Sentences with phrase «of tumor characteristics»
Storm, who performs surgery on children with brain tumors, added that, «Better understanding of tumor characteristics, as we found in this research, will help guide our surgical planning and clinical decisions for patients with PLGGs in this current era of target - centric clinical trials and personalized medicine.»
https://www.sciencedaily.com/ Not exact matches
«We now hope to move on to investigate how these bacteria contribute to the development of the characteristic stomach tumor types that are associated with each of these conditions.»
«This finding,» Villanueva said «opens the door to developing new biomarkers and new therapeutic strategies exploiting these characteristics of exosomes in breast tumors, and other tumors such as ovarian and endometrial cancer among others.»
The three study groups had a similar distribution of baseline characteristics, with the exception of tumor size.
Working with colleagues at St. Vincent's Hospital in Sydney, Martin identified two individuals who had the characteristics of hereditary nonpolyposis colorectal cancer, which is usually caused by a mutation that inactivates one of a person's two copies of the tumor suppressor gene MLH1, but who showed no signs of mutation.
«If we can identify the point at which tumor cells acquire the characteristics of stem cells, it will be possible to look for ways to interrupt the process and avoid progression of the disease.»
While previous studies have surveyed the genomic characteristics of tumors confined to the prostate gland, the new study is the first to focus on metastatic hormone resistant prostate cancers, which can be difficult to treat because they often develop resistance to standard treatments.
Their study showed that the protein neuropilin - 1 (Nrp1) is crucial for the localization of TAMs inside hypoxic tumor regions, which strengthens the pro-tumoral characteristics of TAMs.
The cells in such a brain tumor can display very different characteristics, such as varying cell size or number of cell nuclei.
Brain tumors arise in the glia, or supportive cells, of the brain and now are classified by their histology — characteristics visible via microscopy — and their cell of origin, either astrocytes or oligodendrocytes.
With the help of various mouse models for pancreatic cancer, they have succeeded in elucidating the molecular pathways of tumor development in detail and have gained a better understanding of how various characteristics of the disease arise.
Which pathway the cell follows, and which genes are involved then largely determine the characteristics of a pancreatic tumor.
«We found that many more mice developed tumors when given the cells that we had engineered to have these stem cell characteristics, and they had a much higher incidence of metastasis in the lungs,» Kilian said.
This led to development of newer technology, called single cell sequencing (SCS), that has had a major impact in many areas of biology, including cancer research, neurobiology, microbiology, and immunology, and has greatly improved understanding of certain tumor characteristics in cancer.
Columbia University Irving Medical Center (CUIMC) and NewYork - Presbyterian researchers have created patient - specific bladder cancer organoids that mimic many of the characteristics of actual tumors.
This is the first study to suggest that it might be possible to personalize recommended diets for breast cancer survivors based on the molecular characteristics of their primary tumor.
In this proof - of - principle study, the researchers showed, using DNA sequencing and karyotyping technologies, that the patient's unique cell characteristics were maintained in both normal and tumor CR laboratory cells.
In their paper published online in the Journal of Clinical Oncology, the researchers report that several genetic characteristics of more aggressive tumors were significantly more prevalent in African American patients and appeared to be associated with a greater risk of tumor recurrence.
The registries collect information about patient and tumor characteristics and first course of cancer - directed treatment.)
To search for other characteristics of ccRCC tumors that influences immunotherapy response or resistance, the researchers used whole - exome DNA sequencing to analyze tumor samples from 35 patients treated in a clinical trial with the checkpoint blocker nivolumab (Opdivo).
These studies revealed that the void's physical characteristics — the type and location of missing bone — were consistent with a fibrous dysplastic neoplasm, a tumor caused by a bone growth disorder, the scientists report online today in PLOS ONE.
To avoid being targeted by their hosts» immune systems, tumors maintain an immunosuppressive environment by manipulating the characteristics of the immune and vascular system.
However, when we controlled for tumor characteristics and types of breast surgery, there was still a significant difference,» says Black.
This indicated that the cell of origin also has a direct influence on the characteristics of human tumors,» says Uhrbom.
«We discovered that several important characteristics of the cancer cells could be linked to the tumor's cell of origin.
«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.
Different cell types exhibit characteristic patterns of DNA methylation which enable scientists to draw conclusions about a tumor's cellular origin.
It is presently possible to differentiate about 100 types of CNS tumors based on tissue characteristics.
To be able to treat cancer of the central nervous system (CNS) successfully, it is important to have very precise knowledge about the molecular characteristics of the tumors in order to «give them the right name.»
Lloyd A. Greene and Arthur S. Tischler of the Harvard Medical School demonstrated in 1977 that cells of the line designated PC12 (which are derived from a rat tumor) respond to NGF by acquiring properties characteristic of sympathetic neurons.
Douglas Hanahan and Robert Weinberg publish an update of their seminal review, Hallmarks of Cancer, adding to the list of cancer characteristics the ability of tumors to evade the immune system and emphasizing immune system - induced inflammation as an enabling characteristic in cancer development.
About 1,000 patients whose tumor characteristics most closely match one of the 20 or so gene - targeting drugs offered in the study will be put into groups of about 30 patients to get that drug.
Bethesda, Md., Wed., May 1, 2013 - A comprehensive genomic analysis of nearly 400 endometrial tumors suggests that certain molecular characteristics - such as the frequency of mutations - could complement current pathology methods and help distinguish between principal types of endometrial tumors, as well as provide insights into potential treatment strategies.
We expect that the CRI iAtlas will help to accelerate discovery and improve patient outcomes by providing researchers greater access to genomics data to better understand the immunological characteristics of the tumor microenvironment and its potential impact on patient responses to immunotherapy,» said Jill O'Donnell - Tormey, Ph.D., CEO and director of scientific affairs at CRI.
But tumors, across the myriad permutations of the disease, share one characteristic: unpredictability.
Here, we describe the genotypic and phenotypic characteristics of HR - deficient EOCs, discuss current and emerging approaches for targeting these tumors, and present challenges associated with these approaches, focusing on development and overcoming resistance.
Researchers at the Mayo Clinic are taking a similar approach, using PDX mice to match genetic characteristics of an individual's tumor to specific drugs.
The researchers looked at several factors that might explain this racial difference, such as whether there were differences in tumor characteristics between black patients and white patients, or differences in a family history of breast cancer — both factors that a doctor must consider before deciding whether a genetic test will likely benefit a particular patient.
Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.
«But we know that tumors generally develop from a single cell or a small number of cells of a specific cell type, which is one of the major determinants of the characteristics of tumor cells,» explains postdoctoral researcher and co-author Dinorah Friedmann - Morvinski.
Known as tumor - initiating cells with stem like properties these cells have many characteristics in common with normal stem cells in that they are self - replicating and capable of giving rise to populations of differentiated cells.
«They displayed all the characteristics of cancer stem cells, and less than 100 and as few as 10 cells were enough to initiate a tumor when injected into immunodeficient mice,» says Friedmann - Morvinski.
«Cells expressing each of these characteristics were identified across all tumors, suggesting cells sensitive or resistant to chemotherapy are both presents in the same tumor,» confirmed Stewart.
The median time to response was 1.8 months, and responses occurred regardless of tumor type, patient age, or specific TRK fusion characteristics.
Our underlying premise is that the tumor microenvironment is immune suppressive because cancer cells elicit responses characteristic of wound healing and tissue regeneration.
select the most effective therapy based on the unique biologic characteristics of the patient and the molecular properties of a tumor or other disease
For example, the goal of the drug response challenge is to predict how a tumor will respond to a drug based on the characteristics of both the tumor and the drug, the information for which is identified through previously available data, such as tumor samples and previous drug screens.
But every patient's tumor is different, and clinical trials group all patients together to test a novel therapy — irrespective of the unique characteristics of that patient's tumor, he says.
Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??
CRI postdoctoral fellow Dr. Haihui Lu at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, is studying some of the unique characteristics that differentiate metastatic cancer cells from primary tumor cells, and specifically aims to understand how these unique characteristics enable breast cancer cells to escape elimination by the immune system.