Sentences with phrase «of transcription factor»

A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1

Curcumin inhibits activation of the transcription factor NF - kB, [5] which plays an important part in the regulation of the immune response to infection.

Functional Characterization of Transcription Factor Motifs Using Cross-species Comparison across Large Evolutionary Distances.

Yang L, Zhou T, Dror I, Mathelier A, Wasserman WW, Gordân R, Rohs R. TFBSshape: a motif database for DNA shape features of transcription factor binding sites.

This in turn suggests that stoichiometric control of transcription factor levels may provide robustness to this system.

Portales - Casamar E, Thongjuea S, Kwon AT, Arenillas D, Zhao X, Valen E, Yusuf D, Lenhard B, Wasserman WW, Sandelin A. JASPAR 2010: the greatly expanded open - access database of transcription factor binding profiles.

Our work indicates that only a small fraction of the population resides at the top of the hierarchy, that lineage priming (co-expression of stem cell and lineage specific genes) characterizes pluripotent stem cell populations, and that extrinsic signaling pathways are upstream of transcription factor networks that control pluripotency.

ChIP - Seq (ChIP followed by deep sequencing of DNA) is an extension of ChIP technology to determine the chromatin enrichment of a transcription factor on a genome - wide scale.

Through this mechanism, it would be possible for a cell to couple extracellular cues to maintenance of pluripotency through direct regulation of transcription factor activity, and to fine - tune gene expression as the extracellular environment dictates.

The next generation of transcription factor binding site prediction.

Drosophila DNase I footprint database: a systematic genome annotation of transcription factor binding sites in the fruitfly, Drosophila melanogaster C.M. Bergman, J.W. Carlson, and S.E. Celniker Bioinformatics (2005) 21 (8): 1747 - 1749 Download entire paper in pdf format

Computational identification of developmental enhancers: conservation and function of transcription factor binding - site clusters in Drosophila melanogaster and Drosophila pseudoobscura.

Cis - acting variants lead to local coordination of transcription factor occupancies that decay with distance; distal coordination is also observed and may be modulated by long - range chromatin contacts.

For this latest study, published today (August 6) in Cell Stem Cell, Deng's team screened for compounds that would promote the efficiency of a transcription factor involved in neuronal conversion.

JASPAR 2014: an extensively expanded and updated open - access database of transcription factor binding profiles.

Using our own data and publically available data from array comparative genomic hybridization (aCGH), we identified a minimal deletion for the cardiomyopathy associated with del1p36 that included only the terminal 14 exons of the transcription factor PRDM16 (PR domain containing 16), a gene that had previously been shown to direct brown fat determination and differentiation.

Developmental expression of transcription factor genes in a demosponge: insights into the origin of metazoan multicellularity.

Variant of transcription factor 7 - like 2 (TCF7L2) gene confers risk of type 2 diabetes.

This allows faster, more reproducible genome wide identification of transcription factor binding sites and specific DNA associated protein modifications.

Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a signal transduction pathway that appears to involve an amino acid sensing GPR [37].

These include the early duplication of transcription factor families such as homeodomains and basic helix — loop — helix domains13, 14,27.

2017-11-13 - New publication JASPAR 2018: update of the open - access database of transcription factor binding profiles and its web framework.

Cells that express high levels of the transcription factor myc up - regulate glutaminase expression more than 10-fold [105].

Repression of the transcription factor Bach2 contributes to predisposition of IgG1 memory B cells toward plasma cell differentiation.

May 25, 2000 Different levels of transcription factor coax immune cell progenitors down different developmental pathways Researchers from the University of Chicago provide evidence that varying levels of a single transcription factor can determine the fates of developing cells.

Of note, the technique employed allowed the authors to visualize the stage - specific formation and disassembly of transcription factor interaction hubs during the reprogramming process

The investigators previously showed that loss of the transcription factor Nrf2 increases susceptibility to pulmonary fibrosis.

In particular, we are interested in the role of transcription factor interactions for the regulation of pluripotentcy in embryonic (ES) and induced pluripotent stem (iPS) cells.

Quantitative fine - tuning of photoreceptor cis - regulatory elements through affinity modulation of transcription factor binding sites.

We are particularly interested in the role of the transcription factor Nanog, which we isolated through a functional screen for molecules capable of directing ES cell self - renewal in the absence of the otherwise obligatory LIF signal.

Extracellular Acidosis Stimulates NHE2 Expression through Activation of Transcription Factor Egr - 1 in the Intestinal Epithelial Cells.

Dipeptidyl peptidase - 4 inhibition in diabetic rats leads to activation of the transcription factor CREB in β - cells.

Cytokine - mediated down - regulation of the transcription factor cAMP - response element - binding protein in pancreatic β - cells.

«We found that insulin signaling can initiate the binding of this transcription factor with PLK - 1 and CENP - A, in both mouse and human beta cells,» Kulkarni says.

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF - 3 and CBP / p300.

Frank Mercurio and Anjana Rao report the cloning of the IκB kinases IKK - 1 and IKK - 2, the essential upstream regulators of the transcription factor NFκB.

Richard Flavell demonstrates the role of the transcription factor GATA3 / STAT6 in driving the generation of Th2 type CD4 + T cells.

Notably, in neurogenin - 2 transduced astrocytes we can see a similar sequence of transcription factor expression.

The repressor proteins, which are predicted to have PB1 domains identical to that of the ARF transcription factor, then stick to one or the other side of the transcription factor's PB1 domain, preventing it from doing its job.

Cortical neurogliaform cells come from this region that borders the third ventricle (middle, in black), marked by the expression of the transcription factor HMX3 (in red).

We have suggested that this subtype of interneuron is defined by the expression of this transcription factor,» explains Mathieu Niquille, a researcher in the Department of Psychiatry at UNIGE's Faculty of Medicine.

We combined a behavioral test for magnetic compass orientation in mole rats and immunocytochemical visualization of the transcription factor c - Fos as a marker of neuronal activity.

Previously, in the region that controls the function of the transcription factor that promotes differentiation from ES cells to a specific cell type, bivalent modifications of histones such as the accelerator and brake histone marks for transcription were thought to have coexisted.

Upon discovery of the transcription factor SUSIBA2, for SUgar SIgnaling in BArley 2, further investigation revealed it was a type known as a master regulator.

The team generated a profile of open and closed areas in eight stages of T - cell development and found an abundance of the transcription factor TCF - 1 at regions along the genome that were open at the earliest stages of development.

Each type of transcription factor recognizes and binds to a certain sequence of DNA.

That's why the accelerated recovery from injury after deletion of the transcription factor in reactive astrocytes was unexpected,» he said.

The goal of this research is to provide clinicians and researchers with useful information on the function of transcription factor pathways in immunophenotypically defined populations.

Researchers found an indispensable role of the transcription factor in arresting plant growth under stressful conditions.

The activation dynamics of the transcription factor NF - κB exhibit damped oscillatory behavior when cells are stimulated by tumor necrosis factor — α (TNFα) but stable behavior when stimulated by lipopolysaccharide (LPS).