«For the first time, we were able to demonstrate, in surgically resected metastases, that treatment with bevacizumab in combination with chemotherapy before metastasectomy also changes the clinical significance
of the growth factors as potential biomarkers,» explains Stefan Stremitzer, one of the lead investigators from MedUni Vienna's Department of Surgery.
Not exact matches
Important
factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our
growth strategy, including the timing, execution, and profitability
of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost
of accommodating, announced increases in the build rates
of certain aircraft; 6) the effect on aircraft demand and build rates
of changing customer preferences for business aircraft, including the effect
of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals
as a result
of global economic uncertainty or otherwise; 8) the effect
of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution
of key milestones such
as the receipt
of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation
of our announced acquisition
of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability
of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk
of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production
of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts
of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak
of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact
of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition
of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect
of governmental laws, such
as U.S. export control laws and U.S. and foreign anti-bribery laws such
as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect
of changes in tax law, such
as the effect
of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations
of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect
of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers,
as well
as the cost and availability
of raw materials and purchased components; 23) our ability to recruit and retain a critical mass
of highly - skilled employees and our relationships with the unions representing many
of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment
of interest on, and principal
of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness
of any interest rate hedging programs; 28) the effectiveness
of our internal control over financial reporting; 29) the outcome or impact
of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition
of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco
as a result
of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks
of doing business internationally, including fluctuations in foreign current exchange rates, impositions
of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.
The functional effectiveness
of such electronic sharing systems has been one
factor in the
growth of telecommuting
as an option for workers.
Some
of the possible excess in house prices could in the interval be tempered by
factors such
as income
growth, regulatory changes and modest price corrections along the way.
But
as we know, oil prices and Canada's overall economy will have a strong impact on the city's
growth in the future, and the possible effects
of the oil price drop were not
factored into our calculations.
Environment takes into account both physical and emotional
factors, and the average number
of hours worked each week; income considers mid-level salary and
growth potential; outlook measures potential for employment
growth and income
growth,
as well
as unemployment rates; and stress takes into account 11 different
factors including travel, deadlines, and interaction with the public.
It wasn't immediately clear how much
of the change reflected confidence that the tax - cut legislation moving through Congress will boost
growth, or other
factors such
as pickups in business spending and global
growth.
Those
factors partly help explain why Exxon is now seen by Wall Street
as a less - desirable investment than Chevron, which has several large oil and gas projects coming online by the end
of the decade, offering far - stronger
growth potential than Exxon.
Such risks, uncertainties and other
factors include, without limitation: (1) the effect
of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels
of end market demand in construction and in both the commercial and defense segments
of the aerospace industry, levels
of air travel, financial condition
of commercial airlines, the impact
of weather conditions and natural disasters and the financial condition
of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization
of the anticipated benefits
of advanced technologies and new products and services; (3) the scope, nature, impact or timing
of acquisition and divestiture or restructuring activity, including the pending acquisition
of Rockwell Collins, including among other things integration
of acquired businesses into United Technologies» existing businesses and realization
of synergies and opportunities for
growth and innovation; (4) future timing and levels
of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability
of credit and
factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope
of future repurchases
of United Technologies» common stock, which may be suspended at any time due to various
factors, including market conditions and the level
of other investing activities and uses
of cash, including in connection with the proposed acquisition
of Rockwell; (7) delays and disruption in delivery
of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits
of organizational changes; (11) the anticipated benefits
of diversification and balance
of operations across product lines, regions and industries; (12) the outcome
of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact
of the negotiation
of collective bargaining agreements and labor disputes; (15) the effect
of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect
of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect
of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to
as the Tax Cuts and Jobs Act
of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability
of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition
of conditions that could adversely affect the combined company or the expected benefits
of the merger) and to satisfy the other conditions to the closing
of the pending acquisition on a timely basis or at all; (18) the occurrence
of events that may give rise to a right
of one or both
of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee
of $ 695 million to United Technologies or $ 50 million
of expense reimbursement; (19) negative effects
of the announcement or the completion
of the merger on the market price
of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation
of their businesses while the merger agreement is in effect; (21) risks relating to the value
of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability
of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.
The ease
of shopping from over one thousand brands inside one app could be seen
as a major
factor in the 20 %
growth month over month for Spring.
«This trend could be due to several
factors (or a combination
of them): more startups being targeted for acquihires
as their
growth slows, capital availability leading to more ready cash on - hand, and a general consolidation
of certain industries (e.g., food delivery companies acquiring each other),» CB Insights wrote in a blog post.
A recent study found that 52 %
of millennials cited «
growth opportunities»
as their top motivating
factor when it comes to selecting which company they will work.
«While we see a potential drop in total number
of U.S. jobs created in 2017,
as reported by Kiplinger,
as well
as an overall expected drop in GDP
growth, the cannabis industry continues to be a positive contributing
factor to
growth at a time
of potential decline,» says De Carcer in a statement.
Stress,
as defined by the Jobs Rated methodology, is determined by 11
factors: travel, deadlines, working in the public eye, competitiveness, physical demands, environmental conditions, hazards encountered, the life
of oneself or others at risk, meeting and interacting with customers and / or the public, and the potential for job
growth.
The portfolio management team uses a variety
of investment strategies to search for companies suitable for investment in the fund, including
factors such
as growth in earnings, return on equity, and revenue.
(The late British economist Angus Maddison credited open trade
as one
of three
factors that mattered to income
growth and poverty reduction, along with innovation and settlement
of relatively sparse areas.)
The quality and success
of the management team is a deciding
factor in whether we invest,
as we build and realize value through
growth and operating improvements, not through financial engineering.
But thereafter,
factors such
as the stock chart pattern and company earnings
growth become part
of the criteria for picking which stocks to swing trade.
at 989 (observing that an «against» recommendation from ISS «overshadow [s]» other performance
factors such
as the
growth of CEO pay); id.
Critics
of the Modi government have often used lack
of job
growth as one
of the
factors to criticise the...
Those data are namely 1) the recent rally in stocks, 2) the recent improvement in the ISM (formerly NAPM) surveys, and 3) the substantial string
of Fed easings «in the pipeline», which have accelerated
growth in broad money such
as M2, and 4) the likelihood that inventories will stabilize, taking away the biggest negative
factor currently pressuring GDP lower.
Meanwhile, some
of the external
factors that helped to drive profit
growth in the past three decades, such
as global labor arbitrage and falling interest rates, are reaching their limits.
The disappointing performance
of business investment to date could reflect more sustained structural
factors, such
as slowing labour force
growth, low productivity
growth and regulatory obstacles.
While the majority
of respondents in the winter survey still anticipate slow
growth, more firms than in the autumn survey expect strong
growth, citing the outcome
of the US election
as one
of the underpinning
factors.
There are potential areas
of growth, including increasing the tie ratio between games and consoles, which will improve
as platform libraries (games) grow, and accessory sales, which will depend on a myriad
of factors, including the continued push towards new market opportunities (e.g., toy - based games).
But, judging from recent messaging, Fed policymakers have yet to see compelling evidence
of an acceleration in overall activity, viewing
growth as set to remain at around trend rates, and are reluctant to
factor in any significant impact from the Trump administration's future policies.
As a result of these factors, Pioneer expects production growth to come in at the low end of its 15 % - to - 18 % guidance range for the year, while oil as a percentage of total production will be 58 % instead of the 62 % it expecte
As a result
of these
factors, Pioneer expects production
growth to come in at the low end
of its 15 % - to - 18 % guidance range for the year, while oil
as a percentage of total production will be 58 % instead of the 62 % it expecte
as a percentage
of total production will be 58 % instead
of the 62 % it expected.
In contrast, export volumes decreased over this period, despite strong global demand,
as capacity and infrastructure constraints and supply disruptions restricted
growth; such supply - side
factors have hampered exports for a number
of years, with resource export volumes now lower than during 2000 (see the chapter entitled «Australia's Resource Exports — Recent Trends and Prospects» in this Statement).
Factor in what might be high - single - digit business
growth over the next year,
as well
as what's currently a yield
of just over 2.25 %, and you could easily make a case for what might be a total return
of ~ 25 % for 2018.
The International Monetary Fund cut its global economic
growth forecast for 2016 on Tuesday
as it expects a number
of factors to weigh on world economies.
There's no shortage
of factors to weigh
as the Fed stands ready to hike interest rates faster than anticipated on worrying signs
of inflation
growth and the tap
of foreign liquidity supporting 10 - year Treasuries could dry up
as central banks in Europe and Asia curb their quantitative easing programs.
A variety
of factors — such
as the outlook for economic
growth and inflation, supply and demand for credit, market sentiment, and other
factors beyond the Fed's control — impact long - term rates.
As we look to the next leg
of this bull market, the most important
factor is the continued strength in earnings
growth.
One
of the
factors we look at is DPS
growth over the past three years,
as this suggests long - term sustainability.
We caution you that these statements are not guarantees
of future performance and are subject to numerous risks and uncertainties, including volatility in the economy and the credit markets, supply and demand changes for vacation ownership and residential products, competitive conditions; the availability
of capital to finance
growth, and other matters referred to under the heading «Risk
Factors» contained in the Information Statement filed
as an exhibit to our Annual Report on Form 10 - K for the year ended December 30, 2011 filed with the U.S. Securities and Exchange Commission (the «SEC») and in subsequent SEC filings, any
of which could cause actual results to differ materially from those expressed in or implied in this presentation.
Now, with that out
of the way, the more important
factor is what the Bank sees
as the trajectory
of economic
growth for Canada, because that will be fixed income investors» guide for how it will react to disappointment or surprises along the way.
There have been periods
of time when exposure
factors can, and have underperformed the market, such
as dividend
growth stocks over the last four years.
The trigger should also be large enough to ultimately cover any revenue that does not end up materializing
as a result
of economic
growth or other
factors.
Ultimately, how you finance the
growth of your business will come down to a range
of factors, and will likely change
as your business evolves.
While profits
of most
of the listed companies in the S&P 500 Index showed robust
growth, there are a number
of underlying
factors such
as wage
growth, consumer spending, auto and home sales that need to expand significantly.
Some
of this
growth may be due to the expected increases in residential construction, a
factor that IBIS World says directly relates to demands in plumbing and HVAC — great news for the 117,776 businesses in these industries
as of October 2017.
Twitter's management touts its user
growth as a driving
factor of its ability to succeed.
Our appraisal
of what any company is worth is based on quantitative
factors like its
growth rate and returns on incremental capital
as well
as on qualitative
factors like its management quality and stability
of cash flows.
And while equity markets have been performing well this year, there are numerous potential risk
factors that could cause a sharp correction in the equity markets, such
as the U.S. election, sluggish global economic
growth and the future
of Europe given the «Brexit» situation.
The pace
of growth moderated in early 2003, however, in line with the easing in the rate
of growth of domestic spending and the dropping - out
of one - off
factors such
as large purchases
of civil aircraft.
The IMF cut its global economic
growth forecast for 2016
as it expects a number
of factors to weigh on world economies.
Some reports, such
as the Open Philanthropy Project's Animal Product Alternatives report and Van der Weele & Tramper (2014) suggest it is unlikely that cultured meats will become cost - competitive with conventional meat.98, 99 One important contributing
factor in this conclusion, which is cited in these reports, is the minimum costs
of the
growth medium necessary for culturing the desired cells.
The general U.S. market may tank due to a variety
of factors, such
as a combination
of international and domestic events, from reports
of high speculation in real estate markets to poor economic
growth and growing debt.
Overall, the IMF's prediction for global
growth of 3.1 % in 2016 remained subdued, with the institution citing the uncertainty created by the United Kingdom's decision to leave the European Union (EU) and slower - than - expected US
growth as restraining
factors since its last set
of forecasts in April.
The importance
of the financial sector in supporting an efficient allocation
of resources in regards to the economic
growth factors is recognizable
as economies develop.