Sentences with phrase «of these alleles remains»

However, most point mutations occur at low frequency, and the function of these alleles remains undefined.

Not exact matches

When people migrated out of Africa, their small numbers resulted in a bottleneck, in which they lost many alleles that remained in larger populations in Africa.

Of the remaining 61 patients, 54 had one copy of T allele and one copy of the minor G allele, and 7 patients had two copies of the G allelOf the remaining 61 patients, 54 had one copy of T allele and one copy of the minor G allele, and 7 patients had two copies of the G allelof T allele and one copy of the minor G allele, and 7 patients had two copies of the G allelof the minor G allele, and 7 patients had two copies of the G allelof the G allele.

In 15 of the brain samples, researchers found that one copy of DRD2 was producing at least 50 percent more mRNA than the other one; in the remaining brains, they discovered that both alleles produced equal amounts.

«This research is very important, but it remains to be clarified what the role of these two loci are,» says Mark Connors, an immunologist at the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, whose lab first reported that HIV - infected people who remain unharmed by the virus for many years often have the HLA - B * 5701 allele.

The results remained significant after adjusting for multiple risk factors including age, sex, race, education, and presence of an APOE ɛ 4 allele.

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

In contrast to this prediction, primary tumors with LOH at the p16 locus had a paucity of mutations in the remaining allele (Spruck et al. 1994; Cairns et al. 1994).

The genetic and phenotypic nature of the Merle locus and the merle allele (M) is such that it would not remain unnoticed in a breed and suddenly appear.

(b) In the mediation regression where both S allelic frequency and cultural value of individualism — collectivism were included as predictors of global depression prevalence across 12 nations, individualism — collectivism remained a reliable predictor (β = − 0.21, p < 0.05), and the effect of S allele frequency decreased significantly (from r (12) = − 0.51 to r (12) = − 0.03; Sobel test Z = − 1.92, p < 0.05).

It remains unclear why anxiety and mood disorders are less prevalent in East Asian relative to Western cultures, especially given that a majority of individuals living in East Asia carry the S allele of the serotonin transporter gene, which is associated in Western populations with negative affect.

It remains unclear why there exists genetic selection for S relative to L allele carriers in East Asian regions, but not other geographical regions of the world.

In the mediation regression where both S allelic frequency and cultural values of individualism — collectivism were included as predictors of global anxiety prevalence across 12 nations, individualism — collectivism remained a reliable predictor (β = − 0.24, p < 0.05), and the effect of S allele frequency decreased significantly (from r (12) = − 0.55 to r (12) = − 0.08; Sobel test Z = − 1.60, p = 0.05)(figure 3a).

Similarly, in the mediation regression where both S allelic frequency and cultural value of individualism — collectivism were included as predictors of global depression prevalence across 12 nations, individualism — collectivism remained a reliable predictor (β = − 0.23, p < 0.05), and the effect of S allele frequency decreased significantly (from r (12) = − 0.51 to r (12) = − 0.01; Sobel test Z = − 1.92, p < 0.05)(figure 3b).