Studies conducted that year revealed that 75 percent
of ovarian tumors studied contained talc particles.
Not exact matches
«Nonetheless, the proof
of concept
studies we have obtained thus far are extremely encouraging, and we are confident that with proper support and efforts we could translate our findings into experimental therapeutics for a variety
of solid
tumors that are driven by EphA2 overexpression, including breast, lung, prostate, pancreatic, and
ovarian cancers,» said Pellecchia, who serves as the founding director
of the Center for Molecular and Translational Medicine at UCR.
Chemotherapy drugs designed to kill
tumors may actually encourage
ovarian cancer by stimulating the growth
of cells that give rise to the malignancy, a new
study finds.
In an earlier Penn Medicine
study, 38 percent
of all patients (and 46 percent
of females with the condition) were found to have a
tumor, most commonly it was an
ovarian tumor.
The
study published in Cancer Cell shows that exosomes from
tumor cells
of breast cancer (and other
tumor types such as
ovarian and endometrial) are different in size and composition than those
of healthy cells.
Razqallah Hakem, a cancer biologist at the University
of Toronto in Ontario, and his colleagues normally
study a
tumor suppressor called BRCA1, variants
of which put women at high risk
of breast and
ovarian cancer.
The researchers found that these immune system pathways were suppressed in a large number
of primary
tumors — roughly 50 percent
of ovarian cancers
studied, 40 percent
of colorectal cancers and 30 percent
of breast cancers.
The team's recent
study in mice has found that the treatment reduced the mass
of ovarian cancer
tumors and was more effective at suppressing
tumor growth than chemotherapy.
«This
study also adds greater understanding
of tumor - infiltrating lymphocytes and their influence on the causes and progression
of ovarian cancer.
Heeke says the
study would be open to people whose
tumors have evidence
of HRD like those found in this
study, which includes bladder, breast, cervix, liver and bile duct, colorectal, endometrial, gastric / esophageal, head & neck, kidney, neuroendocrine, lung,
ovarian, pancreas, prostate, sarcoma, and thyroid cancers, as well as gastrointestinal stromal
tumors, glioma, melanoma and unknown primary cancers.
One
study showed that
ovarian tumors produce a signaling molecule that serves to attract regulatory T cells, a subclass
of adaptive immune cells responsible for quieting other T cells.
The
study also suggests how
ovarian cancer treatments can be tailored based on the metabolic profile
of a particular
tumor.
Now, results
of a
study of nine women suggest that the genomic roots
of many
ovarian tumors may indeed arise in the fallopian tubes, potentially providing insights into the origin
of ovarian cancer and suggesting new ways for prevention and intervention
of this disease.
Led by Ludwig Lausanne investigator Alexandre Harari and George Coukos, director
of the Ludwig Institute for Cancer Research, Lausanne, the
study shows that
ovarian tumors harbor highly reactive killer T cells — which kill infected and cancerous cells — and demonstrates how they can be identified and selectively grown for use in personalized, cell - based immunotherapies.
Women with Stage III
ovarian cancer given a combination
of intravenous and intraperitoneal chemotherapy following surgical debulking
of tumor had a median survival nearly 16 months longer than women who received IV chemotherapy alone, according to a
study published conducted by the Gynecologic Oncology Group (GOG), a National Cancer Institute - supported research network, in the January 5, 2006 issue
of the New England Journal
of Medicine.
The authors
studied a standard panel
of 60 established human
tumor cell lines representing nine different human cancers, as well as several specimens
of human primary
ovarian cancer.
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The
study evaluated the efficacy and safety
of cabozantinib compared to placebo in 9 different solid
tumor types including breast, lung,
ovarian, and prostate.
These interests grew from
studies of paraneoplastic neurologic disorders (PNDs), a group
of diseases thought to arise when
tumors — typically breast,
ovarian, or lung cancers — start making proteins normally only made by the brain.
Alexandra Snyder, MD, is a translational physician scientist at Memorial Sloan Kettering Cancer Center (MSKCC) who specializes in the
study of tumor genetics and response to checkpoint blockade immunotherapy in solid
tumors, with a particular focus on
ovarian cancer.
«Visualizing how cancer cells interact with a
tumor microenvironment that accurately reflects the complex biology
of ovarian cancer should help us understand the mechanisms underlying metastatic progression as well as identify new therapeutics that can inhibit this process,» said clinical gynecologic oncologist Ernst Lengyel, MD, PhD, senior author
of the
study and a professor
of obstetrics and gynecology at the University
of Chicago.
The chronically stressed mice had decreased immune function and experienced
tumor development significantly earlier than the non-stressed mice.16 Other mouse
studies of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.
They even found talcum powder particles in the
tumors of the
ovarian cancer patients they
studied.