Sentences with phrase «of tumor cell populations»

The technology successfully tracked in real - time how the diversity of tumor cell populations were changing in response to particular therapies for all of the patients studied, and was highly predictive of treatment effectiveness and patient outcomes.

Not exact matches

The population of tumor cells was SELECTED to be resistant to the drug!

Small populations of adult stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out cells and tissues, and evidence is growing that rare cancer stem cells are responsible for the uncontrolled growth of some malignant tumors, including glioblastoma.

Previous studies have examined cancer stem cells (CSCs)-- small populations of cells within a tumor that are resistant to chemotherapy.

«What our findings show is that the problems with iPS cells don't just involve one or two or a few abnormal iPS cells escaping into the body and forming tumors, but that the whole population of cells is screwed up,» Lanza says.

In the last few years, a bulk of data pointing to a small population of cells in tumors that maintain tumor growth, are particularly resistant to chemotherapy, are responsible for relapses, and develop metastases.

Within a single tumor exists such an astonishingly varied population of cells, each with its own combination of normal and abnormal genes, that at least some cells nearly always have a way to survive any particular attack.

According to Semenza, «Chemotherapy may kill more than 99 percent of the cancer cells in a tumor but fail to kill a small population of cancer stem cells that are responsible for subsequent cancer relapse and metastasis.»

Nearly all of the cancer cells died as a result, but a residual population of tumor cells survived and became dormant.

In this mouse model, mutations in Kras and p53 genes resulted in the formation of individual tumor cell populations that were labeled with different colors.

«The recent discovery of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival of disseminated tumor cells could explain cancer cells that relapse early, but in late relapsing populations, what tumor cells do from the time of dissemination to the time they become clinically detectable has been a big question.»

The study, which appears August 3 in the peer - reviewed journal Nature Communications, showed that pairing the chemotherapy with an experimental drug eliminates the deadly population of cells believed to be responsible for repopulating the tumor.

Tumors, for example, are known to contain different populations of cells, some of which are quite different to each other in their genetic makeup.

Most of the cells that made up the tumors were positive for CA125, but the researchers found a small population that were negative and focused on those, Janzen said.

That is, they contained multiple populations of cells, including the so - called JARID1B cells, which their research suggested was responsible for allowing tumors to survive drug therapy.

A single tumor is composed of many different populations of cells.

Their recent study, which appears as the cover article in the May issue of Cancer Research, shows that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment.

They have detected, for example, revved up signaling molecules involved in inflammation, such as tumor necrosis factor α (TNFα) and other cytokines; skewed populations of natural killer cells and other immune cells; imbalances in the protein - destroying enzymes called proteases; and a shortening of the telomeres, the «end caps» on chromosomes, which indicates prematurely aged cells.

The classical concepts of angiogenesis consider the endothelial cells within tumors as a rather passive cell population that merely reacts in response to growth factors released by the tumor cells.

He said that genetic and morphological heterogeneity within populations of animal cells is an emerging phenomenon and has been observed in tumor populations.

Antibodies stimulate the recruitment of additional immune cells that help to activate T cells; the vaccine stimulates proliferation of T cells that can attack the tumor; IL - 2 helps the T cell population to expand quickly; and the anti-PD1 molecule helps T cells stay active longer.

The second branch of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily target the tumor cells, but to act on the recruitment of yet another tumor - promoting cell population from the bone marrow.

Even in the early stages of tumor growth, the microRNA remains active to keep the cancer stem cell population down.

The results of our limiting dilution analysis confirmed that the isolated CSCs (CD24 − / CD44 + / ESA +) population has significantly stronger ability of generating tumors compared with non-stem cell population (Table 1).

Cancer stem - like cells (CSC) are a minor population of tumor mass and considered to have abilities of tumor initiation, differentiation, and chemoresistance (1).

Having a pure population of cardiac muscle cells is essential for avoiding tumor formation after transplantation, but has been technically challenging.

Together, these results suggested that EMT contributes to the establishment of a small cell subpopulation in malignant tumors; this population is then capable of driving the regeneration of the tumor, even when the bulk tumor cell mass is destroyed by therapeutic regimens.

«Not only do you have more of the traditional stem cells (on a high - fat diet), but now you have non-stem-cell populations that have the ability to acquire mutations that give rise to tumors.»

A major new insight is the realization that different tumors of the same type may rely on entirely different tumor stem cell populations.

Known as tumor - initiating cells with stem like properties these cells have many characteristics in common with normal stem cells in that they are self - replicating and capable of giving rise to populations of differentiated cells.

However, as demonstrated by a recent report from Stuelten and colleagues [13], the complexity of CSC markers continues to pose challenges for identifying and isolating the putative tumor stem cell populations by the cell - sorting approach.

It has been postulated that hypoxia contributes directly to the development of more aggressive cancers by exerting selective pressure on the tumor cell population to favor cells that can survive decreased O2 and nutrients [18 — 20].

Excitingly, a single dose of any of the three NK cell populations assessed led to a significant reduction in tumor burden, although the iPSC ‐ derived NK group demonstrating a trend toward overall better activity.

The laboratory currently pursues four integrated research objectives: 1) Defining how dynamic regulation of adhesion and migration controls metastasis, 2) Identification and characterization of the metastatic cell populations within a primary tumor, 3) Experimental modeling of metastasis in a clinically relevant manner, and 4) clinical implementation of molecular markers of migration as biomarkers of tumor progression and metastasis.

This approach involves first generating many monoclonal antibodies raised against «crude» tumor cell antigen populations — whole cells and cell membranes — and then screening for those that block the metastatic ability of the cell.

I am developing mathematical and statistical tools to disentangle tumor cell population structure, enabling an earlier and more accurate diagnosis of the disease and better - informed clinical decisions.

Here, we elaborate on how these findings pertain to cancer cells dispersed in the tumor - adjacent stroma of breast cancer tissues, and how BH3 - mimetics may provide a therapeutic strategy to eliminate cancer cell populations that have passed through an EMT.

A unique focus of my work is on the impact of heterogeneity within tumors and tumor cell populations, including subpopulations commonly referred to as «cancer stem cells», on the immune response.

Because of small sample size, the changes in tumor - initiating cell number were not significant (P > 0.05), but these data are supportive of the in vitro findings and suggest that hypoxia may have a positive effect on the tumor - initiating cell population in ER - α — positive breast cancers and a negative effect in ER - α — negative tumors.

No significant differences were seen between the normoxic and hypoxic anoikis - resistant populations collected from MCF7 cells and a single significant gene change (PIP) was seen in T47D (Table 1) suggesting that the CSC - enriched population remains virtually unchanged following hypoxic culture and the increase in MFC, HFC, and tumor initiating cells is, therefore, due to expansion of the population, perhaps by increased symmetric self - renewal of the CSC or de-differentiation of early progenitor cells, rather than simply the acquisition of anoikis resistance in non-CSC.

CSC enrichment was achieved by collection of anoikis - resistant cells as we have previously shown this population to be highly enriched for mammosphere and tumor - initiating cells (25).

This confirmed that the gene regulatory switch is highly specific to one cell type, monocytes and that tumor cell invasion in the absence of this population had nothing to do with deregulated macrophage activity.

Through image analysis of breast tumors and TDLNs, we have found that immune cell populations as well as their spatial distributions and clustering patterns have strong correlation with clinical outcome.

In 2016, Dmitry I. Gabrilovich, M.D., Ph.D., program leader of Wistar's Translational Tumor Immunology program, and his research team identified a marker for myeloid - derived suppressor cells (MDSCs), a population of immune cells implicated in tumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunotheTumor Immunology program, and his research team identified a marker for myeloid - derived suppressor cells (MDSCs), a population of immune cells implicated in tumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunothetumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunotherapy.

The tumor microenvironment is comprised of heterogeneous populations of cells including cancer, immune and tumor associated stromal cells.

Haihui Lu, Ph.D., a CRI fellow at the Whitehead Institute for Biomedical Research, has identified a surface marker that distinguishes a population of breast cancer cells that are more prone to metastasis and demonstrate higher levels of «stemness,» the ability to seed other tumors.

Title: Infiltrating immune cells in breast cancer subtypes Date / Time: Tuesday, April 17 2018, 8:00 am - 12:00 pm CT Author: J.L. Matta et al, Ponce Health Sciences Institute and H. Lee Moffitt Cancer Center Poster # / Location: 5698 / Section 32, Board 4 Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7977 Demonstrates the value of combining PAM50 subtype distribution with tumor immune profiling to identify biologically distinct patient populations; the combination of these signatures could be applied to the development of specific immunotherapeutics.

Considering that miR - 142 is highly expressed in human BCSCs, but weakly expressed or undetectable in the stem / progenitor population of the mammary epithelial cells, our result suggest that the upregulation of miR - 142 and its enhancement of the miR - 150 expression seem to be especially relevant in the breast tumor progression in vivo.

He goes on to say, «One theory is that when patients ingest our Turkey Tail mycelium, the immune system's increased populations of NK cells and their associated CD8 glycoproteins are better able to discover and bind to receptor sites on the stroma of tumors, thus allowing NK invasion.

Mast cells can be found in all tissues of the body but typically form tumors on the skin in close to 20 percent in the canine population.