Sentences with phrase «of tuft cells»

The authors speculate that treatment of the mice with broad - spectrum antibiotics would kill multiple pathogens in the gut and alter the biome so that the proliferation of the tuft cells would be prevented.

«We were surprised to see that expression of the gene TSLP — which encodes a cytokine long known to be involved in epithelial - induced inflammation — was exclusive to a particular subset of tuft cells,» Haber noted.

The new study indicates that such infections in the mice cause the number of tuft cells to increase by five - to tenfold, leading the norovirus to replicate more efficiently.

Treating the mice with a powerful broad - spectrum antibiotic cocktail decreased the number of tuft cells and the risk of norovirus infection.

It thus finally became possible for the scientists to observe and measure the activity of the tufted cells under the microscope.

Not exact matches

In mice, norovirus infects rare cells in the lining of the gut called tuft cells.

Now, researchers at Washington University School of Medicine in St. Louis have shown, in mice, that the virus infects a rare type of intestinal cell called a tuft cell, so named because each cell sports a cluster of hairlike extensions on its surface.

Tropism for tuft cells determines immune promotion of norovirus pathogenesis.

If norovirus also targets tuft cells in humans, «maybe that's the cell type we need to be treating,» says study coauthor Craig Wilen, a physician scientist at the Washington University School of Medicine in St. Louis.

Identifying a role for tuft cells in the interactions between the virus and its host «is a significant step forward,» says immunologist David Artis of Weill Cornell Medicine in New York City, who was not involved in the study.

When grafted onto bald mice, the cells produced not only furry tufts but stretches of skin complete with the oil - producing glands that help keep it supple as well.

It involves a type of inhibitory neuron called short - axon (SA) cells, and a type of local excitatory neuron called external tufted (ET) cells.

Until the present study, demographic inference was based on only three Aboriginal Australian genomes; one was derived from a tuft of hair (taken from a deceased individual), and the other two from cell lines whose provenance is somewhat hazy.

For instance, the team uncovered a new type of chemical - sensing tuft cell (which helps alert the immune system to infection or other forms of injury) that displayed markers previously thought to be exclusive to immune cells and which may help sound the alarm about allergens and invading parasites.

And since the gut microbiome plays a role in regulating tuft cells, this a rare case of antibiotics being able to impact a viral disease.

Ordinarily, Coffin specializes in fish hearing — studying the hair - like tufts of sensory cells arrayed along each side of zebrafish in what is called the lateral line.

Key to each of these units is a structure known the «glomerulus», in which podocyte cells wrap themselves tightly around a tuft of capillaries separated only by a thin membrane composed of extracellular matrix, and leave slits between them to build an actual filtration barrier.