Sentences with phrase «of these binding partners»

«Our data clearly showed that one of the protein receptors on white blood cells called CXCR3 brings white blood cells to the optic nerve in response to production of its binding partner CXCL10 by damaged nerve tissue,» said Zhang.

Once receptors sense the presence of these binding partners, they send out new signals that initiate other cellular processes.

In the case of switchSENSE, this is the additional information on size and conformational changes of the binding partners.

Not exact matches

When boot maker Vans signed on as a partner in the summer of 1995, Switch agreed to produce 6,000 bindings, which cost Switch $ 50 a pop.

The company is comprised of four major business units: Bound Tree Medical, Cardio Partners, Emergency Medical Products and Tri-anim Health Services.

There are also complications surrounding breakups of home - owning couples: an exiting partner will often neglect to notify the lender of the change in status and is still bound to a mortgage even if his or her name has been removed from the deed.

Ithaca Capital Partners, a real estate investment management company, is pleased to announce the execution of a binding agreement between a holding company (the «Buyer») and Caribbean Property Group (the «Seller»), for the acquisition (the «Transaction») of a portfolio of Hotel assets (the «Portfolio»).

Many classic Protestant confessions contain definitions of marriage which implicitly rule out of bounds same sex marriage (and any other permutation of partners which the human mind might invent).

I'd love to see us partner with my friends Kristen Howerton and Nish Weiseth to help care for the children and communities left in a bind because of pulled funding over this issue.

What links Trump's past willingness to use and then abandon women to his willingness to use and abandon business partners is his refusal to honor the sacredness of the ties that bind society together.

Luckily, we can enjoy each other out of bounds in our privacy, keep our hearts true, and let our imaginations out to play in private, with our partners dictating boundaries, not our neighbors.

Yes, according to Merle Weiner, a law professor at the University of Oregon, who proposes that rather than focus on marriage, the state should create a parent - partner status that would legally bind parents — married, cohabiting, living apart, romantic partners or not — with certain mandatory obligations in order to give their children what they need to thrive.

«This autumn both David Cameron and Nick Clegg should ask their parties to approve a binding agreement to fight the 2015 general election as coalition partners... If the voters choose to keep our current system of electing MPs, as I fervently hope they will, the pact would give parliamentary candidates in constituencies in seats held by a coalition party a free run against other parties.

But it would be bound to provoke tensions with the party's Conservative coalition partners, who strongly oppose reform of drugs laws.

These findings suggest that the therapeutic protein was able to interact normally with its binding partners among the USH1 molecular complex (the proteins cadherin 23, protocadherin 15, myosin VIIA and harmonin), as required for the mechanoelectrical transduction apparatus of the hair bundle to function correctly.

Interaction between the PD - 1 protein found on killer T cells and its binding partner PD - 1L is one hallmark of immune exhaustion, and interfering with this interaction a potential strategy to overcome it.

«Considering that two - thirds of the U.S. federal government hasn't even signed off on the Clean Power Plan and 13 states have already pledged to fight it, our international partners should proceed with caution before entering into a binding, unattainable deal.»

The NTNU University Museum is collaborating with several international partners to determine what factors affect the binding rate and accumulation of carbon in bogs.

To conclude, such correlated water movements could support the interaction of biomolecules like enzymes and proteins with their binding partners and play a significant role in their mutual recognition, allowing the biomolecule to select or reject certain binding partners.

It was demonstrated that the movement of water molecules in the vicinity of the protein's active centre, the so - called binding pocket, is connected to potential binding partners in the water solvent.

The authors report that when the inactive halves of DAM attached to Notch and its partners rejoined, they reactivated and allowed the marking of the bound DNA in kidney cells.

We identified c - Jun amino - terminal kinase 3 (JNK3) as a binding partner of β - arrestin 2 using a yeast two - hybrid screen and by coimmunoprecipitation from mouse brain extracts or cotransfected COS - 7 cells.

In the course of the reaction, an atom or a group of atoms bound to a molecule is exchanged by another binding partner.

Martemyanov explains that GPR158 is a so - called «orphan receptor» (which gets its name because its binding partner / partners are unknown) with a poorly understood biology and mechanism of action.

But researchers haven't been able to identify the sperm's binding partner in the layer, although their suspicions have fallen on two of the glycoproteins, ZP2 and ZP3.

Niphakis began by making probe molecules that mimic the structure of arachidonoyl lipids and capture protein - binding partners when exposed to ultraviolet light.

Of the 49 which are still administered by the Treuhand, only two are likely to stay bound to their original partners.

Eph receptors and their binding partners, the ephrins, are found on the surface of almost all cell types.

The study focused on a small subset of nuclear receptors, a large family of proteins that regulate gene expression in response to signals from various binding partners, including steroids and fats.

These data suggest that IL - 15Rα alone should not be considered merely a subunit of the trimeric IL - 15 receptor, but is likely an integral binding partner that can alter IL - 15 biological activity.

They knew that the enzyme requires oxygen to catalyze the production of methylphosphonate, so by eliminating oxygen they were able to get snapshots of the enzyme as it bound to the necessary reaction partners but before it performed the reaction.

Each of the twenty - one amino acids used by the human body has a tRNA binding partner that carries it to the ribosome where it can be incorporated at the appropriate point into a growing protein.

Our laboratory has also been investigating the role of the LIGHT receptor HVEM when its binds to a different partner, the B and T lymphocyte attenuator (BTLA).

Thus, many researchers, who have identified PTMs that are often unique signatures of a certain cancer, send us their modified proteins in the hopes that we can identify relevant binding partners.

The fusion partner, the other part of the CAR, contains the business end — it's basically the engine that activates the T cell and tells it to kill the tumor cell that it's bound to, and also makes the T cell proliferate.

We discovered STK38 as a novel binding partner of Beclin1, a key regulator of autophagy.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL - 6 corepressor.

Regulation of RNA - polymerase - II - dependent transcription by N - WASP and its nuclear - binding partners.

Using surface plasmon resonance experiments, an in vitro method for determining molecular binding partners, the researchers found that both ApoE4 and ApoE3 — an ApoE isoform associated with a lower risk of AD compared to ApoE4 — bound the SIRT1 promoter.

Recently, the combination of these two techniques has produced a new generation of experimental setups enabling the simultaneous manipulation of a biological substrate (for example an actin filament or a DNA molecule) and detection / localization of an interacting partner enzyme (for example myosin or a DNA - binding protein).

We apply computational modelling and simulation techniques to understand the hetereogeneity of the GAG component and to study structural and physical characteristics of GAGs in the context of their interaction with their biological binding - partners.

We also found that the SRC and ABL non-receptor tyrosine kinases and the SHEP1 scaffolding protein are binding partners of the Eph receptors, and we identified signaling connections between Eph receptors and integrins.

ChIP - Seq analysis of DNA methyltransferase 1 (DNMT1), which is a key epigenetic partner for DAXX repression, revealed that DNMT1 binding was restricted to a small number of DAXX sites.

We are currently investigating the details of the signaling cascades involved in these phenomena, as well as attempting to identify cytoplasmic binding partners for NG2 which may serve as effector molecules for activation of downstream signaling events.

For example, our past work showed that two conserved tyrosine phosphorylation sites in the juxtamembrane segment of the Eph receptors not only mediate association with binding partners but also regulate receptor kinase activity.

This was followed by the discovery of a second partner for PD - 1 — the molecule PD - L2 — which also appeared to tame T - cell activity by binding to PD - 1.

One mutant could still bind to its protein - binding partner, a CDK, but not to wildtype p21 or p27, suggesting that the mutation resulted in an always - active complex that drove constant cell division — a hallmark of malignant cells.

Many of Myst2 and Niam binding partners are required for correct embryonic development, implicating Myst2 and Niam in the cooperative regulation of this process and suggesting a novel role for Niam in embryonic biology.

One important outcome of these studies is the observation that Oct4 and its protein binding partners form complex auto - regulatory circuits in which Oct4, Sox2, and Nanog proteins bind to each other's promoters.