Sentences with phrase «of therapeutic»

Data from a new study on how antibodies are developed in humans can be utilized to improve the development of therapeutic antibodies for treating human diseases.

In fact, the FDA has recommended that newer technologies be employed as soon they become available, to reduce the possibility of very serious off - target effects of therapeutic antibodies that bind to antigens in non-target tissues.

«We are now able to make biochemical measurements that will help us objectively assess functional changes in children and adults with SMA, and, hopefully, detect early signals of therapeutic success in new drug trials for this devastating disease.»

A phase 2 study of the therapeutic vaccine is currently underway in other centers in patients with recurrent disease to see if it can help extend 12 - month survival.

Langmuir 29 (35), 10973 - 10979 (2013) «Reduced limbic metabolism and fronto - cortical volume in rats vulnerable to alcohol addiction» A. Gozzi, F. Agosta, M. Massi, R. Ciccocioppo, and A. Bifone NeuroImage 69, 112 - 119 (2013) «Polymeric nanocarriers for controlled and enhanced delivery of therapeutic agents to the CNS» M. Gagliardi, G. Bardi and A. Bifone Theraputic Delivery, 3 (7), 875 — 887 (2012), doi: 10.4155 / TDE.12.55 «Neuromapping techniques in drug discovery: pharmacological MRI for the assessment of novel antipsychotics» A. Bifone and A. Gozzi Expert Opinions in Drug Discovery, 7 (11): 1071 - 82 (2012) «Neuroimaging evidence of altered fronto - cortical and striatal function after prolonged self - administration in the rat»

A number of therapeutic efforts were employed for the disease in Asia and in Canada; however, no treatment of clear value was identified.

Ease of therapeutic attack — especially the probability of finding a suitable molecule for proof - of - concept pharmacological studies in a timely manner

There are a wide range of therapeutic treatments [1], although none have shown any more than modest clinical effects [2].

The phenotyping platforms of PHENOMIN - ICS area, adapted to study genetically modified mouse models, can also be used for preclinical studies, including the validation of therapeutic targets, as well as pharmaceutical and toxicological studies in mice.

In the following weeks I hope to be able to adjust the quality of my therapeutic sessions, to find enough arguments for treatment concepts and to study the interdisciplinary work in my department in Germany.

Career Goals: Peipei is passionately building up her career as professional research investigator to continue unraveling the mystery of aberrant myelopoiesis with the goal of developing new generation of therapeutic method for cancer & cardiovascular disease.

Radiation - induced pulmonary fibrosis — tissue scarring that can permanently impair lung function — limits the delivery of therapeutic radiation doses to non-small cell lung cancer.

Mike currently serves as Chief Development Officer for Silvergate, and was previously instrumental in the worldwide development and regulatory approval of products spanning a broad range of therapeutic categories at Beckloff Associates.

The comprehensive information presented for each cell therapy includes: an overview of the therapy, a list of therapeutic cells utilized in the specific treatment, mode and regimen of cell delivery, mechanism of action, formulation, in vitro data, animal models, preclinical data and related clinical trials.

«Our findings suggest that apoE4 inhibits the development of newborn neurons by impairing specific signaling pathways and that boosting these pathways with drugs may be of therapeutic benefit,» said Dr. Huang.

In January 2014, while finishing her thesis, she started a Postdoctoral fellowship in the lab of Prof Erik SG Stroes at the Department of Experimental Vascular Medicine of the AMC studying macrophage - targeted nano - delivery of therapeutic compounds to the atherosclerotic plaque.

The Institute's phenotyping platforms are adapted for the study of mutant mice and genetic reference populations but can also be used for preclinical studies including the validation of therapeutic targets as well as pharmacological and toxicological studies in the mouse.

[32 - 34] And recently, emerging evidence has pointed to an important indirect role played by senescent cells (specifically, senescent glial cells) in PD, contributing to the dysfunctional neuroinflammation and SN DA neuron loss in PD, [35] and researchers are now reporting the salutary effects of their therapeutic clearance.

In the 1980s, Dr. Kaufman's experience with gene transfer and engineering led him to become a founding scientist at Genetics Institute Inc., where he engineered mammalian cells for high - level expression of therapeutic proteins, such as clotting factors that are now used to treat individuals with hemophilia.

Therefore, in order to increase the efficacy of therapeutic treatments, combination therapies are commonly administered.

By delivering mRNA therapeutics intravenously (IV), we can potentially stimulate production of therapeutic proteins in the liver in ways that can not be achieved with other technologies.

The field of neurology continues to lag behind those of other disciplines when it comes to the range and efficacy of therapeutic strategies.

Madsen, Hirschberg, and their research team are exploring a small solution to this big problem: employing macrophages, the aforementioned, material - ingesting white blood cells, to transport nano - sized particles of therapeutic gold to surgical resection sites.

By delivering mRNA drugs via IV to the liver, and directing liver cells to express functional proteins, Moderna can potentially stimulate production of therapeutic proteins in ways that can not be achieved with other current technologies.

Cook Regentec's starting range of products includes cellular growth media, solutions for cryopreservation, and medical devices for the delivery of therapeutic agents.

Third, the tumour phenotype of mice with genetic deletion of Tie2 in pericytes warrants some careful reconsideration of the concepts of therapeutic angiopoietin targeting to interfere with tumour angiogenesis and for the future design of anti-angiogenic combination therapies.

For many medications, inherited differences in patients» ability to metabolize, transport, and eliminate drugs and in the characteristics of drug targets and receptors are significant determinants of therapeutic or adverse effects of medications.

Considering the vast population of patients with these diseases, the development of CXCR4 antagonists is of therapeutic as well as economic importance.

Dr. Thinle Chodon was recruited in September 2013 as an Assistant Member and Associate Director of the Therapeutic Cell Production Facility (TCPF) at the Center For Immunotherapy (CFI).

He reviews the history of the use of therapeutic brain surgery in HD, which has been pretty limited.

CAMBRIDGE, Mass., July 31, 2013 — Moderna Therapeutics, the pioneering company developing messenger RNA therapeutics ™, a revolutionary new treatment modality to enable the in vivo production of therapeutic proteins, announced today that Joseph Bolen, Ph.D., joined Moderna as its president of research and development (R&D).

A dedicated educator and mentor, Dr. Siddiqui teaches techniques of therapeutic endoscopy in courses for gastroenterologists, trainees, and nurses.

I - Stem teams are involved in collaborative networks with many research teams both academic and industrial, in programs concerning various aspects of the therapeutic use of pluripotent stem cells.

For 2018, the CIMT program committee is preparing plenary sessions from pre-clinical research to clinical development on the topics of therapeutic vaccination, cellular therapy, improving immunity, tumor microenvironment, antibodies, regulatory research and immunoguiding.

This call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to: ◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified ◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level Indeed, producing these models meets a key objective in the development of a therapeutic strategy.

INGESTEM, the national infrastructure in biology and health certified by the «Investissements d'Avenir» program and the Ile - de-France Region (DIM Biothérapies), is the first French network of therapeutic innovations based on pluripotent stem cells, human tissue engineering and their biomedical applications.

It was revealed that neonatal thymic tissue transplantation can lead to the restoration of immune function, but limited availability of tissue grafts of this organ does not allow the wide spread of this therapeutic approach and its introduction into clinical practice.

Indeed, producing these models meets a key objective in the development of a therapeutic strategy.

The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.

In fact, professed familiarity with stem cell research in the prior question turned out to be a leading indicator of actual ignorance with respect to this question of therapeutic uses.

Cell lines provides solution for manufacture of therapeutic and diagnostic protein and for applications in drug screening, pharmacological research and toxicological studies

In 2007, he joined Columbia University as a post-doc, where he developed network - based computational approaches aimed at identifying key drivers of initiation and progression of cancer, as well as mechanisms of therapeutic response and drug resistance.

Aside from highlighting the contrast properties and carrier features available in nanotechnology, the overall goals of Dr. Pham's efforts are to (i) provide microanatomical and functional imaging feedback of the therapeutic process and (ii) realize an approach for longitudinal treatment and monitoring.

The partnership is named The Learning Collaborative because this model is scalable, applicable across a wide range of therapeutic areas, and replicable by organizations committed to innovative models of collaboration.

Current pre-clinical efforts are focused on optimizing specific microbiome compositions based on functional and phylogenetic information to inform the development of therapeutic candidates.

Selectivity of the therapeutic approach is achieved by producing an enzyme called E. coli purine nucleoside phosphorylase (PNP) directly within tumor cells and using the enzyme to generate novel chemotherapy in the tumor mass itself.

Thank to a 3 years support provided by CRI, we were able to make the first demonstration of this therapeutic strategy in experimental animals.

The Caribou technology platform and our scientific capabilities can improve these cell systems to yield larger quantities and higher qualities of therapeutic biomaterials.

Affineti Biologics, Inc. is advancing its research in the development of therapeutic and diagnostic products based on new discoveries in oral biology and dental medicine.

CRI presents the Coley Award to Jeffrey V. Ravetch for his work on Fc receptors, leading to fundamental discoveries critical to improving the design of therapeutic antibodies.