Sentences with phrase «of tissue architecture»

Such samples, commonly referred to as FFPE, preserve the integrity of the tissue architecture of the original tumor, allowing the researchers to study the spatial differences in protein expression.

The point of this paper is we should not overlook the huge influence of the tissue architecture, the tissue environment, the tissue composition.

Gartner's group plans to use the technique to investigate what cellular or structural changes in mammary glands can lead to the breakdown of tissue architecture associated with tumors that metastasize, invading other parts of the body and threatening the life of the patient.

Not exact matches

«Ideally, the architecture of the scaffold should mimic that of the native tissue to be repaired,» says Wei Shen, a postdoctoral research associate also in the department.

«Using a new layer - by - layer fabrication process, we created a microfluidic environment in which TEER - measuring electrodes are integral components of the chip architecture and are positioned as close as possible to the tissues grown in one or both of two parallel running channels,» said Olivier Henry, Ph.D., a Wyss Institute Staff Engineer who was the driving force behind the new Organ Chip designs.

Both the tissue architecture and the air flow change dramatically along the 24 generations of the lung airway, from the large bronchus down to the alveoli.

Much work remains in optimizing how faithfully the bits of tissue reproduce normal brain function and architecture, Panchision says.

Ultimately, MICrONS aims to map every neuron and synaptic connection within a 1 - cubic - millimeter chunk of tissue from the mouse visual cortex, and use those detailed brain connection maps to design computer architectures able to perform tasks that are easy for a brain but out of reach for artificial intelligence.

We have been fortunate to work in collaboration with the pharmaceutical company Pharmaxis, which is designing novel and highly selective small molecules that will allow the establishment of normal tissue architecture after wound repair.»

Tissue specific architecture of nutrient dependent responses in D. melanogaster.

They printed 3D tissue constructs with a variety of architectures, culminating in an intricately patterned construct containing blood vessels and three different types of cells — a structure approaching the complexity of solid tissues.

Scientists could also use the printed tissue constructs to shed light on activities of living tissue that require complex architecture, such as wound healing, blood vessel growth, or tumor development.

Fused deposition modeling of novel scaffold architectures for tissue engineering applications.

With the recent development of transgenic mouse models, which allow labelling and manipulation of specific cell types, more and more emphasis has been placed on the tissue scale: How does the collective behavior of many cells gives rise to the architecture that is characteristic for given kind of tissue?

In fact, an important feature in understanding the development of a tissue disease is the relationship between morphological features such as architecture, shape, symmetry, and function.

In addition to halting growth, senescent cells secrete abnormally large amounts of proteins that inflame the immune system and degrade the normal supporting tissue architecture.

«This latest work extends the capabilities of our multi-material bioprinting platform to thick human tissues, bringing us one step closer to creating architectures for tissue repair and regeneration,» says Jennifer A. Lewis, the Hansörg Wyss Professor of Biologically Inspired Engineering, the senior author on the study and a Wyss Core Faculty member.

Among them, there are genetic instability (mainly aneuploidy, a defect in chromosome number), defects in the symmetry of cell division (important for cell fate specification and tissue architecture) and impaired ciliogenesis.

In vivo studies reveal an increased stiffness and different architecture of tumor tissue when compared to its healthy counterparts.

To characterize the tissue architecture associated to dysfunctional states of the immune system in cancer settings, we make use of both confocal fluorescent microscopy and multiplexed secondary ion beam imaging.

These developments in microscopy coupled with techniques that make tissues transparent are enabling microscopes to visualize the cellular architecture of whole tissues in 3D with unprecedented detail.

Furthermore, de-regulation of their functions is deleterious to tissue architecture and can result in the sorting of somatic rounded clones minimizing their contact with surrounding wild - type (wt) cells.

These grafts showed preservation of the muscle architecture and lack of mononuclear cell infiltration in the syngeneic and tolerant grafts, but massive tissue destruction in the acutely rejected control grafts.

We have demonstrated that the regulatory regions of housekeeping and tissue specific genes have differential chromatin architecture with respect to S / MAR binding, nucleosome positioning potential and repetitive sequences.

Upon injury, the regeneration of the adult axolotl brain rebuilds neuronal diversity, but alters the original long - distance circuitry and tissue architecture.

The accrual of body fat, when food was plenty in the summer, rendered our ancestors [and today's contemporaries who still carry the (epi) genetic architecture that predisposes them] insulin resistant, which facilitated survival in the winter by hampering the uptake of scarce carbohydrates in peripheral tissues, thereby leaving these carbohydrates for combustion by the brain.

Nolan likes himself a puzzle or, in this case, a maze: the labyrinth of brain tissue that is the architecture of our minds.

Although radiographs do not give representation of the attachment of the gum tissue, they do reveal changes in the bone and root architecture.

The imaging of soft tissue is remarkable with our digital ultrasound machine and the visualization of organ architecture provides important information to your pet's doctor.

Chronic hepatitis in dogs, also called inflammatory canine hepatic disease, refers to a syndrome in which death of hepatic cells (hepatocellular necrosis) has occurred and is associated with a chronic inflammatory process which typically progresses to liver fibrosis (replacement of hepatic tissue with fibrous tissue) and cirrhosis (progressive derangement of the liver architecture and function).

Despite these limitations, the available tissues still provided valuable information about changes in retinal architecture in advanced disease which may contribute to a better understanding of the etiopathogenesis.