In one study (1), prostate cancer patients who added about 3 heaping tablespoons of ground flaxseed daily to their diet, had more slowly - dividing tumor cells and a greater rate
of tumor cell death than men who did not follow such a diet, after about 5 weeks.
Along with the study's co-first authors, Drs. Aayoung Hong and Gatien Moriceau, Lo hypothesized that if they could identify the key tumor cell processes triggered by withdrawal of MAPK inhibitors, then scientists can exploit these process with existing or investigational drugs to trigger the maximal levels
of tumor cell death immediately following cessation of the initial therapy.
Not exact matches
Mogroside V has been found in research to have the ability to inhibit
tumor growth in pancreatic cancer by interfering with the rapid dividing
of cancer
cells, preventing angiogenesis (blood flow to the
tumor), and even promoting cancer
cell death (10).
The introduction
of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response
of the infant immune system to pathogens.47 - 51 A greater amount
of natural - killer
cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach
of breastfed children is better for the promotion
of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike
death in
tumor cells.51, 53
For some years now, a new class
of drugs called antibody - drug conjugates (ADCs) have been used, which work in two ways: they consist
of an antibody that binds selectively to the
tumor cell receptor and interrupts the signal to propagate; they also act as a transport vehicle for a chemical substance that enters the cancer
cells with the antibody and triggers their
death.
Lo's team set out to find ways to further weaken the
tumors, since the drug addiction response (which can range from a mere slow down
of the cancer's growth rate to cancer
cell death), can be used to improve clinical outcomes.
Giving the mice antibiotics helped gemcitabine kill
tumor cells, increasing the number
of tumor cells going through a type
of cell death called apoptosis from about 15 percent to 60 percent or more.
However, some 80 percent
of solid
tumors churn out extra thymidine kinase, which is thought to prevent cancer
cell death.
The primary cause
of death from breast cancer is the spread
of tumor cells from the breast to other organs in the body.
The researchers identified a genetic mutation in the
tumor cells that plays a role in both the growth and the
death of a
cell.
The researchers conducted genetic tests and found that many
of the
tumor cells had a mutation in a gene called PPM1D, which causes
cells to proliferate and avoid natural
death.
Glioblastoma is the most lethal form
of primary brain
tumor and leads to
death in patients by invading the brain tissue in a process that allows single
cells to move through normal brain tissue, which makes complete surgical removal
of the
tumor impossible.
New research shows that microRNA - 486 is a potent
tumor - suppressor molecule in lung cancer, and that the it helps regulate the proliferation and migration
of lung - cancer
cells, and the induction
of programmed
cell death, or apoptosis, in those
cells.
This is important to avoid missegregation
of the genetic material, which may result in
cell death or
tumor formation.
Arising from the Schwann
cells of the vestibular (balance) nerve, these
tumors can grow to the point
of damaging nearby structures — and can lead to
death by compressing the brainstem.
A new study led by University
of Kentucky researchers suggests that activating the
tumor suppressor p53 in normal
cells causes them to secrete Par - 4, another potent
tumor suppressor protein that induces
cell death in cancer
cells.
The researchers also note that more investigation is needed to fully understand all the mechanisms by which HOXC10 mediates
cell proliferation and
death, and the roles it may play in different types
of tumors.
A section
of a
tumor organoid grown from
cells derived from a patient with high - grade serous ovarian cancer (left) and a mini-
tumor treated with ReACp53, resulting in extensive cancer
cell death.
Adds Liu: «With metastatic cancers accounting for around 90 %
of deaths from solid
tumors, the hope is that one day a device that can enable the analysis
of single
tumor cells circulating in the blood could make a big difference in early diagnosis, detection and monitoring
of numerous types
of cancer, without invasive biopsies.»
Genomic data from the HeLa
cell line are also being released with the final version
of the paper as a result
of discussions between leaders
of the National Institutes
of Health (NIH) and relatives
of Henrietta Lacks, from whose cervical
tumor the original HeLa
cell line was derived prior to her
death in 1951.
«But the antioxidant boosted the ability
of the
tumor cells to metastasize, an even more serious problem because metastasis is the cause
of death in the case
of melanoma.
Recently, many scientists came to suspect that a protein called NF - κB, a master regulator
of infection and inflammation, was at work; in 1996, several groups had found that it also inhibited
cell death, which can lead to
tumor formation.To find out whether suspicions about NF - κB were well - founded, molecular biologist Michael Karin
of the University
of California, San Diego, and his colleagues turned to a mouse model
of colitis.
When using a well established model
of colorectal cancer, the researchers observed that dietary emulsifier consumption was sufficient to make the animals more susceptible to developing colonic
tumors because this created and maintained a pro-inflammatory environment associated with an altered proliferation / apoptosis (
cell death) balance.
Dr. Shawn Li, PhD, and his team at Western's Schulich School
of Medicine & Dentistry, identified that a protein called Numb functions to promote the
death of cancer
cells by binding to and stabilizing a
tumor suppressor protein called p53 - a master regulator
of cell death.
Considerable previous research in
cell cultures has demonstrated that low doses
of ionizing radiation results in «bystander» effects, in which nearby, unexposed tissues suffer
cell death, mutations, and
tumor - inducing growth (ScienceNOW, 7 September 2005).
In the sensitive
tumor models, the ability
of anti — cytotoxic T lymphocyte — associated protein 4 or anti — programmed
cell death 1 therapy to increase vessel perfusion strongly correlated with its antitumor efficacy.
In a collaborative study, researchers from Chinese Academy
of Medical Sciences and Peking Union Medical College, BGI, Shantou University Medical College and other institutions identified important alterations
of tumor - associated genes and tumorigenic pathways in esophageal squamous
cell cancer (ESCC), one
of the leading cause
of cancer
death worldwide.
As an initial focus, researchers at Chicago will search for novel ways to take advantage
of steroid hormones and their receptors to detect metastases, define their boundaries and deliver treatments directly to
tumor cells in order to inhibit
cell division or promote
cell death.
More importantly, Zhang and his team for the first time found that treating the pancreatic
tumor cells with MIR506 induced autophagy, a process that occurs as a normal and controlled part
of an organism's growth or development and that could promote cancer
cell death.
Researchers at the University
of Chicago noted that in recent years, genetically engineered herpes simplex virus studied for its efficacy against malignant
tumors of the central nervous system and the liver was blocking certain types
of cell death and proliferation
of surviving
cells.
Tumor sizes decreased in the treated mice, areas
of cell death were visible, and all AAV2 treated mice survived through the study, a direct contrast to the untreated mice.
Although persistent loss
of IGF - 1R expression ultimately induced
cell stasis and
death, both
of these processes are regulated by the
tumor suppressor gene p53 that is commonly mutated in human prostate cancers.
Finally, loss
of FANCD2 in BRCA1 / 2 - deficient
tumors enhances
cell death.
Tumor cell programmed death ligand 1 - mediated T Cell suppression is overcome by coexpression of C
cell programmed
death ligand 1 - mediated T
Cell suppression is overcome by coexpression of C
Cell suppression is overcome by coexpression
of CD80.
Stimulation
of TRAIL protein is sustained in both
tumor and normal
cells, with the normal
cells contributing to the TIC10 - induced cancer
cell death through a bystander effect.
Downregulation
of tumor suppressors and upregulation
of proto - oncogenes can directly inhibit the ability
of a
cell to undergo programmed
cell death while simultaneously stimulating growth and division.
Stimulation
of the STING pathway appears essential to generate a de novo immune response comprising
tumor cell death, generation
of antigens, and activation
of the innate and adaptive immune system.
If he can determine how to speed up engulfment
of dead
tumor cells from brain tissue, it is his hope to reduce the harmful inflammation that causes
death of surrounding neurons.
The King Lab has pioneered the use
of selectin proteins to deliver apoptosis
death signals to
tumor cells in flowing blood, and to deliver therapeutic cargo (e.g., siRNA, chemotherapeutics) encapsulated in nanoscale liposomes.
Likewise, unregulated growth, abnormal
cell division, and defective
cell death pathways are hallmark features
of tumors.
New data and research approaches have created opportunities for researchers to study in detail many aspects
of cancer biology, including how the normal biological programs
of cell proliferation and
death are altered during cancer and how the immune system responds to
tumors.
Further studies showed that Notch1 knockdown in NSCLC helps induce
cell death (which inhibits
tumor initiation and growth); this process is mediated by p53, and thus the effects
of inhibiting Notch1 require functional p53.
Swanton's new lab set out to identify specific genes that, when inhibited, result in the
death of tumor cells that displayed aneuploidy, meaning they had more or less than the normal set
of 46 chromosomes.
Dr. Altieri also leads a research program that studies how
tumor cells evade programmed
cell death and the role
of mitochondria, power plant
of the
cells, in
tumor metabolism.
The observed effect, an influx
of T
cells to the
tumor, is distinct from the programmed
cell death produced by the checkpoint inhibitors.
The most famous, oldest, and most commonly used immortal
cell line, dubbed HeLa, originated in a
tumor sample taken from an African - American woman, Henrietta Lacks, who is the subject
of the recent book The Immortal Life
of Henrietta Lacks.9 The
tumor cells, harvested at Johns Hopkins Hospital, gave rise to the eponymous HeLa
cell line which researchers have used continuously since her
death in 1951 for numerous experiments, including Jonas Salk's development
of the polio vaccine.
Pterostilbene, found exclusively in blueberries, has been shown in studies to induce apoptosis — programmed
cell death —
of malignant
cells, and to act against
tumors.
It promotes
tumor cell proliferation and resistance to apoptosis (programmed
cell death after a certain number
of cell divisions, a good thing when it comes to cancer
cells).
In a laboratory study published in 2012 in Oncology Reports, chokeberries caused the
death of malignant brain
tumor cells.
And, though they were skeptical that they would observe any difference in
tumor biology in the diet - treated patients with such a short - term dietary intervention, just within those few weeks, they found significantly lower cancer proliferation rates, and significantly higher rates
of cancer
cell death.