Sentences with phrase «of their cell proliferation»

«I think that we've produced a 3 - D microenvironment which is much more like that found in vivo for growing embryoid body, which explains the higher levels of cell proliferation.»

In the case of planarians, the gene egr - 4 seems to perform an early control of cell proliferation as a response to amputation, and be involved later in the early differentiation of brain during regeneration.

However, they are expensive and have issues such as being prone to deterioration in terms of their cell proliferation effect.

The rate of cell proliferation varied only slightly between the different endothelial cell lines (Fig. 3) ⇓.

We use the fission yeast, Schizosaccharomyces pombe, to study the dynamic changes and plasticity of gene expression programs as a function of cell proliferation, quiescence and ageing, and the effect of various genetic and environmental perturbations.

The region is a busy hub of cell proliferation.

In addition to the modulation of cell proliferation, p21waf1 / cip1 is also involved in the regulation of apoptosis, differentiation, and stress response (11).

Mutations in the PTEN gene prevent the proper regulation of cell proliferation.

The origins of many of these and other genes specific to animal processes such as cell adhesion, and social control of cell proliferation, death and differentiation can be traced to genomic events (gene birth, subfamily expansions, intron gain / loss, and so on) that occurred in the lineage that led to the metazoan ancestor, after animals diverged from their unicellular «cousins».

These biochemical mechanisms influence four different actions, which are cellular apoptosis, the inhibition of cell proliferation, the suppression of cytokine production and the reduction of white blood cells or leukocytes.

We observe that a stress of 10 kPa is sufficient to drastically reduce growth by inhibition of cell proliferation mainly in the core of the spheroid.

New data and research approaches have created opportunities for researchers to study in detail many aspects of cancer biology, including how the normal biological programs of cell proliferation and death are altered during cancer and how the immune system responds to tumors.

Inhibition of cell proliferation (B) of MCF7, MCF7 / HER2, or BT474 cells treated for 6 days with F3 - IgG, trastuzumab, or isotype control antibody.

Because Wnt signaling is involved in the regulation of proliferation and apoptosis, and miR - 150 is reported to regulate proliferation of breast cancer cells, we think that the functions of these microRNAs include the regulation of cell proliferation and apoptosis.

Consequently, the normal rate of cell proliferation would have been decreased during protein deprivation, which is similar to the retardation of brain cell growth of young malnourished animals described by Winick and Rosso (18).

«the normal rate of cell proliferation would have been decreased during protein deprivation, which is similar to the retardation of brain cell growth of young malnourished animals.

«[T] he normal rate of cell proliferation would have been decreased during protein deprivation, which is similar to the retardation of brain cell growth of young malnourished animals.

Inhibition of cell proliferation and in vitro markers of angiogenesis by indole -3-carbinol, a major indole metabolite present in cruciferous vegetables.

Not exact matches

The proliferation of cell phones and ecommerce has disrupted traditional delivery services in markets around the world, particularly in emerging and frontier economies.

High dosages of reb A fed to rats reduced sperm production and increased cell proliferation in their testicles; however, another study using rats and humans demonstrated lack of reproductive toxicity.

During early pregnancy, hormones including progesterone, produced by the placenta, which is fetal tissue, cause proliferation of the milk producing cells within a mother's breasts.

Proliferation of the distal portions of the ducts results in the formation of multiple alveoli (which contain lactocytes — cells that secrete milk).

Transient Silencing of 14 -3-3sigma promotes proliferation of p63 - positive progenitor cells isolated from human breastmilk in mammary epithelial cell culture.

Secretion of the hormones estrogen and progesterone set the stage for dramatic changes that take place in the breast during pregnancy: a massive proliferation of mammary epithelial cells, and the formation of thousands of ductal structures, which support milk production and transport during lactation.

One factor behind this evolution is that fact that the internet's main rivals as communications channels (general - audience broadcast advertising, phonebanking / robocalls and direct mail) are all gradually losing effectiveness as a result of a variety of factors including increased competition for viewer attention, cable channel proliferation, cell phone ubiquity, and overall junk - mail resistance.

The researchers used a drug called clorgyline to inhibit the activity of the MAOA enzyme; the drug disrupted the signaling system that led to cancer cell invasion and proliferation.

«It provides great insight into how cancer cells can select for elements of DNA that help their proliferation and survival,» he says.

E2F1 is known to contribute to the development of cancer by promoting cancer cell proliferation; however, this is the first time that E2F1 has been shown to contribute to metastasis of lung cancer.

One of the team's new biosensors is made from a nanoplasmonic material that is able to accommodate a large number of cells on a single substrate and to monitor cell proliferation, a fundamental process involving cell growth and division, in real time.

Unlike the differential effect on Treg cell proliferation following PD - L1 blockage, the researchers observed an increase in the proliferation of killer T cells from all HIV study groups, regardless of their viral load.

IPS cells have high proliferation rates and are not yet specialized to perform functions, such as being part of the skin.

In the placenta, RDGs have been found working in pathways associated with many of the tools of invasion: immune suppression, blood vessel growth, cell proliferation, and inflammation.

Schematic illustration of cells (blue mountain - like shapes) on top of nanoscale mushroom - like structures with silicone dioxide stems and gold caps, which have the potential to detect cell proliferation in real - time.

The researchers were able to inhibit proliferation of the cells in vitro using the FGFR inhibitors PD173074 and pazopanib.

What if proliferation is the norm for cells — and a very different theory of cancers» cause is waiting in the wings?

Tasoglu and Demirci also demonstrated that micro-robotic construction of cell - encapsulating hydrogels can be performed without affecting cell vitality and proliferation.

The process involves the reversion of delta cells (which produce somatostatin, another pancreatic hormone) to a precursor - like cell state, with proliferation and later reconstitution of the populations of beta and delta cells.

In cell culture, high expression levels of GPR161 induced proliferation of mammary epithelial cells, disrupted the acinar structures formed by these cells, and enhanced their invasive capacity.

We will then seek to develop the most promising of these into novel drugs for cancers, such as those of the breast, where up - regulation of this c - FLIP is believed to be important in cancer cell proliferation.»

The underlying mechanism involves the activation of the immune system, resulting in local inflammation and proliferation of skin cells.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

They were able to block proliferation of several cancer stem cell lines.

Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal stem cells that have the potential to become multiple different kinds of cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.

Specifically, they boosted the survival and proliferation of the cells that make up the lining of the colon.

But the researchers also found that the new molecule intervened directly in the growth of the cancer itself, inhibiting a protein that controls the division and proliferation of malignant cells.

By using «gemcitabine» chemotherapy to target cancer cells, and a form of vitamin A to target the surrounding stromal cells, the combined approach led to a reduction in cancer cell proliferation and invasion.

A COMPOUND that slows the proliferation of triple - negative breast cancer cells in lab tests could lead to the first drugs to target this aggressive type of tumour.

The release of several signals by skin cells that are dying contributes to the creation and spreading of the chronic immune response and hyper - proliferation and irregular differentiation of epidermis,» says Joan Manils, first author of the study and member of the mentioned department and post-doctorate researcher at the Trinity Biomedical Sciences Institute (Ireland).

What if proliferation is the norm for cells — and a very different theory of cancers» cause is waiting in the wings, ask Carlos Sonnenschein and Ana M. Soto

Directly or indirectly, Holick points out, «the active form of vitamin D controls up to 200 different genes,» including ones responsible for cell proliferation, differentiation, and death.