Sentences with phrase «of tumor destruction»

M032 kills tumor cells directly through oncolytic replication and then proceeds to infect tumor cells in proximity, continuing the process of tumor destruction.

Not exact matches

The key to this approach is minimizing healthy tissue damage while maximizing cancerous tumor destruction of the sort that improves recognition of the tumor by the immune system.

It can be used in computer simulations to optimize the destruction of tumors in radiotherapy while sparing healthy tissue,» highlights Professor Matthias Kling of the impact of the work.

The selective pressure of the competent immune system «edits» the tumor by selecting for cells that can avoid immune destruction.

Blood clots lead to both destruction of the healthy and tumor tissue and hypoxia, a shortage of oxygen that drives more aggressiveness in the tumor.

Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer.

Interestingly, when parental d42m1 sarcoma cells were transplanted into wild - type mice, around 20 % of recipients developed «escape» tumors which evaded immune destruction and progressed (escape clones).

They are important especially for the destruction of cells infected by a virus or of tumor cells.

Central to the concept of immunoediting is the idea that T - cell recognition of tumor - specific antigens drives the destruction of early tumors, and later the antigenic «sculpting» of persistent tumor cells.

In other words, T - cell destruction of cells bearing mutant spectrin - B2 «sculpted» the tumor cells into poorly immunogenic cells lacking the antigen, which progressed and grew out.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

Tumors» mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.

They found that destruction of the cancer was mediated by killer T cells residing in the tumor rather than newly infiltrating killer T cells.

A primary function of CTLs is the selective recognition and destruction of tumor cells.

Experiments in mice lacking CTLA - 4 and use of CTLA - 4 antibodies demonstrated that absence of CTLA - 4 or blocking its activity could lead to T cell activation and tumor destruction.

Duntas (2015) articulates, «In susceptible individuals, iodine excess increases intra-thyroid infiltrating Th17 cells and inhibits T regulatory (Treg) cells development, while it triggers an abnormal expression of tumor necrosis factor - related apoptosis - inducing ligand (TRAIL) in thyrocytes, thus inducing apoptosis and parenchymal destruction» (31, p. 721).

GcMAF activity is essential to a healthy immune system and can also assist in the destruction of tumors entirely.

When they do, the symptoms that we see are due to the physical destruction of these organs as the tumor grows and crowds out healthy cells.

I - 131 is only absorbed by tissue producing thyroid hormone; the radiation is then given off by the isotope, resulting in destruction of the tumor.

But a recent discovery in the world of holistic medicine has shown very promising results in the reduction and destruction of such tumors...

In dogs, the most common cause of secondary hypothyroidism is destruction of pituitary thyrotrophs by an expanding, space - occupying tumor.

There are a variety of medications that can help brain tumor patients using targeted destruction of presence of the tumor, such as motor skills, speech, muscle strength and cognitive processes.