Sentences with phrase «of transgenic animal models»
Although further refinement and testing is needed, Dr. Burgess said the new techniques have the potential to speed the production of many different types of transgenic animal models that will shed new light on human development and disease.
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Known as a triple transgenic model, the animals develop three key characteristics of the disease: memory impairment, amyloid plagues, and neurofibrillary tangles.
The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.
Dean LaFerla has several research interests, including the molecular biology of Alzheimer's disease and other neurodegenerative disorders, presenilins and calcium signaling, learning and memory, and transgenic and genetically modified animal models.
His lab develops isogenic human pluripotent stem cells and transgenic animals to model disease, with the goal of delineating novel approaches to influence outcomes for Huntington disease (HD) and Fragile X Syndrome (FXS), the most common genetic causes of dementia and intellectual disability, respectively.
We are organizing joint meeting with our colleagues from Masaryk University in Brno dedicated to current progress in transgenic technologies in research application, animal models of diseases and Wnt signalling.
Given the lack of definitive AD biomarkers in humans, transgenic animal models of the amyloid pathology continue to be valuable tools to examine molecular changes preceding the deposition of amyloid plaques and associated pathology (i.e. late inflammation, neuritic dystrophy, etc.).
While a post-doctoral fellow at the University of Cincinnati College of Medicine, he succeeded in establishing a variety of useful transgenic animal models to elucidate mechanisms of cardiac excitation - contraction coupling and heart failure.
Scientific meeting «Gene targeting, genome editing & transgenesis: research application» We are organizing joint meeting with our colleagues from Masaryk University in Brno dedicated to current progress in transgenic technologies in research application, animal models of diseases and Wnt signalling.
Moreover, knock in animal models for syngeneic studies and allowing us to isolate transgenic armed effector cells are developed in order to show proof of concept for the diverse applicability of our modular targeting systems including for tumor diseases, autoimmune diseases, GvHD, transplantation / rejection as well as viral infections.