang of the University of Michigan in Ann Arbor and his colleagues set out to determine the role of growth factors in a cancer called he

Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells.

4 The downstream signaling pathways of some growth factor receptors was also intact because many of the cell lines exhibited proliferative responses to certain of the known endothelial cell mitogens.

Murat completed his PhD at NCSU focusing on systems biology of growth factor - mediated signal transduction pathways.

The three - dimensional vascularization of growth factor - releasing hybrid scaffold of poly (e -LCB- open -RCB-- caprolactone) / collagen fibers and hyaluronic acid hydrogel.

Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets.

Andrea Zieris (Werner, LG)-- «Modulation of growth factor functionality through immobilization in starPEG - heparin networks» (2012)

A team led by Akhilesh Gaharwar has now found that 2D nanosilicates (or nanoclays) can be used to grow bone and cartilage tissue in the absence of growth factors.

In mice with an altered level of the growth factor, there was no regression of the temporary blood vessels.

-- The symptoms result from an excess of the growth factor PDGF, which prevents the temporary blood vessels of the foetal stage from disappearing, which in turn prevents normal development of blood vessels in the retina, says Karin Forsberg Nilsson, professor at the Department of Immunology, Genetics and Pathology at the Rudbeck Laboratory, who directed the study.

Adding a gel made of growth factors allowed the cells to grow outwards, forming a series of tiny tubes running parallel to each other.

The result is an accumulation of senescent cells, which causes inflammation, tissue degradation and the production of growth factors that alter the tissue microenvironment, leading to disease.

«What we're seeing may not only be happening in limbs, but the action of these two families of growth factors could be very important for the genesis of a wide range of organs in the body,» said Juan Carlos Izpisúa Belmonte, a professor in the Gene Expression Laboratory at Salk and the principal author of the Cell paper.

He is internationally recognized for his work on the control of cell growth and fate by the TGF -(beta) family of growth factors.

The finding is based on studies of mice with altered levels of the growth factor PDGF in neural stem cells, which play a key role in the development of the eye.

PNNL recently filed a patent on the use of this growth factor - hydrogel complex for the stimulation of bone healing.

Six ovarian factors (BDNF, IGF - I, estradiol, GDNF, leptin and FGF2) were further studied based upon the expression of their receptors in oocytes and cumulus cells described above, as well as the availability of growth factor concentration information from previous animal model studies [1], [20], [21], [22], [23].

When breast cancer cells invade the bone microenvironment, they produce molecules that activate osteoclastic bone resorption, leading to the release of growth factors stored in the bone matrix to promote tumor growth.